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Safety Data Sheet
acc. to OSHA HCS
Printing date 04/27/2022 Revision date 04/27/
1 Identification
· Product identifier
· Trade name: Acetic Anhydride
· Article number: 400031 · CAS Number: 108-24- · EC number: 203-564- · (^) Index number: 607-008-00- · Application of the substance / the mixture This product is for research use - Not for human or veterinary diagnostic or therapeutic use.
· Details of the supplier of the safety data sheet · (^) Manufacturer/Supplier: Cayman Chemical Co. 1180 E. Ellsworth Rd. Ann Arbor, MI 48108 USA
· Information department: Product safety department · Emergency telephone number: During normal opening times: +1 (734) 971- US/CANADA: 800-424- Outside US/CANADA: 703-741-
2 Hazard(s) identification
· Classification of the substance or mixture
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GHS02 Flame
Flam. Liq. 3 H226 Flammable liquid and vapor.
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GHS05 Corrosion
Skin Corr. 1B H314 Causes severe skin burns and eye damage.
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GHS
(Contd. on page 2) US
Safety Data Sheet
acc. to OSHA HCS
Printing date 04/27/2022 Revision date 04/27/
Trade name: Acetic Anhydride
(Contd. from page 1) Acute Tox. 4 H302 Harmful if swallowed. Acute Tox. 4 H332 Harmful if inhaled.
· Label elements · (^) GHS label elements The substance is classified and labeled according to the Globally Harmonized System (GHS). · Hazard pictograms
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GHS
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GHS
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GHS
· Signal word Danger
· Hazard-determining components of labeling: Acetic anhydride · (^) Hazard statements H226 Flammable liquid and vapor. H302+H332 Harmful if swallowed or if inhaled. H314 Causes severe skin burns and eye damage. · Precautionary statements P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233 Keep container tightly closed. P240 Ground/bond container and receiving equipment. P241 Use explosion-proof electrical/ventilating/lighting/equipment. P242 Use only non-sparking tools. P243 Take precautionary measures against static discharge. P260 Do not breathe dusts or mists. P264 Wash thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P301+P312 If swallowed: Call a poison center/doctor if you feel unwell. P301+P330+P331 If swallowed: Rinse mouth. Do NOT induce vomiting. P303+P361+P353 If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a poison center/doctor. P321 Specific treatment (see on this label). P363 Wash contaminated clothing before reuse. P370+P378 In case of fire: Use CO2, powder or water spray to extinguish. P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · (^) Classification system: · NFPA ratings (scale 0 - 4)
3
2 0
Health = 3 Fire = 2 Reactivity = 0
(Contd. on page 3) US
Safety Data Sheet
acc. to OSHA HCS
Printing date 04/27/2022 Revision date 04/27/
Trade name: Acetic Anhydride
(Contd. from page 3) · Advice for firefighters · (^) Protective equipment: Mouth respiratory protective device.
6 Accidental release measures
· Personal precautions, protective equipment and emergency procedures Mount respiratory protective device. Wear protective equipment. Keep unprotected persons away. · Environmental precautions: Do not allow to enter sewers/ surface or ground water. · Methods and material for containment and cleaning up: Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust). Use neutralizing agent. Dispose contaminated material as waste according to item 13. Ensure adequate ventilation. · Reference to other sections See Section 7 for information on safe handling. See Section 8 for information on personal protection equipment. See Section 13 for disposal information. · (^) Protective Action Criteria for Chemicals · PAC-1: 0.5 ppm
· PAC-2: 15 ppm · (^) PAC-3: 100 ppm
7 Handling and storage
· Handling: · (^) Precautions for safe handling Ensure good ventilation/exhaustion at the workplace. Prevent formation of aerosols. · Information about protection against explosions and fires: Keep ignition sources away - Do not smoke. Protect against electrostatic charges. Keep respiratory protective device available.
· Conditions for safe storage, including any incompatibilities · Storage: Store in accordance with information listed on the product insert. · Requirements to be met by storerooms and receptacles: (^) No special requirements. · Information about storage in one common storage facility: Not required. · Further information about storage conditions: (^) Keep receptacle tightly sealed. · Specific end use(s) No further relevant information available.
8 Exposure controls/personal protection
· (^) Additional information about design of technical systems: No further data; see item 7. (Contd. on page 5) US
Safety Data Sheet
acc. to OSHA HCS
Printing date 04/27/2022 Revision date 04/27/
Trade name: Acetic Anhydride
(Contd. from page 4) · (^) Control parameters · (^) Components with limit values that require monitoring at the workplace: 108-24-7 Acetic anhydride PEL Long-term value: 20 mg/m³, 5 ppm REL Ceiling limit value: 20 mg/m³, 5 ppm TLV Short-term value: 3 ppm Long-term value: 1 ppm A · Additional information: The lists that were valid during the creation were used as basis.
· Exposure controls · Personal protective equipment: · General protective and hygienic measures: Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing. Wash hands before breaks and at the end of work. Avoid contact with the eyes and skin. · Breathing equipment: In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air. · (^) Protection of hands:
_S
Protective gloves
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation. Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/ the chemical mixture. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation · Material of gloves The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. · (^) Penetration time of glove material The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed. · Eye protection:
_R
Tightly sealed goggles
9 Physical and chemical properties
· Information on basic physical and chemical properties · General Information · Appearance: Form: Liquid Color: Colorless · (^) Odor: Pungent (Contd. on page 6) US
Safety Data Sheet
acc. to OSHA HCS
Printing date 04/27/2022 Revision date 04/27/
Trade name: Acetic Anhydride
(Contd. from page 6) · Hazardous decomposition products: No dangerous decomposition products known.
