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ANCC - PMHNP EXAM (A+
GRADE) NEWEST 2025/
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- What direct-acting dopamine receptor agonist is recommended to be used in the treatments of neuroleptic malignant syndrome (NMS) to help lower the dopamine blockade? A) Benzotropine (Cogentin) B) Bromocriptine (Parlodel) C) Dantrolene (Dantrium) D) Trihexyphenidyl (Artane) Answer: B) Bromocriptine (Parlodel) is the recommended direct-acting dopamine receptor agonist to help decrease the dopamine blockade.
- Mr. Smith is a 56-year-old white male who has been successfully treated on Selegiline for over 4 years. Mr. Smith is going in for an elective surgical procedure. Which medication is strictly contraindicated with Selegiline? A) Non-steroidal anti-inflammatory drugs (NSAIDs) B) Codeine C) Morphine D) Meperidine Answer: D) Meperidine is strictly prohibited when a patient is treated on a monoamine oxidase inhibitor (MAOI) due to the risk of hypertensive crisis and death.
- A WBC of 4,000 in a patient taking Clozapine would prompt the PMHNP to take which of the following actions? A) Consult with a hematologist to determine an appropriate antibiotic regimen and monitor closely. B) Institute twice-weekly complete blood count with differentials and monitor closely. C) Discontinue clozapine, initiate alternative antipsychotic medication, and monitor closely. D) Institute daily complete blood count with differentials and monitor closely. Answer: B) Institute twice-weekly complete blood count with differentials and monitor closely.
- A patient with a diagnosis of schizophrenia has a history of suicidal ideation and suicide attempts. The PMHNP should consider which antipsychotic medication that is the only antipsychotic to reduce the risk of suicide in schizophrenia? A) Abilify (aripiprazole) B) Latuda (lurasidone) C) Invega (iloperidone) D) Clozaril (clozapine) Answer: D) Clozaril (clozapine) is the only known antipsychotic medication that
- Which cytochrome (CYP) enzyme is implicated as a tobacco inducer when an individual is treated on clozapine? A) 1A B) 2D C) 2C D) 2C Answer: A) 1A
- When working with an avoidant patient with a history of trauma, what type of communication techniques are helpful? A) Techniques to decrease arousal B) Clarification and close-ended questions C) Techniques to increase arousal D) Reflection and open-ended questions Answer: C) Techniques to increase arousal
- The PMHNP knows that the ego is a part of the personality and is the logical/rational mind, including defense mechanisms. What might this personality part say? A) "I should" B) "I want" C) "I evaluate" D) "I ought" Answer: C) "I evaluate"
- Mr. Jones, a 78-year-old patient, presents to the PMHNP for a follow-up medication appointment. Mr. Jones' depression has been successfully treated with citalopram 20 mg by mouth daily. During the visit, Mr. Jones complains that in the last 2 or 3 weeks, he has had nausea, fatigue, feeling weak, with a headache and decreased appetite. Which action would be most appropriate for Mr. Jones? A) Assess for other symptoms of hyponatremia and check a serum sodium level. B) Discuss SSRI discontinuation syndrome and stress the importance of medication adherence. C) Discuss rates of relapse on an SSRI and increase his medication to citalopram 40 mg by mouth daily. D) Discuss rates of relapse on an SSRI and recommend switching his medication to a different class. Answer: A) Assess for other symptoms of hyponatremia and check a serum sodium level.
- The PMHNP mental health nurse practitioner treating a patient for schizophrenia on ziprasidone orders an electrocardiograph. Which QTc
interval result places the patient at greatest risk for torsades de pointes? A) 100-200 milliseconds B) 160-260 milliseconds C) 300-500 milliseconds D) 500-700 milliseconds Answer: D) 500-700 milliseconds
- Which lab test should be ordered to rule out a medical cause of dementia symptoms? A) Albumin B) Thiamine C) Vitamin D D) Vitamin B Answer: D) Vitamin B
- Which of the following lab findings would raise the greatest concern when prescribing Lithium? A) BUN 20 mg/dL B) GFR 115 mL C) Serum Creatinine 3.0 mg/dL D) Serum Na+ 120 mEq/L Answer: C) Serum creatinine 3.0 mg/dL
- A 43-year-old male is treated for Bipolar 1 on lithium. Which of the following hematologic changes is associated with lithium? A) Agranulocytosis B) Anemia C) Leukocytosis D) Leukopenia Answer: C) Leukocytosis
- Which serotonin receptor antagonism makes an antipsychotic "atypical"? A) 5HT2A B) 5HT1A C) 5HT3A D) 5HT4A Answer: A) 5HT2A
- Sally is a 27-year-old attorney who recently moved to your area. Sally presents with social anxiety disorder, specifically symptoms of performance anxiety. Sally's only other medical condition is exercise-induced asthma, and she is treated on Albuterol. Sally states she was in CBT without relief and would like to try a medication. Which is the most suitable initial
C) Give the order for the Zolpidem (Ambien). Talk with the patient about the danger of using too much sleeping medication. Then, discontinue the medication. D) Refill the order for the medication. Then, send the patient for a chemical dependency evaluation. The patient is on too many sedative-type medications and is harming themselves. Answer: B) Discontinue the prescription for Zolpidem. Talk to the patient about the overuse of Zolpidem and the danger it poses to their health and wellbeing.
- You are on call for your service. You arrive at the Emergency Dept to find a 22 - year-old male patient complaining of having trouble with his eyes. His vitals are stable. He is 5 foot 7 inches tall. His weight is 140 lbs, and his labs are all within the normal range. He states he has been taking aripiprazole (Abilify) for the last 2 months for his bipolar 1 disorder. He had the dose raised 4 days ago to manage a manic episode. He states that one to three times a day for the past 2 days, his eyes will roll upwards for 10-15 minutes, and he will have trouble seeing until they roll back down. After examination, you decide to: A) Discontinue the aripiprazole and begin the patient on a gradual regimen of Lamotrigine for 1 week. Have him return to his provider for further management of bipolar disorder. B) Continue the aripiprazole and give benzotropine mesylate. C) Discontinue the aripiprazole and give benzotropine mesylate (Cogentin) 1 mg IM. D) Begin a cross-titration downward of aripiprazole and upwards of Haldol. Answer: C) Discontinue the aripiprazole and give benzotropine mesylate (Cogentin) 1 mg IM.