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Red Blood Cells
4.2-6 cells/ulnon-nucleated biconcave diskhemoglobin facilitates O2 transport to tissueslive 90-120 daysbreak down in spleen; iron and amino acids are recycledheme molecule converts to bilirubin and iron TERM 2
What does RBC production regulation require?
DEFINITION 2 ErythropoietinIronVitamin B12folate TERM 3
Regulation of RBC
DEFINITION 3 controlled by cytokineshematopoietic growth factorserythropoietin TERM 4
Cytokines
DEFINITION 4 protein messengers that regulate blood cell precursor functionaid in regulation of RBC TERM 5
Erythropoiesis
DEFINITION 5 production of red blood cellsnormoblasts get ridof nucleus and organelles
Reticulocytes
immature red blood cellsmature within blood stream or in spleenbecome adult erythrocytes TERM 7
Bilirubin Cycle
DEFINITION 7 aged red blood cells are broken down by macrophages in spleenhemoglobin broken down into heme and globinglobin forms amino acids (reused)heme releases free/unconjugated bilirubin-->transported to liver as free bilirubin-->becomes conjugated and can be excreted in bile, then feces and urineheme releases recyclable iron TERM 8
Anemias
DEFINITION 8 low number circulating red blood cells or hemoglobin or both that impairs oxygen carrying-Hct-Hgb-RBC indices: size, amount hemoglobin in RBC can indicate type of anemiaCauses: decrease # RBC production, blood loss; decrease HGB content; abnormal HGB (hemolysis) TERM 9
Iron-deficiency anemia
DEFINITION 9 most common anemia (microcytic hypochromic anemia)deficiency in iron to make hemoglobin resulting in defect in oxygen carrying capacitydecrease in dietary iron intakedecrease absorption (in duodenum)blood lossincrease bodily demands TERM 10
Clinical Manifestations of Iron-deficiancy
anemia
DEFINITION 10 cyanosis (blue tinted)epithelial atrophybrittle; spoon-shaped nailspicadelayed healing
