Download Connective Tissue Diseases: Marfan, Ehlers-Danlos, and Scurvy and more Quizzes Physiotherapy in PDF only on Docsity!
Non-Inflammatory CT Disease
caused by genetic disorders or nutrional issueslesion is due to a dysfunction in synthesizing either collagen fibrillin/elasticmanifests as impaired collagen results in unstable and weak collagen fiber bundles and result in CT weakness TERM 2
Non-Inflamm Causes Genetic
DEFINITION 2 genetic disorder of specific protein syntheses of collagen, elastic, synth by fibroblastsmarfan's syndrome-autosomal dom involves body fibroblastsehlersDanlos sundrome- autosomal dom, o TERM 3
Non Inflamm Causes Nutritional
DEFINITION 3 scurvyloss of or lack of vitamin c, collagen synthesizing cofactorw/o c collagen will not be formed effectively TERM 4
Mafran's Syn
Lesion
DEFINITION 4 impaired fibillin synthesis which decreases stabilitic of elastic fibers TERM 5
Ehlers Danlos Syndrom
Lesion
DEFINITION 5 affects synth of collagen resulting in weak tissue fiber bundles
scurvy lesion
vit c is necessary cofactor for the stabilization of collagen fibers after synth TERM 7
Marfan Summary
DEFINITION 7 non inflammatoryautosomal dominantimpaired fibillin synth which decreases stability of elastic fibersmanifests as weak blood vessel walls-aorta rupture, skeletal abnormalities dure to weak bone CT, joint hypermobilitycharacterized by long fingers TERM 8
EhlersDanlos Summary
DEFINITION 8 noninflammatory CT diseaseautosomal dominantaffects synthesis of collagen resulting in weak tissue fibermanifests as weak blood vessel walls/aorta rupture, joint hypermobilitiy-being double jointed, fragile skin susceptible to bruising and bleeding, poor wound healing usually utilizing secondary intention TERM 9
Scurvy Summary
DEFINITION 9 noninflammdue to lack of vit cnecessary for stabilization of collagen fibers after synth-post translationalmanifests as fragile skin susceptible to bleeding and poor wound healing TERM 10
Inflamm CT disease
DEFINITION 10 mixed connective tissue disease
BM thickens
impairs the transfer of nutrients and impairs capillary permeability TERM 17
Lupus manifestations
DEFINITION 17 prevalence highest in young to middle age womenskin rash butterfly over cheeks-wolfbite-->lupusarthritis from synovial inflammationgolmerulonephritis from vasculitis and /or BMpulmonary dysfunction from vasculitis and/or BMblood disorders-anemia, decreased leukocytes and platelets TERM 18
Systemic Sclerosis/Scleroderma
DEFINITION 18 specific to skin whereas lupus is widespreadcaused by an autoimmune reaction where lymphocytes respond to unknown antigen in skin CTresults in the release of inflamm cytokines TERM 19
Scleroderma Lesions
DEFINITION 19 increased collagen production and depositsdermis layer is mostly affectedvasculitis is common TERM 20
Scleroderma Manifestations
DEFINITION 20 dermis is thick and restrictedskin ulcers and calcificationGI Kidney and respiratory systems are also affected