11 Toxicological information
· (^) Information on toxicological effects · Acute toxicity: · (^) LD/LC50 values that are relevant for classification: ATE (Acute Toxicity Estimate) Oral LD50 1,780 mg/kg (rat) Inhalative LC50/4 h 1,000 mg/l (rat)
108-24-7 Acetic anhydride Oral LD50 1,780 mg/kg (rat) Dermal LD50 4 mg/kg (rabbit) Inhalative LC50 1,000 mg/m³/4h (rat) LC50/4 h 1,000 mg/l (rat) Irritation of skin Irritation (rabbit) · (^) Primary irritant effect: · on the skin: Caustic effect on skin and mucous membranes. · (^) on the eye: Strong caustic effect. · Sensitization: No sensitizing effects known. · (^) Additional toxicological information: Swallowing will lead to a strong caustic effect on mouth and throat and to the danger of perforation of esophagus and stomach. · (^) Carcinogenic categories · IARC (International Agency for Research on Cancer) Substance is not listed.
· NTP (National Toxicology Program) Substance is not listed. · (^) OSHA-Ca (Occupational Safety & Health Administration) Substance is not listed.
12 Ecological information
· Toxicity · (^) Aquatic toxicity: No further relevant information available. · Persistence and degradability No further relevant information available. · (^) Behavior in environmental systems: · Bioaccumulative potential No further relevant information available. · (^) Mobility in soil No further relevant information available. · Additional ecological information: · (^) General notes: Water hazard class 1 (Assessment by list): slightly hazardous for water Do not allow undiluted product or large quantities of it to reach ground water, water course or sewage system. Must not reach bodies of water or drainage ditch undiluted or unneutralized. · Results of PBT and vPvB assessment · PBT: Not applicable. (Contd. on page 8) US
Safety Data Sheet
acc. to OSHA HCS
Printing date 04/27/2022 Revision date 04/27/
Trade name: Acetic Anhydride
(Contd. from page 7) · vPvB: Not applicable. · (^) Other adverse effects No further relevant information available.
13 Disposal considerations
· Waste treatment methods · (^) Recommendation: Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
· Uncleaned packagings: · Recommendation: (^) Disposal must be made according to official regulations.
14 Transport information
· UN-Number · (^) DOT, IMDG, IATA UN
· (^) UN proper shipping name · DOT, IATA Acetic anhydride · IMDG ACETIC ANHYDRIDE
· Transport hazard class(es)
· DOT
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· Class 8 Corrosive substances · (^) Label 8
· (^) IMDG, IATA
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· Class 8 Corrosive substances · (^) Label 8
· (^) Packing group · DOT, IMDG, IATA II
· Environmental hazards: Not applicable.
· Special precautions for user Warning: Corrosive substances · (^) Hazard identification number (Kemler code): 83 · EMS Number: 8- · (^) Segregation groups Acids · Stowage Category A · (^) Stowage Code SW2 Clear of living quarters. (Contd. on page 9) US
Safety Data Sheet
acc. to OSHA HCS
Printing date 04/27/2022 Revision date 04/27/
Trade name: Acetic Anhydride
(Contd. from page 9) · (^) Chemicals known to cause developmental toxicity: Substance is not listed.
· Carcinogenic categories · (^) EPA (Environmental Protection Agency) Substance is not listed. · TLV (Threshold Limit Value) Substance is not listed.
· NIOSH-Ca (National Institute for Occupational Safety and Health) Substance is not listed. · Chemical safety assessment: (^) A Chemical Safety Assessment has not been carried out.
16 Other information All chemicals may pose unknown hazards and should be used with caution. This SDS applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this SDS. Cayman Chemical Company assumes no responsibility for incidental or consequential damages, including lost profits, arising from the use of these data. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this SDS is based on technical data judged to be reliable, Cayman Chemical Company assumes no responsibility for the completeness or accuracy of the information contained herein. · (^) Department issuing SDS: Environment protection department. · Contact: - · (^) Date of preparation / last revision 04/27/2022 / - · Abbreviations and acronyms: IMDG: International Maritime Code for Dangerous Goods DOT: US Department of Transportation IATA: International Air Transport Association EINECS: European Inventory of Existing Commercial Chemical Substances CAS: Chemical Abstracts Service (division of the American Chemical Society) NFPA: National Fire Protection Association (USA) HMIS: Hazardous Materials Identification System (USA) VOC: Volatile Organic Compounds (USA, EU) LC50: Lethal concentration, 50 percent LD50: Lethal dose, 50 percent PBT: Persistent, Bioaccumulative and Toxic vPvB: very Persistent and very Bioaccumulative NIOSH: National Institute for Occupational Safety OSHA: Occupational Safety & Health TLV: Threshold Limit Value PEL: Permissible Exposure Limit REL: Recommended Exposure Limit Flam. Liq. 3: Flammable liquids – Category 3 Acute Tox. 4: Acute toxicity – Category 4 Skin Corr. 1B: Skin corrosion/irritation – Category 1B US
