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Material Safety Data Sheet
Ethyl acetate
ACC# 08750
Section 1 - Chemical Product and Company Identification
MSDS Name: Ethyl acetate Catalog Numbers: AC149470000, AC149470010, AC149470025, AC149470050, AC149470100, AC149470250, AC167810000, AC167810010, AC167810025, AC167815000, AC232110000, AC232110010, AC232110025, AC232110050, AC232110051, AC232110250, AC232110251, AC268350000, AC268350010, AC268350025, AC268350040, AC296790000, AC326610000, AC326610010, AC326610025, AC326900000, AC326901000, AC326902500, AC327880000, AC327880010, AC364240000, AC364350000, AC364350010, AC364350025, AC364351000, AC423170000, AC423175000, AC423680000, AC423680010, AC423680040, AC423685000, AC610060040, AC610170040, AC610341000, S75118, S80003, S80004, S93229, S93229A, S93230, S93230A, BP1125-1, BP1125-4, E124-20, E124-4, E124RS- 200, E124RS200, E145-1, E145-20, E145-200, E145-4, E145-500, E1454LC, E145FB115, E145FB19, E145FB200, E145FB50, E145POP-50, E145POP50, E145POPB-50, E145POPB50, E145RB-200, E145RB-50, E145RB115, E145RB19, E145RB200, E145RB50, E145RS-115, E145RS-50, E145RS115, E145RS28, E145RS50, E145S-4, E145SK-4, E145SS-200, E145SS115, E145SS1350, E145SS200, E145SS28, E145SS50, E189-4, E191-4, E195-1, E195-4, E195N1-19, E195N119, E195N2-19, E195N219, E195RS-200, E195RS115, E195RS200, E195RS50, E195SK-1, E195SK-4, E195SS-50, E195SS115, E195SS19, E195SS50, E196-4, E196-4LC, E196RS115, E196RS28, E196SK-4, E196SS-200, E196SS115, E196SS200, E196SS28, E196SS50, E1984LC, E95NB219, E95SS19, NC9173149, NC9234722, NC9406405, NC9728400, 23-005-51, 23-005- Synonyms: Acetic acid, ethyl ester; Acetic ether; Acetidin; Acetoxyethane; Ethyl acetic ester; Ethyl ethanoate; Vinegar naphtha. Company Identification: Fisher Scientific 1 Reagent Lane Fair Lawn, NJ 07410 For information, call: 201-796- Emergency Number: 201-796- For CHEMTREC assistance, call: 800-424- For International CHEMTREC assistance, call: 703-527-
Section 2 - Composition, Information on Ingredients
CAS# Chemical Name Percent EINECS/ELINCS 141 - 78 - 6 Ethyl acetate >99 205 - 500 - 4
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Appearance: clear, colorless liquid. Flash Point: -4 deg C.
Warning! Flammable liquid and vapor. Causes eye irritation. Breathing vapors may
cause drowsiness and dizziness. May cause respiratory tract irritation. Prolonged or repeated contact causes defatting of the skin with irritation, dryness, and cracking. Target Organs: Central nervous system, respiratory system, eyes, skin.
Potential Health Effects Eye: Causes eye irritation. Vapors may cause eye irritation. Skin: May cause skin irritation. Repeated or prolonged exposure may cause drying and cracking of the skin. The majority of human studies have demonstrated that ethyl acetate does not cause an allergic response on human skin. However, there is one case report of a woman developing a skin allergy to ethyl acetate. Ingestion: May cause irritation of the digestive tract. Ingestion of large amounts may cause central nervous depression. May cause headache, nausea, fatigue, and dizziness. These effects may be caused in part by ethanol which is released when ethyl acetate is broken down in the body. Inhalation: May cause respiratory tract irritation. Inhalation of high concentrations may cause narcotic effects. May be harmful if inhaled. Chronic: Chronic inhalation may cause effects similar to those of acute inhalation. Animals exposed to 4300 ppm (mice) and 2000 ppm (guinea pig), 6 hours/day for 7 days developed minor blood changes & loss of appetite. There was no indication of liver or kidney injury. Rabbits exposed to 16000 mg/m3 (4440 ppm), 1 hour/day for 40 days developed secondary anemia (decreased number of red blood cells), decreased hemoglobin levels, increased numbers of macrophages, congestion and fatty degeneration of various organs, and enlargement of the spleen. A reviewer suggested that the organ damage may have been due to impurities present in the ethyl
Section 4 - First Aid Measures
Eyes: In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Get medical aid. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively.
Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels. Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Ethyl acetate 400 ppm TWA
400 ppm TWA; 1400 mg/m3 TWA 2000 ppm IDLH
400 ppm TWA; 1400 mg/m3 TWA
OSHA Vacated PELs: Ethyl acetate: 400 ppm TWA; 1400 mg/m3 TWA Personal Protective Equipment Eyes: Wear chemical splash goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Liquid Appearance: clear, colorless Odor: sweet, fruity odor pH: Not available. Vapor Pressure: 73 mm Hg @ 20 deg C Vapor Density: 3.04 (Air=1) Evaporation Rate: 6.2 (Butyl acetate=1) Viscosity: 0.44 cps @ 25 deg C Boiling Point: 77 deg C Freezing/Melting Point: -83 deg C Decomposition Temperature: Not available. Solubility: Slightly soluble. Specific Gravity/Density: 0.9 (Water=1) Molecular Formula: C4H8O Molecular Weight: 88.
Section 10 - Stability and Reactivity
Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Ignition sources, moisture, excess heat, attacks some plastics,
rubber, and coatings, confined spaces. Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, strong bases. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, ethyl alcohol, acetic acid. Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
RTECS#:
CAS# 141-78-6: AH
LD50/LC50:
CAS# 141-78-6:
Inhalation, mouse: LC50 = 45 gm/m3/2H; Inhalation, rat: LC50 = 200 gm/m3; Oral, mouse: LD50 = 4100 mg/kg; Oral, rabbit: LD50 = 4935 mg/kg; Oral, rat: LD50 = 5620 mg/kg; Skin, rabbit: LD50 = >20 mL/kg; .
Carcinogenicity: CAS# 141-78-6: Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No information available. Teratogenicity: No information available. Reproductive Effects: No information available. Mutagenicity: Cytogenetic Analysis: hamster fibroblast 9g/L Sex Chromosome Loss/Non- disjunction: S. cerevisiae 24400 ppm. Neurotoxicity: No information available. Other Studies:
Section 12 - Ecological Information
Ecotoxicity: Fish: Fathead Minnow: 230mg/L; 96H; Daphnid LC50=2500 mg/L/96H Golden orfe LC50=270 mg/L/48H Environmental: Terrestrial: Expected to have high mobility in soil. Volatilization of ethyl acetate from moist soil surfaces is expected to be important. Aquatic: Not expected to adsorb to suspended solids and sediment in water. Atmospheric: Expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 10 days. Physical: Substance biodegrades at a high rate with little bioconcentration. Other: No information available.
This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# 141-78-6 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
California Prop 65
California No Significant Risk Level: None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives Hazard Symbols: XI F Risk Phrases: R 11 Highly flammable. R 36 Irritating to eyes. R 66 Repeated exposure may cause skin dryness or cracking. R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases: S 16 Keep away from sources of ignition - No smoking. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 33 Take precautionary measures against static discharges.
WGK (Water Danger/Protection) CAS# 141-78-6: 1 Canada - DSL/NDSL CAS# 141-78-6 is listed on Canada's DSL List. Canada - WHMIS This product has a WHMIS classification of B2. This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations. Canadian Ingredient Disclosure List CAS# 141-78-6 is listed on the Canadian Ingredient Disclosure List.
Section 16 - Additional Information
MSDS Creation Date: 12/12/ Revision #10 Date: 6/29/
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.
