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Immune System and Liver Diseases, Exams of Nursing

An overview of various aspects of the immune system and liver diseases. It discusses the concept of memory b cells and how they create antibodies when exposed to an antigen, as well as examples of how passive immunity can be acquired, such as through mother-to-fetus transmission, breastfeeding, and blood transfusions. The document also covers different types of jaundice, including hemolytic jaundice, and the associated symptoms and medical management. Additionally, it delves into hepatitis a, b, and c, their transmission, symptoms, and prevention. The document also touches on hypothyroidism, hypoparathyroidism, hyperglycemic hyperosmolar syndrome, and acute pancreatitis, discussing their causes, clinical manifestations, and nursing interventions. Overall, this document provides a comprehensive understanding of the immune system and various liver-related diseases, making it a valuable resource for students and healthcare professionals.

Typology: Exams

2023/2024

Available from 08/07/2024

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Albany State University Nursing Division NURS 2115 Spring
2017 Metabolic Disorder Study Guide
The guide is meant to help focus on study topics. Liver disorders will be half
of the metabolic items on the test. The emphasis will be on nursing care and
decision- making.
1. Know the difference between legal and ethical action in nursing.
2. Examine cultural considerations when treating client conditions.
3. Understand the difference between active and passive immunity. Give
an example of passive immunity in adults.
Active Immunity
immunologic defenses developed by the persons own body.
Last many years or even a lifetime
Creates memory B cells make antibodies when exposed to an
antigen you were previously exposed to
Examples
Get sick and body makes antibodies
Immunizations and vaccinations
Passive Immunity
Immunity transmitted from a source outside the body that has
developed immunity through previous disease or immunization.
Temporary immunization
Examples
Mother to fetus through placenta
Mother to newborn through breastmilk
IV immunoglobulins (Passive Immunoglobulins) this way
the body doesn’t have to create the immunoglobulins
Blood transfusion from someone who was previously
infected or vaccinated
4. Discuss the signs and symptoms of liver disorders.
Integumentary changes
Jaundice
When the bilirubin concentration in the blood is abnormally
elevated , all of the bodies tissues, including the sclera and skin,
become tinged yellow or greenish yellow. (pg 1342)
This becomes clinically evident when the bilirubin levels
exceed 2.5mg/dL
Increased levels may result from impairment of hepatic uptake,
conjugation of bilirubin, or excretion of bilirubin into the biliary
system.
Different types of jaundice
Hemolytic jaundice (Pg. 1343)
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Albany State University Nursing Division NURS 2115 Spring

2017 Metabolic Disorder Study Guide

The guide is meant to help focus on study topics. Liver disorders will be half of the metabolic items on the test. The emphasis will be on nursing care and decision- making.

  1. Know the difference between legal and ethical action in nursing.
  2. Examine cultural considerations when treating client conditions.
  3. Understand the difference between active and passive immunity. Give an example of passive immunity in adults. ❖ Active Immunity ➢ immunologic defenses developed by the persons own body. ➢ Last many years or even a lifetime ➢ Creates memory B cells make antibodies when exposed to an antigen you were previously exposed to ➢ Examples ▪ Get sick and body makes antibodies ▪ Immunizations and vaccinations ❖ Passive Immunity ➢ Immunity transmitted from a source outside the body that has developed immunity through previous disease or immunization. ➢ Temporary immunization ➢ Examples ▪ Mother to fetus through placenta ▪ Mother to newborn through breastmilk ▪ IV immunoglobulins (Passive Immunoglobulins) this way the body doesn’t have to create the immunoglobulins ▪ Blood transfusion from someone who was previously infected or vaccinated
  4. Discuss the signs and symptoms of liver disorders. ❖ Integumentary changes ➢ Jaundice ▪ When the bilirubin concentration in the blood is abnormally elevated , all of the bodies tissues, including the sclera and skin, become tinged yellow or greenish yellow. (pg 1342) ▪ This becomes clinically evident when the bilirubin levels exceed 2.5mg/dL ▪ Increased levels may result from impairment of hepatic uptake, conjugation of bilirubin, or excretion of bilirubin into the biliary system. ▪ Different types of jaundice - Hemolytic jaundice (Pg. 1343)

◆ Is the result of increased destruction of red blood cells which rapidly floods the plasma with bilirubin to the extent that a normally working liver cannot excrete the bilirubin as quickly as it is formed. ◆ Patients with this kind of jaundice, unless extreme, do not experience symptoms or complications other than jaundice but prolonged jaundice will predispose the formation of pigment stones in the gallbladder

