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Cartilage and Bone, Exercises of Biochemistry

Magdalen College Biochemistry

Types of cartilage (hyaline, fibrocartilage, elastic) are distinguished by the characteristics of their matrix (e.g., the dominant type of protein fiber). 3 ...

Typology: Exercises

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Lab6–CartilageandBone

A560– Fall2015

I. Introduction

II. LearningObjectives

III. SlidesandMicrographs

A. Cartilage

1. Hyaline

2. Fibrocartilage

3. Elastic

B. Bone

1. Woven

2. Lamellar

a. Compact

b. Cancellous(seenlater)

IV. Summary

CartilageandBone

Lightmicrographofhumanboneincrosssectionunderpolarizedlight– KentWoodPhotography

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Download Cartilage and Bone and more Exercises Biochemistry in PDF only on Docsity!

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides and MicrographsA. Cartilage

Hyaline2. Fibrocartilage3. Elastic B. Bone 1. Woven2. Lamellar a. Compactb. Cancellous (seen later) Summary

Cartilage

and

Bone

Light micrograph of human bone in cross section under polarized light – Kent Wood Photography

Cartilage

and

Bone

1.^

Cartilage

is

a

specialized

type

of

solid

connective tissue which, along with bone, isdistinguished

by

its

relative

rigidity

of

the

extracellular matrix (ECM); it is distinguishablefrom bone by its

avascularity

2.^

Types

of^

cartilage

(hyaline,

fibrocartilage,

elastic) are distinguished by the characteristicsof^

their

matrix

(e.g.,

the

dominant

type

of

protein fiber)

3.^

Bone

is a specialized type of solid connective

tissue characterized by a

mineralized ECM

that

stores calcium and phosphate

4.^

Woven (immature) bone differs from lamellar(mature) bone in its collagen fiber arrangement;woven bone is replaced by lamellar bone inadults, with few exceptions

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides and MicrographsA. Cartilage

Hyaline2. Fibrocartilage3. Elastic B. Bone 1. Woven2. Lamellara. Compactb. Cancellous (seen later) Summary

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A.^ Cartilage 1.^ Hyaline 2. Fibrocartilage3. Elastic B. Bone

Woven2. Lamellara. Compactb. Cancellous (seen later) Summary

Slide 2: Trachea, Trichrome

Look here for hyaline

cartilage

What kind ofepithelium ispresent here?

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A.^ Cartilag

1.^ Hyaline 2. Fibrocartilage3. Elastic B. Bone 1. Woven2. Lamellara. Compactb. Cancellous (seen later) Summary

Slide 2: Trachea, Trichrome

hyalinecartilage Greek

=^ “glassy”

perichondrium

Hyaline cartilage

, the most common type, contains the smallest proportion of fibers

in the ECM – giving it a homogenous, glassy appearance; it is rich in

Type II collagen

and

aggrecan

complexes (chondroitin sulfate and keratan sulfate) with bound water

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A.^ Cartilage 1.^ Hyaline 2. Fibrocartilage3. Elastic B. Bone

Woven2. Lamellara. Compactb. Cancellous (seen later) Summary

Slide 2: Trachea, Trichrome

chondroblasts

chondrocytes

(cells)

located in lacunae

(spaces)

perichondrium

hyaline

cartilage

Dividing cells are called

chondroblasts

and

chondrocytes

once proliferation has ceased; both

have

basophilic cytoplasm rich in rER

for collagen synthesis; production of the ECM encloses the

cells in their lacunae (Lt. “

little lake

”); chondrocytes synthesize and maintain ECM components

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A.^ Cartilage 1.^ Hyaline 2. Fibrocartilage3. Elastic B. Bone

Woven2. Lamellara. Compactb. Cancellous (seen later) Summary

Slide 7: Larynx, Trichrome

look here for hyaline

cartilage

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A.^ Cartilage 1. Hyaline2.^ Fibrocartilage

Elastic B. Bone 1. Woven2. Lamellar a. Compactb. Cancellous (seen later) Summary

Slide 131: Fibrocartilage, H&E

Fibrocartilage

is characterized by a matrix containing a

combination of dense CT (Type I/II collagen

fibers) and hyaline cartilage

; relative scarcity of proteoglycans makes the matrix of fibrocartilage

acidophilic than that of hyaline or elastic cartilage

; there is

no distinct surrounding perichondrium

in

fibrocartilage; it is found in intervertebral discs, in attachments of certain ligaments, and in the pubicsymphysis

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A.^ Cartilage 1. Hyaline2. Fibrocartilage3.^ Elastic B. Bone

Woven2. Lamellar a. Compactb. Cancellous (seen later) Summary

Slide 56: Elastic Cartilage, H&E, AF

Look herefor

elastic

cartilage Elastic cartilage

is

essentially similar to hyaline cartilage

except that it contains an abundant

network of elastic fibers in addition to Type II collagen; visualization of the elastic fibers usuallyrequires special stains; it is found in the auricle of the ear, the walls of the external auditory canals,the auditory (Eustachian) tubes, the epiglottis, and the cuneiform cartilage in the larynx

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A.^ Cartilage 1. Hyaline2. Fibrocartilage3.^ Elastic B. Bone

Woven2. Lamellara. Compactb. Cancellous (seen later) Summary

Slide 56: Elastic Cartilage, H&E, AF

Dark areaaround cells = elastic

fibers

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A.^ Cartilage 1. Hyaline2. Fibrocartilage3.^ Elastic B. Bone

Woven2. Lamellar a. Compactb. Cancellous (seen later) Summary

Slide 87: Epiglottis, Masson AF

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A. Cartilage

Hyaline2. Fibrocartilage3. Elastic B.^ Bone 1. Woven2. Lamellara.

Compact b. Cancellous (seen later) Summary

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A. Cartilage

Hyaline2. Fibrocartilage3. Elastic B.^ Bone 1. Woven2. Lamellara.

Compact b. Cancellous (seen later) Summary

Slide 32: Ground Bone

Transversesection

Longitudinal

section

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A. Cartilage

Hyaline2. Fibrocartilage3. Elastic B.^ Bone 1. Woven2. Lamellara.

Compact b. Cancellous (seen later) Summary

Slide 32: Ground Bone

lamellae (rings)

osteocytes

(cell) in

lacunae

(space)

interstitial lamellae central^ canal small, darklines = canaliculi

Transverse section

Within each

osteon

, osteocytic

lacunae

occur

between the lamellae

, with

canaliculi

(Lt. “

small

channels

”) radiating through the lamellae, which

allow all cells to communicate with the central

canal

; interstitial lamellae are remnants of osteons partially resorbed during bone remodeling

Lab

6 – Cartilage

and

Bone

A560 – Fall 2015

Introduction Learning Objectives Slides

and

Micrographs

A. Cartilage

Hyaline2. Fibrocartilage3. Elastic B.^ Bone 1. Woven2. Lamellara.

Compact b. Cancellous (seen later) Summary

Slide 32: Ground Bone

Transverse section

Cartilage and Bone, Exercises of Biochemistry

Related documents

Partial preview of the text

Download Cartilage and Bone and more Exercises Biochemistry in PDF only on Docsity!

Cartilage

and

Bone

Cartilage

and

Bone

1.^

Cartilage

is

a

specialized

type

of

solid

connective tissue which, along with bone, isdistinguished

by

its

relative

rigidity

of

the

extracellular matrix (ECM); it is distinguishablefrom bone by its

avascularity

2.^

Types

of^

cartilage

(hyaline,

fibrocartilage,

elastic) are distinguished by the characteristicsof^

their

matrix

(e.g.,

the

dominant

type

of

protein fiber)

3.^

Bone

is a specialized type of solid connective

tissue characterized by a

mineralized ECM

that

stores calcium and phosphate

4.^

Woven (immature) bone differs from lamellar(mature) bone in its collagen fiber arrangement;woven bone is replaced by lamellar bone inadults, with few exceptions

Look here for hyaline

cartilage

What kind ofepithelium ispresent here?

hyalinecartilage Greek

=^ “glassy”

perichondrium

Hyaline cartilage

, the most common type, contains the smallest proportion of fibers

in the ECM – giving it a homogenous, glassy appearance; it is rich in

Type II collagen

and

aggrecan

complexes (chondroitin sulfate and keratan sulfate) with bound water

chondroblasts

chondrocytes

(cells)

located in lacunae

(spaces)

perichondrium

hyaline

cartilage

Dividing cells are called

chondroblasts

and

chondrocytes

once proliferation has ceased; both

have

basophilic cytoplasm rich in rER

for collagen synthesis; production of the ECM encloses the