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52 Solved Questions on Immunology Exam 3 PCB 3233, Exams for Immunology, Exams of Nursing

Concordia University System (CUS)Nursing

52 Solved Questions on Immunology Exam 3 PCB 3233, Exams for Immunology 52 Solved Questions on Immunology Exam 3 PCB 3233, Exams for Immunology

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2022/2023

Available from 05/04/2023

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52 Solved Questions on Immunology - Exam 3 | PCB 3233, Exams for Immunology
Test 3
1. Which of the following is the correct sequence:
Early Pro- B, Late Pro B, large Pre-B, small Pre-B, immature B cells
2. The light chain of the B cell receptor rearranges first and then the heavy chain rearranges?
False
3. A TCR needs other proteins associated with it to help in signaling as well as expression TCR
complex composed of?
TCR chains and the CD3 complex, including the delta chain
4. TCR’s and BCR’s both have (complimentary determining regions) CDR’s/HV’s
True
5. Gamma/delta T cells have to have antigen produced by
A. MHC class I molecules
B. MHC class II molecules
C. MHC class III molecules
D. A & B
E. None of the above
6. CD 4 and CD8 are considered and would be found on
a. Coreceptors, b-cells
b. Receptors, t-cells
c. Co-receptors, t-cells
d. Receptors, b-cells
e. Co-receptors, pathogens
7. Alpha/beta T cells are presented peptide by:
a. MHC class I molecules
b. MHC class II molecules
c. MHC class IV molecules
d. A & B
e. A, B & C
8. Burkif’s lymphoma is due to a translocation of the MYC gene next to:
a. One of the T-cell genes
b. One of the Ig genes
c. One of the MHC genes
d. All of the above
9. A peptide binding site of a MHC class II molecule can bind to peptide.
pf3
pf4
pf5
pf8

Partial preview of the text

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Test 3

  1. Which of the following is the correct sequence: Early Pro- B, Late Pro B, large Pre-B, small Pre-B, immature B cells
  2. The light chain of the B cell receptor rearranges first and then the heavy chain rearranges? False
  3. A TCR needs other proteins associated with it to help in signaling as well as expression TCR complex composed of? TCR chains and the CD3 complex, including the delta chain
  4. TCR’s and BCR’s both have (complimentary determining regions) CDR’s/HV’s True
  5. Gamma/delta T cells have to have antigen produced by A. MHC class I molecules B. MHC class II molecules C. MHC class III molecules D. A & B E. None of the above
  6. CD 4 and CD8 are considered and would be found on a. Coreceptors, b-cells b. Receptors, t-cells c. Co-receptors, t-cells d. Receptors, b-cells e. Co-receptors, pathogens
  7. Alpha/beta T cells are presented peptide by: a. MHC class I molecules b. MHC class II molecules c. MHC class IV molecules d. A & B e. A, B & C
  8. Burkif’s lymphoma is due to a translocation of the MYC gene next to: a. One of the T-cell genes b. One of the Ig genes c. One of the MHC genes d. All of the above
  9. A peptide binding site of a MHC class II molecule can bind to peptide.

a. 1 b. 2 different c. 10 different d. Many different peptides

  1. Which of the cells listed below can present peptide with MHC class II molecules? a. Mcrophages b. B cells
  1. Key difference between T cells and B cells receptors is the way the antigen is recognized? a. True b. False
  2. B cells binding to self antigens in the bone marrow can lead to the deletion or (anergy) of immune cells a. True b. False
  3. Which of the following would you expect to find as part of a Pre- B cell receptor? a. U heavy chain b. X light chain c. Ig(alpha) and Ig(beta) d. A and C e. A, B & C
  4. How many CDR’s does T cell receptors have? a. 2 b. 3 c. 4 d. 6 e. None of the above
  5. What is incorrect!?There are many similarities in B and T cell receptors, which is the different? a. V, D and J gene segment are rearranged in the heavy chain and Beta chain b. V and J gene segment are rearranged in the light chain and the alpha chain c. Both B and T cells use RAG- 1 and 2 during development d. Both B and T cells undergo somatic hypermutation e. Both B and T ells variable region genesare flanked by RSS
  6. Peptides derived from the degradation of extracellular pathogens are processed in the where they bind to. a. Endocytic vesicles; MHC class I b. Nucleus; MHC class I molecules c. Endoplasmic reticulum; MHC class II molecules d. Endocytic vesicles; MHC class II molecules e. Endoplasmic reticulum; MHC class I molecules
  7. Mature, navie B cells typically encounter anigen and are activated in the secondary lymphoid tissues. a. True b. False
  8. Which disease state is caused by loss of approx 80% of the RAG proteins enzymatic activity due to a missense mutation? a. SCID b. Omenn syndrome c. Bare lymphocyte syndrome d. AIDS