  • Hepatocellular Jaundice (pg. 1344) ◆ Caused by the inability of the damaged liver cells to clear normal amounts of bilirubin from the blood. ◆ Liver cell damage can be caused by hepatitis, other viruses (Epstein Barr), chemical toxins, or alcohol. ◆ These patients may be mildly or severely ill with lack of appetite, nausea, malaise, fatigue, weakness, and possible weight loss.
  • Obstructive Jaundice (Pg. 1344) ◆ Cause by extrahepatic or intrahepatic obstruction ➢ Extrahepatic obstruction is caused by occlusion of the bile duct from a gallstone, an inflammatory process, a tumor or pressure from enlarged organ. ➢ Intrahepatic obstruction is caused by stasis and inspissation (Thickening) of the bile with in the canaliculi. ◆ Both cause bile to be unable to flow normally into the intestine causing it to back up in the liver where it is reabsorbed and carried out into the entire body, staining the skin, mucosa, and sclera. It is also excreted through urination causing urine to become deep orange and foamy. Stools will also become clayed colored because of lack of bile in intestine. Pts skin will also itch intensely.
  • Hereditary Hyperbilirubinemia (Pg.1344) ◆ Results from inherited disorders such as Gilbert’s syndrome, Dublin-Johnson syndrome, and Rotor’s syndrome ❖ Portal HTN (Pg., 1344) ➢ Results from obstruction of blood flow into and through a damaged liver. ➢ Commonly associated w/hepatic cirrhosis. ❖ Ascites (Pg. 1344 – 1349) ➢ Caused ▪ by failure if the liver to metabolize aldosterone increases sodium and water retention by the kidneys. Na and h2o retention, increased intravascular fluid volume, increased lymphatic flow,

Umbilical hernias occur freq. Also will present with some fluid and electrolyte imbalances. ➢ Assessment ▪ Palpation, Percussion and fluid wave test. ➢ Management ▪ Nutritional

  • Goal is a negative sodium balance to reduce fluid retention.
  • Table salt, salty foods, salted butter, canned foods, and frozen foods not specifically prepared for low sodium diet should be avoided. ▪ Pharmacological
  • Diuretics ➢ Spironolactone is first line therapy. When used with other diuretics it helps prevent potassium loss. ➢ Furosemide may be added but use with caution b/c long term use can lead to hyponatremia. ➢ Daily weight loss should not exceed 1-2kg (2.2-4.4lb) ◆ Complications ➢ Avoid use of ammonium chloride and acetazolamide because these drugs can precipitate hepatic coma. ➢ Diuretic complications are fluid and electrolyte imbalances and encephalopathy cause by dehydration
  • Bed Rest ◆ Patient needs to be in an upright posture to activate renin- angiotensin- aldosterone system.
  • Paracentesis ◆ Is the removal of fluid from the peritoneal cavity through a puncture or small surgical incision through the abdominal wall under sterile conditions. ◆ Large volume (5-6L) paracentesis has been shown a safe method for treating patients with severe ascites. ◆ Only provides temporary removal of fluid. ◆ Nursing Care for patient undergoing paracentesis ➢ Pre-procedure ▪ Check signed consent form, educate, instruct pt to void, gather materials, place patient in upright position on edge of bed or in a chair with feet supported by a stool. Fowlers position for pt confined to bed. Place a sphygmomanometer cuff around pts arm ➢ Procedure ▪ Help pt maintain position, measure and record BP at frequent intervals, monitor pt for signs of vascular collapse (pallor, increased pulse, decreased BP)

➢ Post Procedure ▪ Place pt in comfortable position, measure, describe and record fluid collected, send sample to lab, monitor VS q15 mins for 1hr, then q30 mins for 2 hours, then q1hr for 2hrs,

lozenges and gargles may be used to comfort sore throat. ➢ If pt is actively bleeding oral intake will not be permitted b/c further test will be needed. ▪ Portal HTN measurements

  • Indirect measurement of hepatic vein pressure is most common. This is done by inserting a catheter w/balloon into the antecubital or femoral vein to the hepatic vein. Once in position the balloon is filled with fluid and a wedge pressure is obtained.
  • Direct measurement includes a Laparotomy that consist of a needle being introduced into the spleen taking a manometer reading, greater than 20 ml is abnormal. ➢ Medical Management
  • Pharmacologic, endoscopic, and surgical are used to treat bleeding esophageal varices, but none are ideal and most have considerable risk.
  • Nonsurgical tx of bleeding varices is preferred b/c of the high mortality rate of emergency surgery and b/c of the poor physical condition typical of a pt with severe liver disease. ▪ Volume Resuscitation
  • b/c pts w/bleeding varices have intravascular volume depletion and are subject to electrolyte imbalances, IV fluids, electrolytes, and volume expanders are provided to restore volume.
  • Blood transfusion may also be required.
    • Caution has to be taken with volume resuscitation so that over hydration does not occur b/c this will raise the portal pressure and increase the bleeding you are trying to control.
  • Indwelling catheter is also in place during this to monitor urine output. ▪ Pharmacological Tx ◆ * in suspected variceal bleeding vasoactive drugs need to be given ASAP and BEFORE endoscopy.
  • Octreotide (Sandostatin) ◆ Preferred tx regimen for immediate variceal bleeding b/c it lacks the vasoconstrictive effects of vasopressin. ◆ These meds cause selective splanchnic vasoconstriction by inhibiting glucagon release and are used mainly in the management of active hemorrhage.
  • Vasopressin ◆ Only used in urgent situations. ◆ Contraindicated for pts with CAD b/c of coronary vasoconstriction effects but can be given with nitroglycerine to counteract those effects. ◆ Has to be administered with close monitoring b/c of side effects.
  • Beta-Blockers (propranolol & nadolol) ◆ Used as a prophylactic to decrease portal pressure in pts to prevent a first bleeding episode or to prevent recurrent bleeding episodes

