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Typology: Assignments
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Causative Agent
Common Name “Infectious” “Serum” “Post- Transfusion” “Delta” “Enteric” Transmissio n Route Fecal-Oral (Enteral) Travelers to Foreign Countries Parenteral Sexual Perinatal Parenteral Sexual Parenteral Sexual Perinatal Can only be present w/HBV Fecal-Oral (Enteral) Age Most Affected Children Any Adults 1945- birth yrs. have higher incidence Any Young Adults Onset Abrupt Insidious Abrupt However pt’s can be asymptomatic for 15-20 yrs. before s/s Abrupt Abrupt Incubation Period
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days Carrier State N/A Yes Yes N/A N/A Severity Mild Can be Severe, especially in kids <5yrs Typically sub- clinical Infection with HBV often severe Mild for most However Severe for Pregnant pt’s Disease Progression 50-70% show symptoms Abrupt onset w/flu-like symptoms Self-limiting Different depending on age and comorbidities Typically asymptomatic Chronic s/s’s include liver cirrhosis and CA Different depending on age group Can range from asymptomatic carrier state to 50-70% show s/s’s Pregnant Pt’s: Severe S/S’s, including miscarriage
acute liver failure Chronic ?? No Yes (up to 10%, w/kids having more chronicity) Yes (in 80%) Yes No Clinical Outcomes w/Chronic Inf. N/A Cirrhosis or Hepatocellular Carcinoma Cirrhosis or Hepatocellular Carcinoma Co-Infection with HBV
Prevention IgG Pre & Post Exposure Vaccine Once you have HAV you are immune HBIG for Post Exposure Hep B Vaccine Blood donor screening since 1992 HBV Vaccine Ensure safe drinking water Cure? No TX symptoms No TX w/Interferon with varying success rates No TX w/Interferon with varying success rates No TX with Interferon for 12 months w/low success rates No TX symptoms Prognosis Excellent Worse with age & co-morbidities Moderate, depends on what damage has occurred Acute = Good Chronic = Poor Good