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Allergies Material Type: Notes; Class: Nursing Science 2 - Intermediate; Subject: Nursing; University: Florida Hospital College of Health Sciences;
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NRSG 230 โ Adult Health II Module 2 : Allergies Notes
Adult Health II NRSG 230 Wanda R. Forbes ARNP, MSN, MPH . Objectives
Hypersensitivities/Why? Genetic Environment The antigen ร allergen ร hypersensitivity ร allergic response Reโexposure to antigen creates ร response Hypersensitivities/What/where? FIG. 14 โ 11 Clinical manifestations of a systemic anaphylactic reaction.
IgE โ with Type 1 reaction too Skin tests Applied/skin Reaction/mins Wheal & Flare Lasts 8 โ 12 hrs Serum/specific to pt. Anaphylactic reaction risk Do NOT leave alone/testing RAST IgE antibodies/specific allergens Types/Allergic Responses TABLE 14 โ 9 Types of Hypersensitivity Reactions Type I IgE mediated reactions Rapid/exaggerated Primary contact = allergen sensitizes the B lymphocytes ร IgE antibodies produced & bind to mast cells & basophils Repeated exposure Mast cells/basophils trigger degranulation & release of chemical mediators (histamine) ร vasodilation ร โ B/P Smooth muscle contraction ร bronchial constriction
ร vascular permeability ร edema Pain/itching รmucous secretion/ body fluids Tendencies/inherited Local/systemic reaction Anaphylaxis Atopic Repeated exposureร chronic disease Anaphylaxis Systemic reaction Lifeโthreatening Allergens Drugs Bee sting Food Animal sera Death w/o immediate tx Atopic Allergic rhinitis/hay fever Asthma Atopic dermatitis Urticaria Angioedema Anaphylaxis Treatment Immediate reaction/SPEED Recognize S&S ABC Prevent spread Admin drugs Tx/shock PRN Meds Epinephrine 1: .2โ.5 ml subQ/IV.q10โ 15 min โ dose & intervals/severe reaction Diphenhydramine IV/IM H2 blockers Vasopressors Volume expanders/fluids/maintain BP Other actions Anticipate/intubation Assess airway O 2 highโflow via nonโrebreather mask Cardiac output via VS, O 2 sat, LOC, cardiac rhythm Remember: This is an emergency situation
Most effective/pollens & house dust allergies Anticipate adverse effects Missed dose/ next dose Healthcare provider/ER equipment/drugs available Type II Hypersensitivities Cytotoxic/Cytolytic Reaction Direct binding of IgG/IgM antibodies to antigen/cell surface Antigenโantibody complex/activates complement system Destroys cellular tissue/rapidly Erythrocytes/platelets/leukocytes Type II reactions include: ABO incompatibility transfusion reaction Drug related hemolytic anemias Vascular spasms/kidney/block renal tubules acute renal failure Type III Immune Complex Reaction Characterized by tissue damage Caused by activation of complement To antigenโantibody (immune) complexes/in tissues Involves IgG and IgM Reactions may be local or system/immediate or delayed Remember Secondary to antigen antibody complexes After the antigen/antibody โbattleโ โDebrisโโdestroyed tissueโis cleaned up Homeostasis restored Type III responses Clean up does not happen! Complexes deposited in tissues ร injuring tissues Kidneys/skin/joints/blood vessels/lungs Type IV Delayed Hypersensitivity Reaction CellโMediated Response Sensitized T lymphocytes attack antigens/release cytokines No antibody/complement involved Clinical examples Sensitivity to fungal/bacterial/viral infections Transplant rejection Contact dermatitis May take 24 โ 48 hours for reaction to occur Latex Allergy โ concern topts/healthcare providers Clinical/occupational health problem Reaction to certain proteins /natural rubber latex From milky fluid/rubber tree (Hevea brasiliensis)
Causes S&S range: Sneezing/runny nose โ anaphylaxis Occurs through Direct contact/ most common cause/i.e. gloves Inhalation/ latex particles Shed particles/become airborne At high Risk Children/spina bifida Healthcare workers People/history of allergies/food allergies Every hospital should have precaution protocols for latex allergy Abnormal reactions! IS believes substance/harmful โSubstancesโ aka allergens Produces IgE antibodies โ release of chemical mediators 4 types: Type I, II, III, IV Anaphylaxis: ER! Immunotherapy can help Latex allergies concern healthcare workers Need guidelines Next: Hematological Stressors!