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Lecture Notes on The Urinary System - Anatomy and Physiology |, Study notes of Physiology

Material Type: Notes; Class: Anatomy & Physiology; Subject: Biology / Biological Sciences; University: Florida Hospital College of Health Sciences; Term: Forever 1989;

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2009/2010

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Chapter 23
The Urinary System
I. Introduction
A. Functions of kidneys
1. Filter plasma โ€“ Filter plasma by eliminating wastes and returning useful
chemical
2. Regulate blood volume and pressure โ€“ by eliminating or conserving water
3. Regulate osmolarity โ€“ control water and solutes eliminated
4. Control blood pressure and electrolyte balance โ€“ secrete renin
5. Control RBC count โ€“ secrete erythropoietin
6. Regulate acid-base balance โ€“ secrete hydrogen
B. Nitrogenous waste โ€“ substance that is useless to the body (Fig. 23.2, pg. 907)
1. Urea โ€“ by-product of protein catabolism
2. Uric acid โ€“ by-product of nucleic acid catabolism
3. Creatinine โ€“ by-product of creatine phosphate catabolism
II. Anatomy of the kidney
A. Location (Fig. 23.3, pg. 909)
1. Against posterior abdominal wall at the level of T12-L3
2. Retroperitoneal
B. Layers (Fig. 23.3, pg. 909)
1. Renal fascia โ€“ Fibrous Connective tissue that binds the kidney to the
abdominal wall.
2. Perirenal fat capsule โ€“ cushions the kidney and holds it in place
3. Fibrous capsule โ€“ encloses the kidney and protects it
C. Renal parenchyma (Fig. 23.4, pg. 909)
1. Tissue that forms urine
2. Renal sinus โ€“ medial cavity occupied by blood vessels, lymph vessels,
nerves, and urine-collecting structures
3. Renal cortex โ€“ outer zone
4. Renal medulla โ€“ inner zone
a. Renal columns โ€“ extensions of the renal cortex that divide the
renal medulla
b. Renal pyramids โ€“ tissues that contains urine producing structures
c. Renal papilla โ€“ blunt point of the renal pyramid
5. Minor calyx โ€“ cusped
6. Major calyx โ€“ convergence of minor calyces forming a urine passageway
7. Renal pelvis โ€“ convergence of major calyces forming funnel-like drain for
urine
D. Renal circulation (Fig. 23.5, pg. 910)
1. Arteries โ€“ renal artery ๏ƒ  segmental artery ๏ƒ  interlobar artery ๏ƒ 
arcuate artery ๏ƒ  interlobular artery
2. Finer branches (Fig. 23.6, pg. 911)
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Chapter 23 The Urinary System I. Introduction A. Functions of kidneys

  1. Filter plasma โ€“ Filter plasma by eliminating wastes and returning useful chemical
  2. Regulate blood volume and pressure โ€“ by eliminating or conserving water
  3. Regulate osmolarity โ€“ control water and solutes eliminated
  4. Control blood pressure and electrolyte balance โ€“ secrete renin
  5. Control RBC count โ€“ secrete erythropoietin
  6. Regulate acid-base balance โ€“ secrete hydrogen B. Nitrogenous waste โ€“ substance that is useless to the body (Fig. 23.2, pg. 907)
  7. Urea โ€“ by-product of protein catabolism
  8. Uric acid โ€“ by-product of nucleic acid catabolism
  9. Creatinine โ€“ by-product of creatine phosphate catabolism II. Anatomy of the kidney A. