Idiopathic Sudden Deafness
: risk factors
from a case-control study
using pooled controls
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Risk Factors for Idiopathic Sudden Deafness: A Case-Control Study, Slides of Public Health
Information on a case-control study investigating the risk factors for idiopathic sudden deafness in japan. The study analyzes data from pooled controls and assesses dietary factors, traditional cardiovascular risk factors, and hearing loss patterns. The document also discusses proposed etiological mechanisms and the inner ear structure.
Typology: Slides
2012/2013
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Idiopathic Sudden Deafness
: risk factors
from a case-control studyusing pooled controls
Learning objectives
To learn •^ Definition of idiopathic suddendeafness •^ Analyses using a database of pooledcontrols •^ Qualitative assessment on diet
Proposed etiological
mechanisms
-^ Vascular impairment •^ Viral infection •^ Others
Blood supply in CochleaSubclavian artery
Vertebral artery Basilar artery
Anterior inferior cerebellar arteryCommon cochlear arteryCommon modiolar vein
arterioles and venules intricate capillary beds
Cochlea
Aim of a case-control studyTo know • Associations of traditionalcardiovascular risk factors • Similarities and differences of theassociations among types of hearingloss
Cases
-^ October 1996 - August 1998 •^ Patients diagnosed with idiopathicsudden deafness according to criteriaestablished by Japan’s SuddenDeafness Research Committee •^ Having an audiogram within 14 daysof onset
Patterns of hearing loss
definition
-^ High-frequency hearing loss •^ Low-frequency hearing loss •^ Flat-type hearing loss •^ Profound hearing loss •^ Other
Patterns of hearing loss
(mean-SD)
2 5 0 H z^ 5 0 0 H z^ 1 kH z
2 kH z^ 4 kH z^
8 kH z
dB 0^120
2 5 0 H z^ 5 0 0 H z^ 1 kH z
2 kH z^ 4 kH z^
8 kH z
2 5 0 H z^ 5 0 0 H z^ 1 kH z
2 kH z^ 4 kH z^
8 kH z
2 5 0 H z^ 5 0 0 H z^ 1 kH z
2 kH z^ 4 kH z^
8 kH z^
2 5 0 H z^ 5 0 0 H z^ 1 kH z
2 kH z^ 4 kH z^
8 kH z
High-frequency (n=20)
Low-frequency (n=31)
Flat-type (n=54)
Profound (n=20)
Other (n=39)
Low^
High
Questionnaire
-^ Identical for cases and controls •^ Food intake frequencies, tobacco,alcohol, sleeping hours, etc
Statistical methods
-^ m : n matching •^ Odds ratios and 95% confidenceintervals were estimated usingconditional logistic regression forgroup matching, where the matchingvariables were age, gender, andresidential district
Second factor Factor analysis^ 0.
"Japanese"foods "Western" foods^32451
(^67) (^9101119831152734)
(^3012 1723 )
(^24 ) (^1326332128) 2918 32 20 35
Firstfactor
0
Line of Equality
“Western” food intake • Calculated by summing thefrequencies of intake for each of thefoods in the “Western” food group • On the basis of these scores:frequent intake (highest quartile)moderate intake (middle twoquartiles) infrequent intake (lowestquartile)
Odds ratios of sudden deafnessfor “Western” food intake 4.0 3.0 2.0 1.0 0.
Infrequent
Moderate
Frequent
All types
High-frequency
Low -frequency
Flat-type
Profound
Other
Odds ratios of sudden deafnessfor “Japanese” food intake 4.0 3.0 2.0 1.0 0.
Infrequent
Moderate
Frequent
All types
High-frequency
Low -frequency
Flat-type
Profound
Other