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A comprehensive set of questions and answers covering various aspects of virology, including viral structure, life cycle, and specific examples of viral diseases. It is designed to help students prepare for an exam in a biology course, specifically focusing on the topic of viruses. Multiple-choice questions, true/false statements, and short answer questions, providing a diverse range of assessment methods.
Typology: Exams
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True or False. Because the genome is contained within an enclosed space (much like the nucleus of a cell), viruses are classified as eukaryotic. True False False. Viruses are neither eukaryotic nor prokaryotic.
Describe the two basic components of a virus. Your Answer:
The envelope surrounds the of some viruses. Your Answer: capsid capsid
True or False. You would expect to see a viral envelope on a virus infecting a plant cell.
False False. The viral genome is never replicated before attachment and entry regardless of its level of infectivity. Place the following viral life cycle steps in order beginning with viral attachment and provide a description of each step. Uncoating: Release: Replication: Attachment: Entry: New infection: Your Answer: Attachment Entry Uncoating Replication New infection Released 3 - Uncoating: the viral capsid disassembles 5 - Release: New virus particles are produced and leave the cell 4 - Replication: the viral genome is the ‘blueprint’ to make copies of itself 1 - Attachment: viral receptors bind to host proteins on the surface of the cell 2 - Entry: the virus fuses with the host membrane and enters the cell
6 - New infection: newly produced viruses that left the host cell now go on to infect new cells. provide a description of each step
A virus that infects bacteria is called a [answer1] and contains a [answer2] - sided polygon capsid. Your Answer:
**1. Bacteriophage
True or False. Structurally, bacteriophages are distinct from viruses that infect plant or animal cells. True True. Bacteriophages are structurally distinct from viruses that infect plant and animals cells. False
Identify the following components of a bacteriophage.
Describe the main differences between lytic and temperate phages. Your Answer: lytic bacteriophage replicate within host bacteria till they lyses, but temperate or lysogenic bacteriophage can survive in non replicative state and its viral genome integrated in to host genome Lytic bacteriophages replicate within the host bacteria until it ruptures, whereas temporate (or lysogenic) phages primarily exist in a non-replicative state that does not kill the host cell. Lytic phages replicate all viral proteins needed for the assembly of new virus particles whereas lysogenic phage genomes are integrated into the host genome but production of viral proteins is suppressed.
4 - Base plate 5 - Tail fibers Based on the following image, would you expect the viral titer to be high or low? Why?
Which of the following can be spread via airborne particles: Measles Mumps Rubella Your Answer: Low. As turbidity is a function of the number of intact bacterial cells present in the media, the amount of virus contained within the above tube must be low. As the lytic cycle continues more and more bacterial cells will be destroyed, effectively clearing the media. A and B
A patient may experience a combination of symptoms such as fever, flu-like symptoms (influenza), cough, conjuctivitis, and a red blotchy skin rash.
Which of the following diseases does a linear, single-stranded RNA virus cause? Measles Mumps Rubella B and C All of the above Measles, mumps and rubella are all linear, single-stranded RNA viruses.
What disease displays as a secondary characteristic swelling of the testes/ovaries and pancreas? Your Answer: Mumps Mumps. A patient infected with mumps (aka epidemic paratitis) has primary swelling in the paratoid (salivary glands) located in the neck but also may have secondary swelling in the testes/ovaries and pancreas. Question 18
Describe two ways chickenpox can be spread. Your Answer:
True or False. The development of shingles is most often seen in an older adult population (> 60 years old). True True. The most common age for VZV reactivation and shingle diagnosis tends to occur in people around 60 years of age. False
True or False. Similar to chickenpox, the blisters that appear with shingles can cover the entire body. True False False. Unlike chickenpox blisters, which can form anywhere, the blisters associated with shingles are localized and limited to small areas.
By whom and where was the first polio vaccine developed? Your Answer: Jonas Salk in pitsburg university Jonas Salk and his research team developed the polio vaccine at the University of Pittsburgh in 1955.
Which subtype of Influenza is the most virulent? Your Answer: subtype A Influenza A
A drug company is trying to develop a new drug that will inhibit the release of newly produced viral particles. Would the drug company target hemagglutinin proteins or neuraminidase proteins? Why? Your Answer: Neuraminidase protein because this protein is responsible for release of new viral particles from host cells but the Hemaglutinin protein involves in the entry of the viral particle to the host cell Neuraminidase (N) proteins are directly involved in the budding and release of new viral particles and would thus be the correct target. Hemagglutinin (HA) proteins would not be advisable targets as they are directly involved in viral attachment and entry into the host cell.
Explain why the flu shot given each year may not be 100% effective at preventing the flu? Your Answer: till now 16 subtype of hemaglutinin and 9 subtype of neuraminidase have been discovered and can be shown on different combination of viral envelope, so all HA and
True or False. The viral capsid of HIV is dumbbell shaped and contains ~2,000 copies of the viral protein p24. True False False. The HIV capsid is conical (cone) shaped.
The HIV surface glycoprotein gp41 binds what host cellular receptor? CD CXCR HIV gp41 binds to the receptor CXCR N cannot present on each virion. So due to large number of possibility of variants flu vaccine cannot be protective against all subtype and a person who received a flu shot has the probability to gain flue disease It is possible to receive a flu vaccine and yet (unfortunately) still get the flu in the same season if you are exposed to a viral strain that was not included in the vaccine. There are a large number of variants and the flu vaccine is unable to vaccinate against all subtypes. Medical researchers predict and then distribute flu vaccines based current trends and the available data relative to the most common circulating strains. Unfortunately, this model is not always 100% accurate. CD