[ ] MINERALIZATION- it’s the process by which minerals are deposited in
organic matrix
• Its one of the important step in formation of hard tissue matrix
(Enamel, Dentin, Cementum,Bone)
●Although , tissue fluid is supersaturated with Ca & P Ions, spontaneous
precipitation of calcium phosphate does not take place BECAUSE:-
1 . Presence of substance inhabiting crystal formation
2.Unstable and Inadequate mass of crystals that dows not initiate
mineralisation
3.Furthermore, the formation of clusters of ions Requires the expenditure
of energy and an energy Barrier must be overcome for crystallization
which is not present in subsequent amount in tissue fluid
● Inorganic component of mineralized tissue Consist of mainly: calcium
hydroxyapatite
Ca10(P04)6OH)2
• Unit cell - least no. of Ca, phosphate and hydroxyl ions able to establish
a stable ionic relationship.
• Shape-hexagonal
• Unit cells stacked together to form a lattice .Repitition of lattice forms a
needle like or ribbon like structures
[ ] PROCESS OF MINERALISATION:
Occurs by aggregation of ions to form CRYSTAL . Process is termed as
nucleation
HOMOGENOUS NUCLEATION:
Local increase in the concentration of mineral ions
•formation pf sufficient crystals required for mineralisation
HETEROGENOUS NUCLEATION:
•Presence of nucleating subsrances
• Nucleators act as template
