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Material Type: Notes; Professor: Hendrix; Class: ELEM STATS/BIOL&LIFE SCI; Subject: Statistics; University: University of South Carolina - Columbia; Term: Fall 2009;
Typology: Study notes
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Agresti โ Caffo
Returning to the independent two sample case, suppose now the data are from a binomial setting with Y 1 ~ Bin(n 1 ,p 1 ) independent of Y 2 ~ Bin(n 2 ,p 2 )
Of interest is the difference p 1 โ p 2.
A good point estimator for p 1 โ p 2 is the difference in sample proportions
pเท 1 โpเท 2 เต
n 1 โ
n (^2)
But, again we will use the previous AC strategy for this confidence interval. Presented here is a 95% confidence interval.
Point Estimator Add one success and one failure to each sample.
pเทค 1 โpเทค 2 เต
n 1 เต 2 โ
n 2 เต
Critical Point Zฮฑ/2 = 1.
Standard Error of Point Estimator
SEแบpเทค 1 โpเทค 2 แป เตเถจ
pเทค 1 แบ1โpเทค 1 แป n 1 เต 2 เต
pเทค 2 แบ1โpเทค 2 แป n 2 เต
95% Confidence Interval for p 1 โ p 2
pเทค 1 โpเทค 2 เต Zฮฑ 2โ เถจ
pเทค 1 แบ1โpเทค 1 แป n 1 เต 2 เต
pเทค 2 แบ1โpเทค 2 แป n 2 เต 2 where pเทค^1 โpเทค^2 เต
n 1 เต 2 โ
n 2 เต
Note: Presented here is a 95% confidence interval โ generalizations exist for other levels of confidence.
Agresti Caffo Interval Page 2
Example 10.37 Angina pectoris is a chronic condition in which the sufferer has periodic attackes of chest pain. In a study to evaluate the effectiveness of the drug Timolol in preventing angina attacks, patients were randomly allocated to receive a daily dosage of either Timolol or placebo for 28 weeks.
Let Y 1 = number of patients angina free after Timolol Let Y 2 = number of patients angina free after placebo Compute and interpret a 95% confidence interval for the difference in proportion of angina free under Timolol versus placebo.