◆ Asphyxiation by displacement of the tube, inflation of tube in oropharynx, and rupture of the balloon. ➢ Nurse Intervention ▪ Inflate balloon before insertion to ensure balloon can handle the required pressure without rupture ▪ **Keep scissors at bedside to cut tube in an emergency ◆ Aspiration, especially in stuporous or comatose pts. ➢ Intubation may be required to ensure the pts airway is protected ◆ Ulceration and necrosis of the nose, the mucosa of the stomach, or the esophagus may occur if the tube is left in place to long, inflated to long, or inflated at too high of a pressure ➢ Nursing intervention ▪ Frequent mouth and nasal care, oral suctioning. ▪ Endoscopic Variceal Ligation (EVL) (Banding) (pg 1352)

  • Is a method of placing a band around the varices to cause necrosis, ulceration, and eventually sloughing of the variceal.
  • EVL is the Tx of choice to treat varices b/c it significantly reduces re- bleeding rates, mortality, procedure related complications, and reduces the number of sessions needed to eradicate varices.
  • Complications ◆ Superficial ulceration and dysphagia, transient chest discomfort, and rarely esophageal strictures.
  • Recommended for pts who have experienced bleeding while receiving beta-blocker therapy or those who cannot tolerate beta therapy ▪ Endoscopic Sclerotherapy (pg 1352)
  • Is a method of injecting a sclerosing agent into or adjacent to the bleeding varices to promote thrombosis and eventual sclerosis.
  • Not recommended for prevention of first or subsequent variceal bleeding episodes.
  • After TX ◆ Observe for bleeding, perforation of esophagus, aspiration pneumonia, and esophageal stricture. ◆ Antacids and h2 antagonist may be given to counteract the effects of sclerosing agent on esophagus and for reflux associated with procedure ▪ Trans-jugular Intrahepatic Portosystemic Shunt (TIPS) (Pg. 1352)
  • Used to divert blood flow and reduce portal HTN
  • Is indicated for tx of an acute episode of uncontrolled variceal bleeding refractory to pharm or endoscopic therapy.
  • In 10-20% of pts whom urgent band ligation or sclerotherapy and medications did not stop bleeding, TIPS procedure can effectively control acute variceal hemorrhage.
  • Complications ◆ Bleeding, sepsis, HF, organ perforation, shunt thrombosis, and progressive liver failure.

➢ Medical Management ▪ Focuses on eliminating the precipitating cause such as ammonia lowering therapy, minimizing potential medical complications of cirrhosis and depressed consciousness, and reversing underlying liver disease.

▪ Correction of reason for deterioration such as bleeding, electrolyte abnormalities, sedation, or azotemia (high levels of nitrogen containing compounds in the blood) is essential. ➢ Pharmacological Management ▪ Lactulose

  • Used to reduce serum ammonia levels by trapping and expelling ammonia in feces.
  • Two or three soft stools per day indicates that lactulose is preforming as intended ◆ Watery diarrhea stools indicate medication overdose!
  • Side Effects include intestinal bloating and cramps.
  • Other laxatives are not prescribed during lactulose therapy.
  • May be admin via NG tube or enema for comatose pts or for those who oral admin is contraindicated
  • Pt teaching ◆ If sweet taste is dislike pt can dilute with fruit juice. ▪ IV glucose is given to minimize protein breakdown ▪ Vitamins to correct deficiencies and electrolyte imbalances ▪ Antibiotic to decrease ammonia forming bacteria in the colon.
  • No benefit has been shown for long term antibiotic tx ▪ Discontinue sedatives, tranquilizers, and analgesic medications ➢ Nutritional Management ▪ Low protein diet w/small frequent meals and snacks, substitute veggie proteins for animal proteins. ➢ Nursing Management ▪ Assess neuro freq, keep daily record of handwriting and arithmetic performance, I&O and body weight recorded daily, assess peritoneum and lungs for infection each day, monitor ammonia levels. ▪ Maintain safe environment, encourage deep breathing and position changes, communicate with family about pt status, and explain procedures and txs that are a part of care.
  1. Describe physical assessments of liver function. ❖ Inspection ➢ Liver is normally not visualized so if you can see a liver in the upper right quadrant there should be suspicion of disease ❖ Palpation ➢ Palpated in the upper right quadrant to assess size and to detect any tenderness. ➢ This is done by placing one hand under the lower right rib cage and pressing downward during inspiration with the other had at the lower right rib cage. (Bimanual Technique) ➢ Palpable liver presents as a firm sharp ridge with a smooth surface. ▪ If palpable nurse notes and records size, consistency, any

