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Just the highlights of Cellular Respiration
Typology: Cheat Sheet
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Cellular Respiration Cheat Sheet - Just the highlights of Cellular Respiration
General formula: C 6 H 12 O 6 + 6 O 2 → 6 CO 2 + 6 H 2 O + 32 ATP
Overall Point: Cellular respiration uses Oxygen to break down sugar and make ATP (cell energy)
Note : Very few cells actually produce 32ATP, most produces some number less than that.
There are four major steps to Cellular Respiration
Step 1. Glycolysis
C 6 H 12 O 6 is broken in half using 2 ATP → 2 Pyruvate + 2 NADH + 4 ATP
Where does this step occur?: In the cell's cytoplasm
Overall Point of this step: To break sugar and produce a small amount of ATP (cell energy)
Step 2. Oxidation of pyruvate to produce Acetyl-CoA
For each Pyruvate created in step 1 (so 2 times per glucose)
Pyruvate +NAD + CoEnzyme A (CoA) → Acetyl-CoA + NADH + CO 2
Where does this step occur?: Crossing from the cells cytoplasm into the Mitochondria
Overall Point of this step: To take the Pyruvate created in Glycolysis and make it smaller, and shaped correctly to enter the Mitochondria.
Step 3. Krebs Citric Acid Cycle :
For each Acetyl-CoA from step 2 (so 2 times per glucose)
Acetyl -CoA + 3 NAD+ 1 FAD+ → 1 ATP + 3 NADH + 1 FADH 2
Where does this step occur?: In the Stroma (fluid part) of the mitochondria
Overall Point of this step: To break up the remainder of the original glucose (the Acetyl-CoA) to create NADH and FADH 2 (the electron carriers)
Before you go on, we need to figure out what we have created so far:
6 CO2 (this actually accounts for all of the Carbon in glucose that we started with!)
10 NADH (electron carrier)
2 FADH2 (also an electron carrier)
4 ATP (cellular energy)
Step 4. The Electron Transport Chain and Chemiosmosis
Where does this step occur?: On the Cristae of the Mitochondria (the mitochondrial inner membranes)
Overall Point of this step: This step takes the H+ off of all of the NADH and FADH 2 that the previous steps have created and uses it along with Oxygen to power the production of ATP.
The protein NADH Dehydrogenase (which really just means NADH enzyme that pulls the hydrogen off) in the cristae pull the H+ off of NADH creating NAD+. This also happens to FADH 2 creating FAD+.
The H ions that have been pulled off of the electron carriers are put into the inner membrane space of the mitochondria. This makes one side of the membrane acidic (lots of H+) and one side less acidic. Membranes HATE to have one side higher in acid than the other! (remember when we looked at osmosis and water passes through a membrane to try and even out salt solutions on both side of the membrane?)
This difference in acidity (H+) is used to slowly pass some H+ to an Oxygen molecule. As the H+ passes from one side of the membrane to the other, it spins ATP syntheses.
ATP synthase is a protein complex that makes ATP when it spins.
The Oxygen that you breathe is used in this very last step to force the H+ across the membrane. If there is no oxygen here to pull the H+, there will be very little ATP created. This is why you breathe Oxygen. If I take away your O 2 you stop producing large numbers of ATP, your brain runs out of ENERGY and you die.