Determining a Consensus Sequence Activity, Lecture notes of Genetics

Determining a Consensus Sequence Activity Page 1

A consensus sequence is determined by aligning many nucleotide (or protein) sequences

that share a common function, then determining the most commonly expressed nucleotide

(or amino acid) at each position. Often conserved sequences reflect a common function or

binding domain. In this exercise you will identify important nucleotides in the region for the

initiation of translation.

Below is a table that lists the nucleotide sequence surrounding the AUG start codon

(highlighted) for ten human genes. For each column, tally the frequency of each nucleotide