SCHOOL OF PHARMACY
VIRGINIA COMMONWEALTH UNIVERSITY
ADVANCED MEDICINAL CHEMISTRY MEDC 604
Examination (Dr. Desai) March 2, 2002
Name _______________________________ Pledge ____________________________
This part consists of 3 questions (11 points).
1. Heparin (4 points)
A: enhances the reaction of thrombin with factor Xa
B: enhances the reaction of thrombin with antithrombin
C: reduces the reaction of thrombin with factor Xa
D: reduces the reaction of thrombin with antithrombin
2. Coumarins and 1,3-indanediones: (4 points)
A: prevent the aggregation of platelets
B: prevent the formation of fibrin
C: enhance the aggregation of platelets
D: enhance the formation of fibrin
3. Arrange the following anti-anginal molecules in the order of their increasing duration of
action. Use 1 for shortest duration, 2 for next best and 3 for longest duration. (3 points)
ONO2
ONO2
O2NO
O2NO
ONO2
O2NO
ONO2ONO
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