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HEPATITIS AND HEPATITIS VIRUSES, Study notes of Pathology

Datta Meghe Institute of Medical SciencesPathology

THE NOTES ARE ALL ABOUT DISEASE HEPATITIS AND HEPATITIS VIRUS , THEIR SPREAD , MORPHOLOGY , CLINICAL FEATURES, SYMPTOMS , DIAGNOSIS AND LASTLY THE TREATMENT . ALL ARE COVERED.

Typology: Study notes

2020/2021

Available from 10/04/2022

Aryadahane
Aryadahane 🇮🇳

4 documents

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bg1
Hepatitis
☐
Hepatitis
-
A
virus
-
It's
a
self
climbing
disease
and
don't
lead
to
chronic
hepatitis
/
carries
stale
*
Epidemiology
-
←
unseen
①
Spread
→
contaminated
food
in
'
tho
itary
☒
Few
-
oral
contamination
"
"
[
By
consumption
of
Raw
/
steamed
shellfish
✗
[
oyster
,
mussels
,
clams
]
Sexual
transmission
NOTE
Maternal
-
fetal
transmission
⊕
#
Sntcucture
of
HAV
y
Non
-
enveloped
2)
+
ve
strand
RNA
3)
icosahedral
capsid
a)
27mm
diameter
5)
hepatocytes
have
receptors
for
HAV
󲰛
HAV
ce
-1
pf3
pf4
pf5
pf8
pf9
pfa

Partial preview of the text

Download HEPATITIS AND HEPATITIS VIRUSES and more Study notes Pathology in PDF only on Docsity!

Hepatitis

☐ Hepatitis

  • A virus -

It's a

self climbing disease (^) and don't

lead to chronic

hepatitis / carries stale

Epidemiology

← unseen (^) ① Spread → contaminated^ food in '

tho
itary ☒

" Few - oral contamination " [

By

consumption of^

Raw / steamed^

shellfish

✗ [ oyster , mussels ,

clams]

Sexual transmission

NOTE Maternal- fetal transmission^ ⊕

# Sntcucture

of HAV

y Non^ - enveloped

  1. +ve^ strand^ RNA
  2. icosahedral^ capsid a) 27mm^ diameter

hepatocytes have (^) receptors for HAV HAV^ ce^ -

Clinical^ Features

D Incubate^ period

  • 2 to (^6) weeks

IgM

  • appears with^ onset^ of symptoms ( short^
I

persist (^) for

3-6 months

duratn)

IgG anti - HAI - appears during recovery from acute^ infection +^ persist (^) far years giving lifelong^ immunity (^) against Hau^ .

  1. (^) symptoms ÷ Acute
D

Fatigue

disi

&

toss

of Appetite

  1. Jaundice
  2. Pt^.^ recover^ within (^3) months (^16) G) Chances^ of Acute (^) liver failure
  • (^) 0.11-a3 (^) %
  1. Rash^ 8)^ Arthralgia
  2. (^) leukocyte clastic^ vasculitis Glomerulonephritis Cryoglobulin emia

→ (^) It's member of Hepadnauieidae^ family → (^) Envelope → viral proton +^

host derived^ peoteins

  • vieal

polymerase

  • vocal^ DNA
→ HBI

genome Is circular (^) DNA to ① Hepatitis^ Bswfau Ag has 3 deleted^ vocal enveloped glycoproteins → target , associated (^) c- (^) complete uieion

→ Middle

→ & mall^ →^ No^ uieal^ ease element^ + targe (^) quantity

Mai release^ ↑

②Hepatitis^

B Core

Ag

  • CH Bc Ag] f) Nucleocapsid protein^

assembling complete

vision

→ tongue polypeptide^ →^ HBE Ag ③ HBO^ polymerase CPOD →^ Exhibits^ →^ DNA (^) polymerase

Reverse teams ceiptase

⑥ (^) Hepatitis B-✗^ protein (^ HB^ a)^ activity Act as^ transcript "' teamsactivator^ of reseal+^ host genes

☒ Hbsttg binds Ha - Jaurocho late coteanspoling

polypeptide

CNTCD
Bile

transporter ↓

  • Vital^

genome

enters (^) Nitens Cofhost CRN A)

To (^) synthesize → covalently closed ciecwlar DNA ☒cc] (^) DNA Reverse transcription

# Ideal^ RNA^ - DNA

c. (^) RNAintermediates

Clinical^

Features

D (^) HBI (^) has prolong incubate

period

→ (^41026) hleekg

HBsAy appears^ before onset of symptoms & peaks in^ acute^ symptomatic disease^. It (^) can (^) persist to^ chronicity

  1. Anti^
  • HBS Ab → steals wising after
resolute

of acute disease i. (^) e. after disappearance of^

HBS

Ag → check^ → IgM -^ anti-^ HBC^ antibody

Infants (^) acquiring

  • HBI (^) @ tooth

; those

are at^

high

aisle

of hepatocellular

carcinoma

  • dacciuati.cn^ → anti^ -^ Hiss^ Aboeesponse tuehg Treatment with ①^ interferons I ② (^) Reverse (^) transcriptase inhibitor is^ done eg : (^) Tenofouie
  1. HEPATITIS^
  • C (^) Nicks (^7) , ① (^) Meee ad^ parenteral Flauiuieiadl

Iv drug abuse

Multiple contact Multiple^ Sox^ partners with (^) Needle (^) stick injury nw infected pt . Hani uieidae^ family

as RNA^ views → hinllve

Envelope +

we 2 envelope glycoprotein^

  • PE ' → (^) Ez

Hepaciueauses

  • (^) Genus
  • scare^ proteins D PT
  1. NS^2
  2. NS^3

protease

  1. NSSA^
  • replication complex
5) N^5513 - RNA

polymerase

  • Incubation period (^) of HCV^
→ he to 20 weeks

with (^) mean of (^9) weeks

  • (^) Anti (^) HCV (^) Ab emerges (^3106) weeks after (^) infect

Assay for^

anti -^ Hcv^ Ab^ →^ use as

screening test for tech ↓

  • (^) there chronic disease (^) occurs in 80 -90% of HCV infected

people &^

209° progress to cirrhosis (^) over 20 - (^) 30%

35mm double^ shelled (^) particle

→ ext.^ coat^ Ag of^ Hou → (^) int - polypeptide assembly D-

ssRNA
  • aliens replicator
is

through RNA directed (^) RNA synthesis (^) by host (^) RNA

polymerase

Clinical^ Feature

D (^) Coihfeutn

  • Exposure to (^) serum contacting both (^) HDUIHBN