Docsity
Docsity

Prepare for your exams
Prepare for your exams

Study with the several resources on Docsity


Earn points to download
Earn points to download

Earn points by helping other students or get them with a premium plan


Guidelines and tips
Guidelines and tips

exam 3 | BIOL 311 - Principles Of Cell Biol (DIS), Quizzes of Biology

Class: BIOL 311 - Principles Of Cell Biol (DIS); Subject: Biology; University: SUNY at Binghamton; Term: Spring 2011;

Typology: Quizzes

2010/2011

Uploaded on 04/12/2011

crfrink09
crfrink09 🇺🇸

5

(1)

8 documents

1 / 5

Toggle sidebar

This page cannot be seen from the preview

Don't miss anything!

bg1
TERM 1
co-translational targeting
DEFINITION 1
when cells begin to import most proteins into the ER before
synthesis is completeribsosome synthesizing the protein is
attached directly to the ER membrane, enabling one end of
the protein to be translocated into the ER while the rest of
the polypeptide chain is being assembled. These ribosomes
coat the ER thus creating the RER.
TERM 2
post-translational
DEFINITION 2
synthesis and transport are two separate processes
TERM 3
signal recognition particle (SRP)
DEFINITION 3
cycles between the ER membrane and cytosol and binds to
the signal sequence and the SRP receptor
TERM 4
stop transfer sequence
DEFINITION 4
anchors the protein in the membrane after the ER signal
sequence has been released from the trans-locator and has
been cleaved off
TERM 5
type 1 proteins
DEFINITION 5
hydrophobic stop transfer sequencesignal sequence is
cleaved off
pf3
pf4
pf5

Partial preview of the text

Download exam 3 | BIOL 311 - Principles Of Cell Biol (DIS) and more Quizzes Biology in PDF only on Docsity!

co-translational targeting

when cells begin to import most proteins into the ER before synthesis is completeribsosome synthesizing the protein is attached directly to the ER membrane, enabling one end of the protein to be translocated into the ER while the rest of the polypeptide chain is being assembled. These ribosomes coat the ER thus creating the RER. TERM 2

post-translational

DEFINITION 2 synthesis and transport are two separate processes TERM 3

signal recognition particle (SRP)

DEFINITION 3 cycles between the ER membrane and cytosol and binds to the signal sequence and the SRP receptor TERM 4

stop transfer sequence

DEFINITION 4 anchors the protein in the membrane after the ER signal sequence has been released from the trans-locator and has been cleaved off TERM 5

type 1 proteins

DEFINITION 5 hydrophobic stop transfer sequencesignal sequence is cleaved off

type 2 proteins

no signal sequence is cleaved from amino endremains attached to the anchor sequence: signal anchor sequencecarboxylic end in ER lumen, amino end remains in the cytosoltranslocon stays open TERM 7

type 3 proteins

DEFINITION 7 no signal sequence is cleaved from amino endremains attached to the anchor sequence: signal anchor sequenceamino end ends in the ER lumen, carboxylic end in the cytosol TERM 8

type 4 proteins

DEFINITION 8 multi pass proteinsno signal sequence on the amino endhave signal anchor sequence and stop-transfer signal TERM 9

lipid anchor proteins

DEFINITION 9 signal is cleaved on amino endhydrophobic stop-transfer sequenceA GPI transamidase cleaves protein and link it to a GPI anchor in the ER membrane TERM 10

glycosylation

DEFINITION 10 Always driven by an enzyme2 types:Addition of CHO chains to Amide nitrogen of asparagine N-linked glycosylationOH of serine and threonine O-linked glycosylation

calnexin

Membrane bound chaperone protein, only functions by binding to glucose on carbohydrate protein(aka lectin) TERM 17

Bip

DEFINITION 17 chaperone protein that keeps protein linear, binds to amino acid, requires ATP TERM 18

KDEL

DEFINITION 18 signal retrieval sequence, and must bind to its receptor to return back to the ER The pH difference between ER and Golgi tightens the binding of KDEL proteins to receptor to avoid their escape. TERM 19

constitutive pathway

DEFINITION 19 proteins secreted outside the cell as soon as they're formed: Maintenance proteins (ECM proteins) TERM 20

regulated pathway

DEFINITION 20 Proteins are synthesized and stored until needed (hormones)

m6p enzyme tag

in the trans-golgi, where m6p receptors reside. -require a low pH level to work -act in digesting material sent to the lysosomes -when some molecules escape, they are taken back by receptor-mediated endocytosis to the lysosomes TERM 22

i- cell disease

DEFINITION 22 m6p enzyme tag is defective and therefore the cell cannot be taken to the lysosome for digestion, this leads to the build up of cell toxicity -hydrolases cannot go to the lysosome TERM 23

Hurler's disease

DEFINITION 23 enzyme required for the breakdown of certain types of glycosaminoglycan chains is defective or missing -> mental retardation, organ failure TERM 24

Hsc

DEFINITION 24 escorts mitochondrial proteins, keeps them unfolded chaperone protein uses ATP