Comprehensive Dosage Form Design Notes – Clear, Concise & Exam-Ready, Study notes of Biopharmaceutics and Pharmacokinetics

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DESIGN OF DOSAGE FORM Principles of dosage form design: Administration route/Desage forms Oral - Solutions, syrups, suspensions, emulsions, gels, powders, granules, capsules, tablets Rectal - Suppesitories, cintments, creams, powders, solutions Topical - Ointments, creams, pastes, lotions, gels, solutions, topical aerosols, foams, transdermal patches Parenteral - Injections (solution, suspension, emulsion forms), implants, irrigation and dialysis solutions Respiratory - Aerosols (solution, suspension, emulsion, pewder forms), inhalations, sprays, gases Nasal - Solutions, inhalations Eye - Solutions, ointments, creams Ear — Solutions, suspensions, ointments, creams ~ There are numerous desage forms inte which a drug substance can be incorporated for the convenient and efficacious treatment of a disease. ~ Dosage forms can be designed for administration by a variety of delivery routes to maximize therapeutic response. ~ Many drugs are formulated inte several desagenforms of various strengths, each having selected pharmaceutical characteristics which are suitable for a specific application. One such drug is the glucecerticoid prednisolone used in the suppression of inflammatory and allergic disorders. -Through the use of different chemical forms and formulation additives, a range of effective anti- inflammatory preparations are available, including tablets, gastro-resistant coated tablets, injections, eye drops and enemas. — The extremely low aqueous solubility of the base prednisolone and its acetate salt makes these forms useful in tablet and slowly absorbed IM suspension injection forms, whilst the soluble sodium phosphate salt enables preparation of a soluble tablet form and solutions for eye and ear drops, enemas and IV injections. ~ The analgesic paracetamol is alse available in a range of dosage forms and strengths to meet the specific needs of the user, including tablets, dispersible tablets, paediatric soluble tablets, paediatric oral solution, sugar-free oral solution, oral suspension, double strength oral suspension and