Anticoagulants: Classification, Mechanism of Action, and Therapeutic Uses, Slides of Pharmacology

Download Anticoagulants: Classification, Mechanism of Action, and Therapeutic Uses and more Slides Pharmacology in PDF only on Docsity!

PRESENTATION ON ANTI COAGULATNS

CONTENTS

Introduction

Classification of Anticoagulants

Pathways

Mechanism of action

Therapeutics Uses

Adverse Effects

Classification of Anti Coagulants 1) USED IN VIVO: A) PARENTERAL ANTICOAGULANTS: (a)INDIRECT THROMBIN INHIBITORS : Heparin Low molecular weight heparins Fondaparinux Danaparoid (b) DIRECT THROMBIN : Lepirudin Bivalirudin Argatroban

B) ORAL ANTICOAGULANTS:

COUMARIN DERIVATIVES:

Bishydroxcoumarin (dicumarol) Warfarin sodium Acenocoumarol DIRECT FACTOR Xa INHIBITORS: Ethylbiscoumacetate Rivaroxaban ORAL DIRECT THROMBIN INHIBITOR: Dabigatran, etexilate

Pathways:

Mechanism of important drugs used in anti coagulatns:  (^) ANTICOAGULANT ACTION OF HEPARIN: HEPARIN Activates plasma AT Il Heparin-AT Ill complex Binds to clotting factors of intrinsic and common pathways (Xa, la, IXa, Xla, Xlla and Xllla) and inactivates them

WARFARIN MOA:

Warfarin and its congeners act as anticoagulants only in vivo, not in vitro. This is so because they act indirectly by interfering with the synthesis of vit K dependent clotting factors in liver. They apparently behave as competitive antagonists of vit K and lower the plasma levels of functional clotting factors in a dose-dependent manner. In fact, they inhibit the enzyme vit K epoxide reductase (VKOR) and interfere with regeneration of the active hydroquinone form of vit K (Fig. 45.2) which acts as a cofactor for the enzyme γ-glutamyl carboxylase.

Fig:moa of oral anticoagulant

REFERENCE: “ESSENTIAL OF MEDICAL PHARMACOLOGY” TH Edition By KD Tripathi,Page no:

THANK YOU