Docsity
Docsity

Prepare for your exams
Prepare for your exams

Study with the several resources on Docsity


Earn points to download
Earn points to download

Earn points by helping other students or get them with a premium plan


Guidelines and tips
Guidelines and tips

Antifungal Agents and Their Mechanisms of Action, Quizzes of Medical Microbiology

Definitions and mechanisms of action for various antifungal agents, including sordarin or azasordarin, echinocandins (caspofungin, anidulafungin, micafungin), nikkomycin z, imidazoles (ketoconazole, clotrimazole), triazoles (fluconazole, itraconazole, voriconazole), tolnaftate (tinactin) and allylamines (terbinafine), amphotericin b and nystatin, and griseofulvin, as well as flucytosine and its mode of action.

Typology: Quizzes

2010/2011

Uploaded on 10/11/2011

kdoerr4054
kdoerr4054 🇺🇸

3

(1)

6 documents

1 / 2

Toggle sidebar

This page cannot be seen from the preview

Don't miss anything!

bg1
TERM 1
Sordarin or Azasordarin
DEFINITION 1
Inhibits ribosome GTPase (EF-2)targets protein synthesis
TERM 2
Caspofungin, Anidulafungin, Micafungin
(Echinocandins)
DEFINITION 2
inhibits beta-(1,3) glucan synthasetargets cell wall synthesis
TERM 3
Nikkomycin Z
DEFINITION 3
inhibits chitin synthasetargets cell wall synthesis
TERM 4
Imidazoles - Ketoconazole, Clotrimazole
(Lotrimin), Miconazole (Monistat)
DEFINITION 4
inhibits 14-alpha-demthylasetargets ergosterol synthesis2 N
in azole ring
TERM 5
Triazoles - Fluconazole, Itraconazole,
Voriconazole
DEFINITION 5
inhibits 14-alpha-demthylasetargets ergosterol synthesis3 N
in azole ring
pf2

Partial preview of the text

Download Antifungal Agents and Their Mechanisms of Action and more Quizzes Medical Microbiology in PDF only on Docsity!

TERM 1

Sordarin or Azasordarin

DEFINITION 1

Inhibits ribosome GTPase (EF-2)targets protein synthesis

TERM 2

Caspofungin, Anidulafungin, Micafungin

(Echinocandins)

DEFINITION 2

inhibits beta-(1,3) glucan synthasetargets cell wall synthesis

TERM 3

Nikkomycin Z

DEFINITION 3

inhibits chitin synthasetargets cell wall synthesis

TERM 4

Imidazoles - Ketoconazole, Clotrimazole

(Lotrimin), Miconazole (Monistat)

DEFINITION 4

inhibits 14-alpha-demthylasetargets ergosterol synthesis2 N

in azole ring

TERM 5

Triazoles - Fluconazole, Itraconazole,

Voriconazole

DEFINITION 5

inhibits 14-alpha-demthylasetargets ergosterol synthesis3 N

in azole ring

TERM 6

Tolnaftate (tinactin) and Allylamines

(Terbinafine (Lamisil))

DEFINITION 6

inhibits squalene epoxidasetargets ergosterol synthesis

TERM 7

Amphotericin B and Nystatin (Polyenes)

DEFINITION 7

binds ergosterol directly and upon binding forms a pore to

destroy osmotic integritytargets cell membrane

TERM 8

Griseofulvin

DEFINITION 8

targets microtubules disrupting the mitotic spindle resulting

in inhibition of mitotic activitiestargets mitosis

TERM 9

Flucytosine

DEFINITION 9

deaminates to 5-fluorouracil in fungus

competes with uracil in the synthesis of RNA

replaces C during synthesis of DNA

targets nucleic acid syntheis