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Information on the diagnosis and management of Nursing Home Acquired Pneumonia (NHAP), including definitions, issues, goals, prevention, diagnosis, and background. It covers topics such as exclusions, definitions, symptoms, diagnosis criteria, prevention methods, and treatment options. The guideline is administered by the Alberta Medical Association.
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This clinical practice guideline (CPG) was developed by an Alberta CPG Working Group.
♦ Hospital acquired pneumonia (onset within 14 days of discharge from an acute care facility) ♦ Aspiration pneumonia (see Appendix 1) ♦ Patients with cystic fibrosis, tuberculosis, or bronchiectasis
♦ Pneumonia in a patient residing in a nursing home* _ This applies to any congrgate residential setting for older and disabled patients that have high personal and professional care needs. These are sometimes known as long term care facilities, auxiliary hospitals, chronic care centres, or continuing care centres._*
♦ Treatment for NHAP should take into account the individual’s personal directives ♦ There is a lack of well designed studies in this patient population ♦ Chest radiography is not widely available or practical in many locations ♦ Microbiologic diagnosis of NHAP has significant limitations and as such, treatment of NHAP is usually empiric ♦ Delay in administration of antibiotics for the empiric treatment of NHAP may lead to in- creased patient morbidity and mortality ♦ Inappropriate use of antibiotics may adversely affect patient outcomes and may increase anti- microbial resistance
Administered by the Alberta Medical Association
♦ To enhance an earlier detection and treatment of NHAP ♦ To increase the accuracy of the clinical diagnosis of NHAP ♦ To optimise the appropriate use of laboratory and diagnostic imaging services ♦ To optimise the use of antibiotics in the treatment of NHAP ♦ To foster teamwork in the evaluation and manage- ment of patients with NHAP ♦ To optimise the decision for patient transfer to hospital ♦ To improve patient outcomes through decreased morbidity and mortality.
♦ Limit the spread of infections (e.g., hand washing and attention to outbreak management guidelines) ♦ Influenza and pneumococcal vaccines are recom- mended (see Appendix 2) ♦ Smoking cessation and avoidance of environ- mental tobacco smoke
Although a new infiltrate seen on chest X-ray with compatible clinical signs is the gold standard for the diagnosis of NHAP, in nursing home settings the diagnosis must often be made on clinical grounds alone. The physical examination must include blood pressure, heart rate, respiratory rate and auscultation of the respiratory system. The above recommendations are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. They should be used as an adjunct to sound clinical decision making.
Symptoms & Signs Cluster If chest X-ray is not available, tachypnea and at least 1 of the following signs and symptoms should be present to make a diagnosis of probable NHAP ♦ Ideally the diagnosis of pneumonia should be sup- ported with chest X-ray, oxygen saturation, complete blood count and differential, blood cultures, and spu- tum cultures. As these tests are frequently unavailable in the nursing home setting, refer to management below. Note: There is still value in performing these tests even after treatment has been initiated. MANAGEMENT Assessment ♦ Determine the degree of medical treatment desired by the patient or legal decision maker such as a guardian or agent named in an enacted personal directive. ♦ Review vital signs
BACKGrOUND Introduction Nursing home-acquired pneumonia (NHAP) is defined as pneumonia occurring in a resident of a Long Term Care (LTC) facility. Prevalence ranges between 1.1 to 2.5% in chronic care facilities^1 , has an incidence of 13 - 48% of all LTC infections and is a common cause for transfer to hos- pital.^2 Lower respiratory tract infections and pneumonia are very common infectious disorders in LTC facilities.^3 In one region 8% of all transfers to hospital were diagnosed in the emergency department with pneumonia, 20% of whom were transferred back to LTC for further treatment.^4 NHAP mortality may be as high as 44%.^5 Higher mortality rates ( two to threefold) distinguishes NHAP from CAP. NHAP was first described in 1978.^6 Since then there has been much written regarding NHAP and its management but there has been a lack of well-designed studies in this patient population.