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Drug Profile: Furosemide - Mechanism of Action, Indications, Dosage, and Adverse Reactions, Lecture notes of Medical statistics

Belmont CollegeMedical statistics

A detailed profile of the drug furosemide, including its generic and brand names, mechanism of action, indications and field use, contraindications, adverse reactions, notes on administration, incompatibilities and drug interactions, adult and pediatric dosage, routes of administration, onset and peak effects, duration of action, and dosage forms and packaging. It also includes special notes about ototoxicity and allergic reactions.

What you will learn

  • What are the indications for using Furosemide?
  • What are the contraindications for using Furosemide?
  • What is the mechanism of action of Furosemide?

Typology: Lecture notes

2021/2022

Uploaded on 09/12/2022

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GD-041-PHS-EMS: Drug Profile for Furosemide
Page 1 of 2 5/15/03
GENERIC NAME: FUROSEMIDE
112.13
BRAND NAME: Lasix
CLASS: loop diuretic
Mechanism of Action:
Pharmacologic: Inhibits electrolyte reabsorption in the ascending Loop of Henle. Promotes
excretion of sodium, potassium, chloride. Vasodilation increases venous capacitance and
decreases afterload.
Clinical: Diuresis
Indications and Field Use:
Pulmonary edema; congestive heart failure
Contraindications:
Anuria (relative)
Hypovolemia
Hypotension
Adverse Reactions:
May exacerbate hypovolemia
Hyperglycemia (due to hemoconcentration)
Hypokalemia
May decrease the response to pressors
NOTES ON ADMINISTRATION
Incompatibilities/Drug Interactions:
Increased effects with other antihypertensives
Adult Dosage:
On oral furosemide therapy: Consider initial dose of 2 times daily oral dose, if no effect in 20
minutes may double initial dose.
Not on oral furosemide therapy: 0.5-1 mg/kg to a maximum of 2 mg/kg (usually 20-40 mg) IV
slowly.
Pediatric Dosage:
1 mg/kg IV slowly
pf2

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Download Drug Profile: Furosemide - Mechanism of Action, Indications, Dosage, and Adverse Reactions and more Lecture notes Medical statistics in PDF only on Docsity!

GD-041-PHS-EMS: Drug Profile for Furosemide

Page 1 of 2 5/15/

GENERIC NAME: FUROSEMIDE

BRAND NAME: Lasix

CLASS: loop diuretic

Mechanism of Action:

Pharmacologic: Inhibits electrolyte reabsorption in the ascending Loop of Henle. Promotes excretion of sodium, potassium, chloride. Vasodilation increases venous capacitance and decreases afterload. Clinical: Diuresis

Indications and Field Use:

Pulmonary edema; congestive heart failure

Contraindications:

Anuria (relative) Hypovolemia Hypotension

Adverse Reactions:

May exacerbate hypovolemia Hyperglycemia (due to hemoconcentration) Hypokalemia May decrease the response to pressors

NOTES ON ADMINISTRATION

Incompatibilities/Drug Interactions:

Increased effects with other antihypertensives

Adult Dosage:

On oral furosemide therapy: Consider initial dose of 2 times daily oral dose, if no effect in 20 minutes may double initial dose. Not on oral furosemide therapy: 0.5-1 mg/kg to a maximum of 2 mg/kg (usually 20-40 mg) IV slowly.

Pediatric Dosage:

1 mg/kg IV slowly

GD-041-PHS-EMS: Drug Profile for Furosemide

Page 2 of 2 5/15/

Routes of Administration:

Slow IV push

Onset of Action:

5 minutes (vasodilation)

Peak Effects:

20-60 minutes (diuresis)

Duration of Action:

Variable

Dosage Forms/Packaging:

20 mg/2 mL ampule, vial, syringe 40 mg/4 mL ampule, vial, syringe 100 mg/10 mL ampule, vial, syringe

Arizona Drug Box Supply Range:

PARAMEDIC: 4 (20 mg/2 mL) or 4 (40mg/4mL) or 2 (100mg/10mL)

INTERMEDIATE: 4 (20 mg/2 mL) or 4 (40mg/4mL) or 2 (100mg/10mL)

Special Notes:

Ototoxicity and resulting deafness can occur. Since furosemide is a sulfonamide derivative, it may induce allergic reactions in patients with sensitivity to sulfonamides (sulfa drugs).