Class: Proton-pump Inhibitors
- Antiulcer Agents
- Gastric Antisecretory Agents
- Acid-pump Inhibitors
Brands: Prevacid, Prevpac
Mechanism of action
• Inhibits basal and stimulated gastric acid secretion
• Concentrates in acid conditions of parietal cell secretory canaliculi; forms active
sulfenamide metabolite that irreversibly binds to and inactivates hydrogen-
potassium ATPase (proton or acid pump), blocking final step in secretion of
hydrochloric acid
• Acid secretion is inhibited until additional hydrogen-potassium ATPase is
synthesized, resulting in prolonged duration of action
• Lansoprazole is a racemic mixture of
R
- and
S
-isomers. Both isomers inhibit
hydrogen-potassium ATPase. Combined therapy with lansoprazole and
appropriate anti-infectives (i.e., amoxicillin, clarithromycin) can effectively
eradicate
H. pylori
infection.
Dosage
Pediatric Patients
GERD
Oral
Children 1–11 years of age: In those weighing ≤30 kg, 15 mg once daily for up to
12 weeks. In those weighing >30 kg, 30 mg once daily for up to 12 weeks.
LANSOPRAZOLE
-LAVANYA
