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HMP Shunt involved in Carbohydrate Metabolism, Lecture notes of Biochemistry

Sanjay Ghodawat University Biochemistry

The pentose phosphate pathway is a metabolic pathway parallel to glycolysis. It generates NADPH and pentoses as well as ribose 5-phosphate, a precursor for the synthesis of nucleotides. While the pentose phosphate pathway does involve oxidation of glucose, its primary role is anabolic rather than catabolic.

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2020/2021

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HMP Shunt

Dr. Vishwajeet S. Ghorpade

M. Pharm., PhD

Partial preview of the text

Download HMP Shunt involved in Carbohydrate Metabolism and more Lecture notes Biochemistry in PDF only on Docsity!

HMP Shunt

By

Dr. Vishwajeet S. Ghorpade

M. Pharm., PhD

Learning Objectives

After completion of this video, you will be able

to:

• Describe the oxidative and non-oxidative

phases of Hexose Monophosphate Shunt.

• State the significance of HMP Shunt.

HMP Shunt

• Also known as Pentose Phosphate Pathway OR

Phosphogluconate Pathway.

• Products formed:

Pentoses NADPH

Use:

Synthesis of DNA, RNA, CoA, NADH,

FADH 2 in rapidly dividing cells (bone

marrow, skin, intestinal mucosa)

Use:

Prevention & Repair of damage

caused due to oxygen radicals.

Synthesis of fatty acids, cholesterol

and steroid hormones (liver, adipose,

adrenal glands, gonads)

Overview of HMP Shunt

This Image belongs to Lehninger Principles of Biochemistry (4th^ edition) By D. Nelson & M. Cox.

Oxidative Phase of HMP Shunt

STEP 2:

This Image belongs to Lehninger Principles of Biochemistry (4th^ edition) By D. Nelson & M. Cox.

Oxidative Phase of HMP Shunt

STEP 3:

This Image belongs to Lehninger Principles of Biochemistry (4th^ edition) By D. Nelson & M. Cox.

Non-oxidative Phase of HMP Shunt

This Image belongs to Lehninger Principles of Biochemistry (4th^ edition) By D. Nelson & M. Cox.

Non-oxidative Phase of HMP Shunt

• Transketolase: Catalyzes transfer of two carbon

fragment from ketose donor to aldose acceptor.

It requires TPP cofactor for stabilization of

carbanions.

• Transaldolase: Catalyzes transfer of three carbon

fragment from ketose donor to aldose acceptor.

This Image belongs to Lehninger Principles of Biochemistry (4th^ edition) By D. Nelson & M. Cox.

Non-oxidative Phase of HMP Shunt

This Image belongs to Lehninger Principles of Biochemistry (4th^ edition) By D. Nelson & M. Cox.

• STEP 2:

Non-oxidative Phase of HMP Shunt

This Image belongs to Lehninger Principles of Biochemistry (4th^ edition) By D. Nelson & M. Cox.

• STEP 3:

HMP Shunt

This Image belongs to Lehninger Principles of Biochemistry (4th^ edition) By D. Nelson & M. Cox.

HMP Shunt involved in Carbohydrate Metabolism, Lecture notes of Biochemistry

Related documents

Partial preview of the text

Download HMP Shunt involved in Carbohydrate Metabolism and more Lecture notes Biochemistry in PDF only on Docsity!

HMP Shunt

By

Dr. Vishwajeet S. Ghorpade

M. Pharm., PhD

Learning Objectives

After completion of this video, you will be able

to:

• Describe the oxidative and non-oxidative

phases of Hexose Monophosphate Shunt.

• State the significance of HMP Shunt.

HMP Shunt

• Also known as Pentose Phosphate Pathway OR

Phosphogluconate Pathway.

• Products formed:

Pentoses NADPH

Use:

Synthesis of DNA, RNA, CoA, NADH,

FADH 2 in rapidly dividing cells (bone

marrow, skin, intestinal mucosa)

Use:

Prevention & Repair of damage

caused due to oxygen radicals.

Synthesis of fatty acids, cholesterol

and steroid hormones (liver, adipose,

adrenal glands, gonads)

Overview of HMP Shunt

Oxidative Phase of HMP Shunt

STEP 2:

Oxidative Phase of HMP Shunt

STEP 3:

Non-oxidative Phase of HMP Shunt

Non-oxidative Phase of HMP Shunt

• Transketolase: Catalyzes transfer of two carbon

fragment from ketose donor to aldose acceptor.

It requires TPP cofactor for stabilization of

carbanions.

• Transaldolase: Catalyzes transfer of three carbon

fragment from ketose donor to aldose acceptor.

Non-oxidative Phase of HMP Shunt

• STEP 2:

Non-oxidative Phase of HMP Shunt

• STEP 3:

HMP Shunt

• Significance:

Production of Pentoses and NADPH which are

required for various biochemical reactions and

functions.

References

• Biochemistry (4th^ edition) By U. Satyanarayana

• Lehninger Principles of Biochemistry (4th

edition) By D. Nelson & M. Cox