ANDROGEN INSENSITIVITY
SYNDROME
BY TKSTUDYBUD
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
Guidelines and tips
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
Community
Ask the community
Ask the community for help and clear up your study doubts
University Rankings
Discover the best universities in your country according to Docsity users
Free resources
Our save-the-student-ebooks!
Download our free guides on studying techniques, anxiety management strategies, and thesis advice from Docsity tutors
Androgen Insensitivity Syndrome: A Comprehensive Overview, Slides of Medicine
A comprehensive overview of androgen insensitivity syndrome (ais), a genetic disorder affecting male hormone physiology. It delves into the causes, types, clinical features, investigations, differential diagnosis, and management of ais. How mutations in the androgen receptor gene lead to resistance to testosterone, resulting in female external genitalia despite a male genotype. It also discusses the different types of ais, including complete, partial, and mild insensitivity, and their associated clinical manifestations. The document further outlines the diagnostic procedures, including chromosomal analysis, hormone testing, and imaging studies, as well as the medical and surgical management options for ais.
Typology: Slides
2022/2023
1 / 9
This page cannot be seen from the preview
Don't miss anything!
Related documents
Partial preview of the text
Download Androgen Insensitivity Syndrome: A Comprehensive Overview and more Slides Medicine in PDF only on Docsity!
ANDROGEN INSENSITIVITY
SYNDROME
BY TKSTUDYBUD
ANDROGEN INSENSITIVITY SYNDROME
It is an X linked recessive disorder with mutation in androgen receptorgene.
It may lead to a female appearance in genetic males (XY).
These individuals have a male (XY) genotype, testes, and female orambiguous external genitalia. This is caused by abnormalities in someaspect of male hormone physiology in the fetus.
In this disorder, the genes that produce androgen receptors havemutations, and the resulting androgen receptors are resistant totestosterone. So the fetal tissues fail to respond to testosteroneeven though it’s produced in sufficient amounts in the fetal testes.
The lack of testosterone effect leads to the development ofundifferentiated external genitalia into female structures.
TYPES OF ANDROGEN INSENSITIVITYSYNDROME
CAIS (completely insensitive to AR gene) EXTERNAL FEMALE GENITALIALACK FEMALE INTERNAL ORGANS ( SERTOLI CELL MARKERS ANTI MULLERIANHORMONE AND INHIBIN B PRESENT)
PAIS ( partially sensitive- varying degrees) EXTERNAL GENITALIA APPEARANCE ON SPECTRUM ( PHENOTYPIC WOMEN WITHMILD VIRILIZATION TO PHENOTYPIC MEN WITH UNDERVIRILIZATION ANDGYNECOMASTIA OR INFERTILITY)
MAIS (mildly sensitive) IMPAIRED SPERM DEVELOPMENT OR IMPAIRED MASCULINIZATION