TERM 1
Mechanism of Action
DEFINITION 1
Block DNA synthesis by inhibiting bacterial topoisomerase II
(DNA gyrase) and topoisomerase IV. Inhibition results
in,topoisomerase II prevents relaxation of supercoiled
DNAtopoisomerase IV prevents separation of replicated DNA
TERM 2
Activity
DEFINITION 2
good for gram pos and gram neg MRSA often resistant Most
active agent against gram neg, Pseudomonas aeruginosa is
cipro
TERM 3
Resistance
DEFINITION 3
occurs through point mutations in the binding site on the
target enzyme resistance can occur through altered
permeability
TERM 4
Pharmacokinetics
DEFINITION 4
cations block absorption (antacids) dose adjustment required
for CC less than 50 mL/min except for moxifloxacin
TERM 5
Clinical Uses
DEFINITION 5
urinary tract infections bacterial diarrhea (shigella,
salmonella, toxigenic E coli, campylobacter) bone and joint
infections (except norfloxacin) cipro is drug of choice for
anthrax levo, gati and gemifloxacin used for respiratory
infections
