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DNA Mutations Practice Worksheet, Exercises of Genetics

Typology: Exercises

2020/2021

Uploaded on 04/20/2021

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DNA Mutations Practice Worksheet
DIRECTIONS: Transcribe and translate the original DNA sequence. Then, do the same for each
mutated DNA sequence. Then, determine the consequence, if any, for each mutation, by
circling your choice for each question. You will need a Genetic Code Chart.
Original DNA
sequence:
TAC
ACC
TTG
GCG
ACG
ACT
mRNA transcript:
amino acids:
Mutated DNA
sequence #1:
TAC
ATC
TTG
GCG
ACG
ACT
mRNA transcript:
(Circle any changes)
amino acids:
Type of
mutation
(Circle one.)
Point
Frameshift
Insertion
or
Deletion
How did the
mutation affect
the amino acid
sequence
(protein)?
(Circle one.)
No change
1 amino
acid
changed
Premature
stop signal
No stop
signal
1 amino acid
added/
deleted
All the amino acids
changed after the
point of mutation
Mutated DNA
sequence #2:
TAC
GAC
CTT
GGC
GAC
GAC
T
mRNA transcript:
(Circle any changes)
amino acids:
Type of
mutation
(Circle one.)
Point
Frameshift
Insertion
or
Deletion
How did the
mutation affect
the amino acid
sequence
(protein)?
(Circle one.)
No change
1 amino
acid
changed
Premature
stop signal
No stop
signal
1 amino acid
added/
deleted
All the amino acids
changed after the
point of mutation
pf3

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DNA Mutations Practice Worksheet

DIRECTIONS: Transcribe and translate the original DNA sequence. Then, do the same for each

mutated DNA sequence. Then, determine the consequence, if any, for each mutation, by

circling your choice for each question. You will need a Genetic Code Chart.

Original DNA

sequence:

TAC ACC TTG GCG ACG ACT

mRNA transcript:

amino acids:

Mutated DNA

sequence #1:

TAC ATC TTG GCG ACG ACT

mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation

Mutated DNA

sequence #2:

TAC GAC CTT GGC GAC GAC T

mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation

Mutated DNA

sequence #3:

TAC ACC TTA GCG ACG ACT

mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation

Mutated DNA

sequence #4:

TAC ACC TTG GCG ACT ACT

mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation

Mutated DNA

sequence #5:

TAC ACC TTG GGA CGA CT

mRNA transcript: (Circle any changes) amino acids: Type of mutation (Circle one.) Point ⇨ Substitution Frameshift ⇨ Insertion or Deletion How did the mutation affect the amino acid sequence (protein)? (Circle one.) No change 1 amino acid changed Premature stop signal No stop signal 1 amino acid added/ deleted All the amino acids changed after the point of mutation