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Final Examination Practice Questions - Molecular Genetics | BI 381, Exams of Molecular biology

Southeast Missouri State University (SEMO)Molecular biology
Prof. Allen C. Gathman

Material Type: Exam; Professor: Gathman; Class: Molecular Genetics; Subject: Biology; University: Southeast Missouri State University; Term: Fall 2008;

Typology: Exams

Pre 2010

Uploaded on 08/08/2009

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koofers-user-tzs 🇺🇸

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BI 381 Fall 2008
Final Exam
Relax.
Write your name on the back of the last page only.
1. a. (15 points) Complete this diagram by filling in the rest of this two base-pair DNA molecule.
Show covalent bonds as lines, hydrogen bonds as dotted lines, double bonds as double lines,
carbons in a ring as corners, and other atoms as their atomic symbols. You need not show
hydrogens unless they are part of hydrogen bonds or have some other functional significance.
pf3
pf4
pf5

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Download Final Examination Practice Questions - Molecular Genetics | BI 381 and more Exams Molecular biology in PDF only on Docsity!

BI 381 Fall 2008

Final Exam Relax. Write your name on the back of the last page only.

  1. a. (15 points) Complete this diagram by filling in the rest of this two base-pair DNA molecule. Show covalent bonds as lines, hydrogen bonds as dotted lines, double bonds as double lines, carbons in a ring as corners, and other atoms as their atomic symbols. You need not show hydrogens unless they are part of hydrogen bonds or have some other functional significance.
  1. a. (10 points) Guo and Birchler tested the hypothesis that a structural gene is expressed in proportion to the number of copies of that gene present. In their experiment, they used partial trisomics and measured the amount of specific mRNAs that they produced, using a Northern blot. They also measured the amount of rRNA present in each lane on the blot. Explain why they measured rRNA amounts in these experiments and what they did with these measurements. b. (10 points) According to the CONCLUSIONS of Guo and Birchler's paper, why do trisomic individuals show phenotypic abnormalities?
  1. Consider the following anabolic pathway in yeast: Notes: Compounds F and D are combined by condensation to form G; compounds H and G are combined by condensation to form I. Compound B is split by hydrolysis to form compounds E and F. The organism must either make or receive compound I in order to grow. Each mutant is mutant for only one gene (coding for one enzyme). a. (16 points) In the table below, indicate whether each mutant organism will be able to grow when placed on each medium by putting + for growth of the organism and - for no growth of the organism. Please make them clear so I can read them. Growth on Minimal Medium Supplemented with Compound: Mutan t (None )

A B C D E F G H I

b. (5 points) Suppose you crossed two of these mutants, numbers 2 and 6, to get a diploid yeast strain. This strain would contain all the genes found in either of the two parents, and would produce all the active enzymes that either of the two parents produces. Assume all reactions are substrate limited, so that one “dose” of enzyme is enough to convert all available substrate into product(s). Would this strain grow on minimal medium? Explain.

  1. Consider the gene shown below.

    intron1 intron _GRE____/ /_GC box______TATA|_exon1 XXXXX exon2 XXXXX_____ (-50kb) -100 - a. (15 points) Describe the sequence of events in the formation of the preinitiation complex for this gene, assuming all relevant activator proteins are available and functioning properly. Include all the components of the complex up to the binding of RNA Pol II. b. (5 points) What will TFIIH do after RNA Pol II binds, and what’s the significance of this activity?

Binding Site Consensus Trans-acting Protein Tata Box TATAA TBP Cat Box GCAAT CTF GC Box GGGCGG SP Octamer ATTTGCAT Oct-1, Oct- kB GGGACTTTCC NFkB