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Final Exam | BIO 012 - GENERAL/PRE-PROFESSIONAL BIO I, Quizzes of Biology

Class: BIO 012 - GENERAL/PRE-PROFESSIONAL BIO I; Subject: Biology; University: Drake University; Term: Fall 2014;

Typology: Quizzes

2013/2014

Uploaded on 12/07/2014

kayla227
kayla227 🇺🇸

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TERM 1
What are 2 ways to reshape a genome?
DEFINITION 1
- change the chromosomal number- Change the arrangement
of DNA: move it around
TERM 2
How do chromosome get changed?
DEFINITION 2
IDITR-insertions: small insertions; may effect one gene; large can cause
overexpression; duplication; tandem and non tandem >>overesxpression can
cause more protein encoded-deletions- depe nds if gene is even expressed; small
may effect single gene; large can result loss in multiple gene-inversions:
nucleotides do a 180; ina single gene can c hange codon sequence; can introduce
start and stop codons>>change encoded am ino acid-translocation; movement of
material between two chromsomes; recipric ol: regions are exchanged;
nonrecipricol: region from one is moved to a nother-recombination: crossing over
of chromatids causing exchange of genetic m aterial>>homologous**depend on
size and location of changes
TERM 3
Modern Genetics: Fruit
Flies
DEFINITION 3
- drosophila-eye color-mendelian mating-controlled
breeding>>8 chromosomes; 3 autosomes and one sex-short
generation time-large number of babies-pure breds-wt=wild
type normal red-mutant- white-wild type not always
dominant to mutant
TERM 4
Mendels laws
DEFINITION 4
-law of segregation- violated in x linked traits in males-
hemizygous- genotype=phenotype-law of law independent
assortment
TERM 5
Parental Type
DEFINITION 5
-same as the parent
pf3
pf4
pf5
pf8
pf9
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What are 2 ways to reshape a genome?

- change the chromosomal number- Change the arrangement

of DNA: move it around

TERM 2

How do chromosome get changed?

DEFINITION 2

IDITR-insertions: small insertions; may effect one gene; large can cause overexpression; duplication; tandem and nontandem >>overesxpression can cause more protein encoded-deletions- depends if gene is even expressed; small may effect single gene; large can result loss in multiple gene-inversions: nucleotides do a 180; ina single gene can change codon sequence; can introduce start and stop codons>>change encoded amino acid-translocation; movement of material between two chromsomes; recipricol: regions are exchanged; nonrecipricol: region from one is moved to another-recombination: crossing over of chromatids causing exchange of genetic material>>homologous**depend on size and location of changes TERM 3

Modern Genetics: Fruit

Flies

DEFINITION 3

- drosophila-eye color-mendelian mating-controlled

breeding>>8 chromosomes; 3 autosomes and one sex-short

generation time-large number of babies-pure breds-wt=wild

type normal red-mutant- white-wild type not always

dominant to mutant

TERM 4

Mendels laws

DEFINITION 4

-law of segregation- violated in x linked traits in males-

hemizygous- genotype=phenotype-law of law independent

assortment

TERM 5

Parental Type

DEFINITION 5

-same as the parent

recombinant

- recombination has occured- different than parental type

TERM 7

Linked Genes

DEFINITION 7

-parentals>recombinantsRF < 50%genes are on the same

chromsome

TERM 8

Unlinked genes

DEFINITION 8

-parentals=recominants-RF=50%-genes on separate

chromosomes-independent assortment

TERM 9

RF

DEFINITION 9

-recombination frequency-farther away= more frequent

TERM 10

Complicated Genetics

DEFINITION 10

-GIE-Genetic imprinting: gene only expressed on one of the

chromosome>>mom or dad inherited-Epigenetics: utilization

of differtn methylation patterns in dnautilization of diff

methyl and acey patterns on dna proteins

Nitrogenous Bases

-adenine adn guanine are purines-cytosine adn thymine are

pyrimidines

TERM 17

Nucleotide>Nucleic acid

DEFINITION 17

5'>3'phosphate to alcohol

TERM 18

elongation

DEFINITION 18

-more nucleotides-requires energy-2 phosphates-DNA

dependent DNA polymerase

TERM 19

What is a chromosome made of?