e. Burkett’s Lymphoma

  1. The 2 checkpoints in b-cell maturation take place in the bone marrow and aare when the (1) Pre- B cell receptor are made and when (2) B cell receptor is made a. True b. False
  2. During rearrangement of the variable region genes in a T or B cell, if a stop codon is added to the sequence N-nucleotide addition, what would this result in? a. Unproductive rearrangement b. Productive rearrangement c. Anergy d. Bare lymphocyte syndrome e. Somatic recombination
  3. The types of human MHC I molecules are a. HLA-A, HLA-B and HLA-C b. HLA-A, HLA-B and HLA-C c. HLA-DP, HLA- DQ, HLA-DR which present d. HLA-DP, HLA-DQ, HLA-DR which present e. None of the above
  4. B- 1 cells a. Are expressed before B- 2 cells b. Produce antibodies of limited diversity and l c. Express the cell surface glycoprotein, CD d. A & C e. A, B & C
  5. A specific T-cell receptor will only recognize a peptide presented by a specific MHC molecule but will not recognize a different peptide presented by the same MHC molecule or the same peptide presented by a different MHC molecule. The T-cell recognition of antigen is said to be: a. TCR restricted b. BCR restricted c. MHC restricted d. A & C e. None of the above
  6. RAG- 1 and RAG- 2 would be expressed in which cells a. Maturing B-cells b. Maturing T-cells c. Dendritic cells to rearrange their MHC molecules d. A and B e. A, B & C
  7. Large Pre-B cell a. Has formed a pre-b cell receptor b. Halts rearrangement of the heavy chain c. Goes through rounds of proliferation

c. Secondary lymphoid tissue d. Thymus e. Circulatory system

  1. Receptor editing is the process by which a B cell a. Produces IgA instead of IgG b. Emigrates from the bone marrow to the peripheral lymphoid tissues c. Is activated by a T cell d. A & C e. None of the above
  2. If a functional light chain gene rearrangement is made in the B cell, but it recognizes self antigen (cell might be told to enter apoptosis) the cell can be rescued by rearranging the delta chain genes and test the new receptor. a. True b. False
  3. The genetic diversity of the MHC molecules is due to: a. Genetic polymorphism b. Somatic recombination c. Class switching d. Alternative RNA splicing e. None of the above
  4. The most common TCR and an MHC II both have an alpha/beta chain a. True b. False
  5. A naïve, mature B cell: a. Has IgM, IgD and Ig alpha and beta on the surface b. Has IgM and Ig alpha/beta on the surface c. Secretes IgM only d. Secretes IgM and IgD e. None of the above
  6. You would expect to see RAG 1 and RAG 2 genes turned off during which stage of B cell development? a. Early Pro-b b. Small pre-b c. Large pre-b d. A & B e. A, B and C
  7. Cately see the release of CLIP from MHC class B molecules HLA- DM
  8. Surrogate light chain TAP 1 and TAP 2.
  9. A large cytocyte protein complex that degrades intracellular proteins to produce peptides for binding so MHC molecules Prto
  10. Occupies the peptide binding groove of MHC class II molecules to prevent peptide binding in the ER. chain
  1. Transports cytokines degraded peptides into the endoplasmic reticulum. TAP 1 and TAP 2
  2. A calcium dependent that helps MHC class I chain fold correctly and helps protect it in the ER. Cytokines