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Drugs used in Migraine
Migraine
is unilateral
pulsatile
headache due^ to
dilation &^
inflammation of^ affected^
Cerebral Vessels^.
• Mild 4 Moderate Attacks - NSAIDs
Severe Attacks^ -
Ergot
alkaloids or -
trip
tans .
Ergot
Alkaloids :
Ergo
famine -^ Oral /
Sublingual
• Acts as Partial
agonist
at both ✗ and 5h
receptors
in Vasculature^ &
possibly
in CNS.
• Vaso constrictive^ Action ( to^ decrease^
pulsation
in
cerebral vessels^
during
migraine
attack )
Caffeine
enhances the
absorption of Ergot amine
and is a
powerful
vasoconstrictor .
Side
Effects
: Gastrointestinal distress . Nausea
vasoconstriction Ischemia
Abortion near term
trip
tans
Suma trip 1- (^) an (^) C subcutaneous^ )
choice
for (^) aborting Acute^
attacks
of Migraine .
- (^) Acts (^) as a selective agonist at 511T , (^) , (^) , (^) , ☐^ Receptors^ .
- Also suppresses (^) vomiting of^ Migraine . Frovatriptan - longest acting Rizatriptan -^ Fastest^ acting .
- All drugs
can cause
Coronary vaso spasm and (^) are
contraindicated in Ischemic^ heart^ disease^.
- Trip tans (^) are contraindicated (^) in Hypertension , Epilepsy ,
pregnancy
,^ liver^ &^ Renal^ impairment.