DEFINITION 19

DNA

TERM 20

DNA

DEFINITION 20

- strands held together by hydrogen bonds- weak but alot of

them-A and T have 2 hydrogen bonds-G and C have 3

Genome

-total genetic information (DNA) in a cell-genome made of

alot of genesProkaryotic: single closed circular DNAsmall adn

efficientclosed =no ends=agelesshaploid-Eukaryoticlarger,

linear DNA moleculesends-

telomeres>>shortening=agingJunk dnadiploid

TERM 22

Necessary Functions of DNA

DEFINITION 22

- replication1. partially decompress DNA>Chromatin =

DNA+proteins-prokaryotes- not as compressed-no histones-euk-

dna wraps around to fit in nucleus2. unwind double helix-helicase-

bresak hydrogen bonds3. Read old DNA (3' to 5' adn make new

dna 5' to 3')-requires primer - serve as template for transcription:

RNA synthesis- central dogma-transcription to translation-

DNA>RNA>PROTEIN

TERM 23

semi conservative

DEFINITION 23

-each new cell contains one old and one new starnd-helcase

unwinds DNA strands-each strand used as template for

replication

TERM 24

Accuracy

DEFINITION 24

-proofreading-repair mechanisms

TERM 25

DNA vs RNA

DEFINITION 25

RNA: uracil instead of thymineDNA DOUBLE STRANDEDRNA

SINGLE STRANDEDpolymerases-DNA requires primer vs RNA

can work de novo-LengthDNA lasts life of cell vs RNA 10

hours#DNA 1 vs RNA more than 1copies of productDNA 1

RNA more than 1

Ribosomes

-translate mRNA to protein-more than one can be attached to

mRNA thus more proteins can come from teh same strand of

mRNA

TERM 32

stop codons

DEFINITION 32

-causes

TERM 33

R group

DEFINITION 33

-different for each amino acid-determines amino acid

properties

TERM 34

amino acid>protein

DEFINITION 34

- positive change in energy so endothermic-condensation

reaction

TERM 35

Types of Mutations

DEFINITION 35

-SID-mutation: changein nucleic acid sequence1.

Substitutions-silent: codes for same amino acid-coding-

changes and codes for different amino acid (missense) or

stop codon (nonsense)>>codon to stop codon=premature

termination in translation2. Insertions/ deletions-in

frame:uses same ORF-out of frame- opens different ORF

Point Substitution

-Change @ DNA level seen at RNA level but nut at the protein

because its the same amino acid

TERM 37

Amino Acid Changes

DEFINITION 37

-conservative: change to similar amino acid- similar r group-

similar properties-non conservative: amino acid of diff type

ex. polar- nonpolar

TERM 38

Types of mutations

DEFINITION 38

-natural:UV, xrays, oxidation-chemical-both random

TERM 39

Protein

DEFINITION 39

-variable, constantly being produced and degraded

TERM 40

Types of Genes

DEFINITION 40

Constitutive: always onInducible: turn on and off-basal level:

metabolic (homeostasis)-up regulation:increased levels of

mRNA-down: decreased

Enhancers

enhance transcription levelssome turn off or decrease

levelscannot be near the gene must be up or down stream

TERM 47

chromosomal structure

DEFINITION 47

-centromere and telomeres= dead zones-DNA must be

DEcompressed-Tight binding to histones doesnt allow

tanscription

TERM 48

What does a virus consist of?

DEFINITION 48

- nucleic acid-protein>one to protect>one to deliver-

enveloped need both-non enveloped has one protein for both

TERM 49

Virus Life Cycle

DEFINITION 49

  1. Attachment-specific process-recognizes proteins or molecules on surface of cell-virus utilizes what is already there-must match2. Entry-fusion- endoctosispentration and uncoating3. Nucleic Acid Replication-DNA>DNA -normal same processRNA form RNA-non cellular enzyme capable so virus provides polymeraseRDRP are error prone but must follow same process-Retros-translation same utilizes ribosomes4. Translation5. Assembly-icosahedral: series of pentagrams, repeats proteins to generate a shell to protect and deliver nucleic acid-Helical: coat protein over nucleic acid to protect nucleic acid6. Release-lytic: destroys cell-budding: plasma membrane7.Maturation-non to infectious, enzymatic process, intra or extra cellular TERM 50

Baltimore Classification

DEFINITION 50

DNA Genome-single ab-souble goodRNA genome-single

norm-double ab

Infections (animals)

Acute>infectionChronic>continual replication:

hepatitis>latent:hereps>integration: retroviruses

TERM 52

Beneficial Uses for Viruses

DEFINITION 52

-gene therapy-disease prevention-nanotechnology

TERM 53

Less than a virus

DEFINITION 53

-Viroids and prions