

Study with the several resources on Docsity
Earn points by helping other students or get them with a premium plan
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
Community
Ask the community for help and clear up your study doubts
Discover the best universities in your country according to Docsity users
Free resources
Download our free guides on studying techniques, anxiety management strategies, and thesis advice from Docsity tutors
A comprehensive drug profile for diltiazem, a calcium channel blocker used to manage rapid ventricular rates associated with atrial fibrillation and atrial flutter. The mechanism of action, indications and contraindications, dosage information for adults and pediatrics, onset and duration of action, and potential adverse reactions. It also includes notes on administration, incompatibilities, and drug interactions.
What you will learn
Typology: Slides
1 / 3
This page cannot be seen from the preview
Don't miss anything!
BRAND NAME: Cardizem CLASS: Calcium Channel Blocker Calcium antagonist
Mechanism of Action:
Pharmacological: Inhibits calcium ion influx across cell membranes during cardiac depolarization, decreases SA and AV conduction and dilates coronary and peripheral arteries and arterioles. Clinical effects: Slows the rapid ventricular rate associated with atrial fibrillation and atrial flutter, and reduces coronary and peripheral vascular resistance.
Indications and Field Use:
Rapid ventricular rates associated with atrial fibrillation and atrial flutter, and for PSVT refractory to adenosine.
Contraindications:
Hypotension (less than 90 mmHg systolic) Acute Myocardial infarction Cardiogenic shock Ventricular tachycardia or wide-complex VT of unknown origin Second or third-degree AV block Wolff-Parkinson-White (WPW) syndrome Sick Sinus syndrome Beta Blocker Use
Adverse Reactions:
CV: hypotension, bradycardia, heart block, chest pain, and asystole GI: nausea and vomiting CNS: headache, fatigue, drowsiness
NOTES ON ADMINISTRATION
Incompatibilities/Drug Interactions:
Avoid use in patients with poison- or drug-induced tachycardia. Calcium chloride can be used to prevent the hypotensive effects of this drug and treat patients with a calcium channel blocker overdose. Beta blocker use
Adult Dosage:
Initial: 0.25 mg/kg IVP (usually 20 mg) administered over 2 minutes
If response is inadequate, repeat in 15 minutes: 0.35 mg/kg IVP administered over 2 minutes Maintenance infusion: 5.0 to 15 mg/hr
Pediatric Dosage:
The safety and efficacy of this drug for use in children has not been established.
Route of Administration:
Intravenous bolus(es) followed by a maintenance infusion
Continuous infusion for maintenance Standard solution: Dilute 100mg (20 ml) in NS 80ml (1 mg/ml) Dosage: 5 to 10 mg/hr initially; may be adjusted to 15mg/hr if needed
Onset of Action:
IV - immediately
Peak Effects:
IV - 2 hours or less
Duration of Action:
IV - 4 to 6 hours
Dosage Forms/Packaging:
Injection - 5.0 mg/ml 5.0 ml and 10 ml vials Powdered Form-25 mg vial, (2)