^7 In the absence of randomized controlled trial data for empiric drug therapy, many clinicians have extrapolated findings from community acquired pneumonia (CAP) clinical pathways and guidelines.^8 There is little, if any, evidence to support the application of CAP guide- lines to nursing homes primarily due to advanced patient age and disease complexity in the risk stratification proc- ess. Recent work by Loeb and colleagues in Ontario have demonstrated that the use of a clincal pathway reduced the number of transfers to hospital and had comparable clinical outcomes to a ‘usual’ treatment group.^9 LTC is a unique health care delivery setting with many, often complex, considerations when it comes to clinical decision-making. There are few guidelines that exist to assist physicians in prescribing for LTC patients.^10 The following key elements impact the assessment and man- agement of NHAP in this setting. risk Factors Nursing home patients have lower levels of functioning, are at an advanced age and have significant co-morbid conditions, e.g., COPD, dementia and atherosclerotic heart disease. Other risk factors identified for death from nursing home acquired pneumonia include aspiration, bed-fast state, cerebrovascular accident, difficulty with oropharyngeal secreations, dysphagia, feeding tube, frailty, incontinence, and sedative hypnotic use. Decision-making The high prevalence of dementing illness in LTC is a further limitation on good and reliable decision-making. Many patients and families do not wish to pursue life supporting or life prolonging therapies. In LTC, palliative treatment options are often preferred overaggressive life supporting therapies. Understanding a patient’s wishes is General Management ♦ Analgesics/antipyretics for pain and fever ♦ Cough suppressants are not routinely recommended CONTINUING MANAGEMENT ♦ In the nursing home setting, the care team needs to be involved in daily assessments to alert the physician to significant changes in patient status:
often very challenging and it is imperative that all health care professionals understand how decisions are made regarding individual patient care. It is important that every effort is made to determine a patient’s wishes regarding treatment. An enacted personal directive will greatly assist health care providers make the correct decisions where the patient is unable to direct care. Etiology and pathophysiology The microbiological demographics in LTC are not well understood and will vary between centres. Streptococcus pneumoniae (S. pneumoniae) is recognized as the most common organism in NHAP. One recent prospective study found a prevalance of 55% in patients transferred to hospi- tal with NHAP.^11 There are concerns with the development of penicillin resistant S. pneumoniae and the true preva- lance of atypical pathogens is not known. NHAP more closely resembles community-acquired pneumonia (CAP) than nosocomial pneumonia.The pathophysiology of NHAP is the same as for CAP. The most common pathogens are S. pneumoniae, H. influenzae and M. catarrhalis. Less common pathogens in NHAP are Legionella and Chlamydophilia pneumoniae , although C. pneumoniae is emerging as a pathogen in NHAP. Elderly patients are also more likely to be colonized with gram-negative organisms (especially if decreased functional status, institutionalized and multiple co-morbid illnesses). Tuberculosis (TB) should always be considered (espe- cially in the elderly) given that there is a 10 to 30 times increased incidence of TB in long term care residents. LTC residents account for 20% of all TB cases in older people.12,1^ There is a need to be mindful of TB admission screening findings such as old TB on chest X-ray or Mantoux testing results. Anerobes are not important pathogens in CAP. Although the elderly and patients in LTC have a higher incidence of aspiration, the role of anaerobes in this setting remains controversial. Anaerobic coverage is not recommended in NHAP unless there is severe periodontal disease, putrid sputum, or evidence of necrotizing pneumonia or lung abscess.^13 In up to 50% of cases, a viral infection precedes the development of pneumonia and undoubtedly plays a role in the pathogenesis of pneumonia.14,15^ Viruses may inhibit important host defences, including ciliary activity, neu- trophil function, and other lung defence mechanisms.^15 Cigarette smoke compromises mucociliary function and macrophage activity. Alcohol impairs the cough reflex, increases oropharyngeal colonization with gram-negative bacilli, and may inhibit immune mechanisms.