➢ Used to determine size and tenderness ➢ To note size, the examiner percusses the upper and lower boarders of the liver and marks them so they can be measured in cm. (Normal Size 6-12 cm) ➢ If tenderness is suspected, tapping the lower right thorax briskly may elicit tenderness. For comparison preform the same on the opposite side.

  1. Know lab tests used to examine liver function. What are the normal values for each test? Apply lab results to patient situations. ❖ Alanine Aminotransferase (ALT) ➢ Normal 5-35 units ➢ Used to identify liver disease, especially Cirrhosis and Hepatitis, caused by alcohol, drugs or viruses ➢ Used to keep track of medications effects on the liver. ➢ Also used to identify whether jaundice is cause by blood disorder or from liver disease ❖ Aspartate Aminotransferase (AST) ➢ Normal 10-40 units
    ➢ Used for the same as ALT ❖ Gamma Glutamyl Transferase (GGT) ➢ Normal 10-48 IU/L ➢ Used to detect some liver disease and bile duct obstructions ➢ Used also to screen for chronic alcohol abuse, Elevated in ETOH (Alcohol) abuse. ❖ Alkaline Phosphate (ALP) ➢ Normal 20-140 IU/L ➢ Sensitive to biliary obstruction ❖ Ammonia ➢ Normal 10-65 umg/dl ➢ Elevated in severe liver disease ➢ Used to help diagnose hepatic encephalopathy ❖ Albumin ➢ Normal 4-5.5 g/dl ➢ Affected in cirrhosis, chronic hepatitis, edema and ascites. ❖ Total Bilirubin ➢ Normal < 0.9 mg/dl ➢ Abnormal in liver and biliary tract disease ❖ Prothrombin Time (PT) ➢ Normal 12-16 seconds ➢ Prolonged in liver disease and will no return to normal w/K+ in severe liver damage.
  2. Describe procedures used to diagnose and treat liver disorders, and related nursing actions. Discuss nursing actions and interventions related to procedures.

❖ Liver Biopsy ➢ The removal of a small amount of liver tissue, usually through needle aspiration, to examine liver cells.

  • In which scarring occurs in the liver around the bile ducts.
  • Usually the result from chronic biliary obstruction and infection (cholangitis)
  • Much less common ➢ Clinical Manifestations ▪ Two Categories by severity (Compensated and Decompensated
  • Compensated cirrhosis is less severe and has vague symptoms that are usually discovered secondary to a routine physical examination.
  • These symptoms include: ◆ Intermittent mild fever, vascular spiders, palmar erythema (reddened palms), unexplained epistaxis, ankle edema, vague morning indigestion, flatulent dyspepsia (swelled stomach, felling full w/o eating), abdominal pain, firm enlarged liver, and splenomegaly.
  • Decompensated Cirrhosis results from failure of the liver to synthesize proteins, clotting factors, and other substances and manifestations of portal HTN.
  • Symptoms of Decompensated: ◆ Ascites, jaundice, weakness, muscle wasting, weight loss, continuous mild fever, clubbing of fingers, purpura (rash of purple spots), spontaneous bruising, epistaxis, hypotension, sparse body hair, white nails, gonadal atrophy. ▪ Other manifestations
  • Liver enlargement ◆ Early stages the liver is large, firm and sharp on palpation, abdominal pain because of the liver being stretched. ◆ Later stages the liver decreases in size because of fibrous tissue and if palpable will be nodular
  • Portal Obstruction and Ascites ◆ Late manifestations cause by failure of liver function and by obstruction of portal circulation
  • Infection and Peritonitis ◆ May develop in pts with cirrhosis and ascites in the absence of intra-abdominal source of infection or abscess ◆ Translocation of intestinal flora is believed to be the cause
  • Gastrointestinal Varices ◆ Caused by shunting of blood from the portal vessels into blood vessels with lower pressures which causes these vessels to distend and form varices or hemorrhoids depending on location.
  • Edema ◆ Liver failure causes a reduced plasma albumin concentration which predisposes the pt to edema mainly in the lower extremities, upper extremities and the presacral area.
  • Vitamin deficiency and Anemia