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Lysosomal and Peroxisomal Disorders and Antiretroviral Drugs: Definitions and Mechanisms, Quizzes of Pharmacology

Lake Erie College of Osteopathic Medicine (LECOM)Pharmacology

Definitions and mechanisms of various lysosomal and peroxisomal disorders, including chediak-higashi syndrome, i-cell disease, tay sachs, pompe, familial isolated growth hormone deficiency, cystinuria, hartnups disease, zellweger syndrome, neonatal adrenoleukodystrophy (ald), infantile refsum disease, and others. Additionally, it covers antiretroviral drugs such as alpha amanitin, rifampin, actinomycin d, acridine, b thalassemia, systemic lupus erythematosis, and their mechanisms of action. Terms related to the structure of nucleotides are also included.

Typology: Quizzes

2013/2014

Uploaded on 11/09/2014

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TERM 1
Chediak-Higashi Syndrome
DEFINITION 1
Defect in microtubule polymerization
TERM 2
I-Cell disease
DEFINITION 2
Mucolipidosis IIa lysosomal storage disorder diseasedisorder
of protein where lysosomal proteins are not sorted
TERM 3
Tay Sachs
DEFINITION 3
A lysosomal storage diseaseaccumulation of partially
digested gangliosides in lysosomes
TERM 4
Pompe
DEFINITION 4
A lysosomal storage diseaseAccumulation of particles in
lysosomes
TERM 5
Familial isolated growth hormone defieciency
DEFINITION 5
disease caused by diruption of pre-mRNA splicing
pf3
pf4
pf5

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Chediak-Higashi Syndrome

Defect in microtubule polymerization

TERM 2

I-Cell disease

DEFINITION 2

Mucolipidosis IIa lysosomal storage disorder diseasedisorder

of protein where lysosomal proteins are not sorted

TERM 3

Tay Sachs

DEFINITION 3

A lysosomal storage diseaseaccumulation of partially

digested gangliosides in lysosomes

TERM 4

Pompe

DEFINITION 4

A lysosomal storage diseaseAccumulation of particles in

lysosomes

TERM 5

Familial isolated growth hormone defieciency

DEFINITION 5

disease caused by diruption of pre-mRNA splicing

Cystinuria

A disease resulting from a transporter defect-impaired

reabsorption of dibasic amino acids

TERM 7

Hartnups disease

DEFINITION 7

diseases that can result from transporter defects-impaired

reabsorption of tryptophan

TERM 8

Zellweger syndrome

DEFINITION 8

disease that results from failure to oxidize long fatty acid

chainsdecrease peroxisome in liver, brain, and kidney

TERM 9

Neonatal adrenoleukodystrophy (ALD)

DEFINITION 9

peroxisomal disorder (failture to degrade fatty

acids)progressive brain damage

TERM 10

Infantile Refsum disease

DEFINITION 10

peroxisomal disorderMalformation of myelin sheath around

nerve cells

Cytosine major and minor groove

Major: N4Minor C

TERM 17

Adenine major and minor groove

DEFINITION 17

Major: N6, N7Minor: N

TERM 18

Thymine major and minor groove

DEFINITION 18

Major,C4 carbonyl, C5 methylminor C2 carbonyl

TERM 19

Uracil Major and Minor Grooves

DEFINITION 19

Major groove: C4 carbonyl, N7Minor Groove: C

TERM 20

Guanine Major and Minor Grooves

DEFINITION 20

Major groove: C6 N7Minor: N2 N

Mechanism for enfuvirtide

Blocks by fusion inhibitersblocks entry of HIV into cell

TERM 22

Mechanism of nelfinavir

DEFINITION 22

Blocks by protease + maturation inhibitorsStops

noninfections virion from becoming mature infectious virions

by stopping proteolytic cleavage

TERM 23

What antiretroviral drugs block by

NRTIS

DEFINITION 23

AZT- zidovudineDDL- didanosineDDC- Zalcitabineall stop

reverse transcription from copying the single stranded HIV

RNA genome into double stranded DNA

TERM 24

What Antiretroviral uses NNRTIS to combat

HIV

DEFINITION 24

NEvirapineBLocks reverse transcriptase from from copying

single stranded RNA into double stranded DNA

TERM 25

What is the antiretroviral mechanism of

maraviroc

DEFINITION 25

Blocks CCR5 receptor so virus cannot bind