^15 Elderly pa- tients are at increased risk of developing pneumonia due to multiple factors: increased number and severity of co morbidities, decreased mucociliary clearance, diminished cough reflex, increased aspiration, increased colonisation with gram-negatives, and depressed immune system.^15 Differential Diagnosis The most common causes of diagnostic confusion in this population are non-infectious cardiac and pulmonary disorders. Congestive heart failure (CHF) is a common disorder resembling NHAP. CHF may represent an exac- erbation of a pre-existing CHF resulting in shortness of breath for the patient thus resembling the presentation of NHAP. It may also co-exist with NHAP. Chest radiographs are the best way to diagnose NHAP. Patients with NHAP have segmental or lobar distribution of infiltrates as seen on chest X-rays. Patients with CHF will have a redistribution of vasculature to the upper lobes, usually accompanied by cardiomegaly. Pre-existing chest X-rays may reveal previous interstitial lung disease that can be confused with the appearance of NHAP. Fever of 38OC or more accompanied by pulmonary symp- toms suggests NHAP, especially when accompanied by a productive cough. However, in elderly patients, the febrile response may be blunted. Thus, the absence of fever is unhelpful in making the differential diagnosis. Pleural effusions can also cause diagnostic confusion in the diagnosis of pneumonia. Bacterial pneumonias, particu- larly due to S. pneumoniae and H. influenzae , may be ac- companied by pleural effusion. Pleural effusions without associated infiltrates are not pneumonia. Diagnosis Diagnosis of pneumonia is based on a patient’s history, co-morbidities, physical findings, and chest X-ray. Symp- toms of NHAP most commonly include fever, chills, dys- pnea, pleuritic chest pain, and cough. With increasing age, symptoms of infection may not be as apparent and physical signs may be diminished. Fever may be less commonly observed but delirium and confusion may be more common in this population. Delirium or acute confusion is found in 44.5% of elderly patients with pneumonia.^16 Tachypnea is the only physical sign for which a predictive value can be calculated for LTC residents. Normal respira- tory rate in the elderly is 16 to 25 breaths per minute.^10 A respiratory rate of > 25 breaths per minute has a sensitivity of 90% and a specificity of 95% for the diagnosis of pneu- monia.^17
Amoxicillin This provides very effective activity against S. pneumoniae even in cases of high level resistance to penicillin. Macrolide A macrolide may be added if there is underlying lung dis- ease such as COPD or in severe pneumonia. Macrolides are also effective against atypical pneumonia such as Chlamydophilia pneumoniae , Mycoplasma pneumoniae or Legionella. However, macrolide resistance in S. pneumo- niae exceeds 10% and coverage of Haemophilus spp may not be optimal. Azithromycin has no appreciable serum concentrations and should not be used in patients with rigors/chills as this may indicate bacteremia. Cefuroxime May be considered in cases of penicillin allergy or post influenza pneumonia where Staph aureus may be a potential pathogen. Doxycycline S. pneumoniae resistance is known to be low (Capital Health authority 5%) and makes this an excellent choice. Many physicians have reported excellent clinical results using doxycycline in the management of NHAP. Respiratory fluoroquinolones Levofloxacin and moxifloxacin provide excellent coverage of the pathogens involved, but because of their broad spectrum and potential for increasing resistance in S. pneumoniae , they should be reserved for patients who 1) have failed first line therapy or 2) are elderly and have co morbidities. Ciprofloxacin does not have adequate coverage of S. pneumoniae and should not be used in the management of NHAP. Antibiotic resistance has become a significant issue among US nursing homes. Heavy utilization of the fluo- roquinolone group of antibiotics has contributed to the development of resistance due to their widespread empiric use.^27 Antibiotic resistant organisms are currently felt to be a less significant issue in Canadian centres due in large part to the restricted use of fluoroquinolones. Hospitalisation Thirty-three out of 1000 nursing home residents are hospi- talised with NHAP versus 1.14 per 1000 population who require hospitalisation due to CAP.^14 For patients with NHAP, referral to acute care for a more supported treatment environment should be considered in the following circumstances:
rEFErENCES
APPENDIX 1: ASPIrATION PNEUMONIA^29 Definitions
APPENDIX 2: INFLUENZA AND PNEUMOCOCCAL vACCINES30- Influenza vaccine should be given annually to: High risk: