
























Study with the several resources on Docsity
Earn points by helping other students or get them with a premium plan
Prepare for your exams
Study with the several resources on Docsity
Earn points to download
Earn points by helping other students or get them with a premium plan
Community
Ask the community for help and clear up your study doubts
Discover the best universities in your country according to Docsity users
Free resources
Download our free guides on studying techniques, anxiety management strategies, and thesis advice from Docsity tutors
This comprehensive Notes covers the introduction to antimicrobial drugs, their classification, and detailed explanations of drugs that inhibit cell wall synthesis and protein synthesis. Learn about macrolides and their role in treating infections, along with essential insights into various antimicrobial agents. Perfect for students and professionals looking to deepen their understanding of pharmacology and microbiology.
Typology: Lecture notes
1 / 32
This page cannot be seen from the preview
Don't miss anything!
Introduction to Antimicrobial Drugs
. which
the growth of or kill other microorganisms at very low conct. Drug Resistance :
.
(a) Single step^ mutation (^) ( seen^ with^
&
mutation ( seen with Erythromycin ,^ tetracycline^ )
to other by (^) gene transfer^ .
Drug
Target
ciiii Alteration of Metabolic pathway in (^) Reduced drug accumulation.
MedNotes [ www.mednotes.in ] Full MedNotes : mednotesebooks.company.site App Available on PlayStore ( iiis^ Bactericidal^ drugs are^ used^ in^ immunocompromised patients , not^ bacteriostatic in some^ drugs
Tetracyclines
doxycycline
( vs Drugs contraindicated in^ liver^ disease^.
Classification of Antimicrobial Agents
ways : TA ] Mechanism^ of Action^ : ii. Drug inhibiting^ cell wall^ synthesis :
synthesis : ciiis Drugs (^) causing leakage^ from^ cell Membrane^ : car Polypeptide Antibiotics (^) : Polymixin B.^
and tyrothricin
(c) Arabinogalactan (^) synthesis inhibitors (^) : Ethambutol
[ B. ] Based (^) on Type of Action^ : ( is^ Bacteriostatic^ ( (^) stop the growth of bacteria (^) ) in (^) Bactericidal (^) ( kills bacteria ) (c) Based on spectrum (^) of (^) Activity : ( is^ Narrow^ Spectrum -^ Penicillin^ G
spectrum
Drugs Inhibiting Cell Wall Synthesis - 1
include : (a) Penicillins (b)
(c) Monobactams (d) (^) Carbapenems.
Penicillins
(a) Penicillin^ ases (^) ( B^ -^ lactamases^ ) break lactam^ ring .
staphylococci
(b) structural changes in PBPS^ of Bacteria^. ( (^) As :^ methicillin -^ resistant
aureus [ (^) MRSA] , (^) penicillin -^ resistant^ pneumococci.^ ) (c) Changes
shortcomings :
Penicillin enhanced if used in combination with P
0 - (^) Oxacillin D- Dicloxacillin [VODKA^ ] K -^ Cloxacillin
MedNotes [ www.mednotes.in ] Full MedNotes : mednotesebooks.company.site App Available on PlayStore
-^ N^ afcillin and^ Oxacillin^ eliminated^ largely in Bile.
.
. (b) GI^ distress^ , (^) esp. Ampicillin
of syphilis .
Drugs Inhibiting Cell Wall Synthesis - 2 Cephalosporins
.
anic acid (^) ).
-^ Most^ enter^ CMS^ :^ important in^ empiric management of^ Meningitis & Sepsis . 1- D^ ]^ Fourth^ Generation :
Imipenem & Meropenem
la > Hypersensitivity
Fever
in causing Neutropenia . Carbapenems
Resistant to p
Spectrum :
in - hospital (^) agents for^ empiric use in severe (^) life - threatening infections^ .
Full MedNotes : mednotesebooks.company.site
c
Drugs Inhibiting Protein Synthesis - 1
:
& Tetracycline (b) Moderate^ Spectrum
(c) Narrow^ spectrum : Lin (^) cos amides (^) , streptogramins and Oxazolidinones^. Mechanism & Site I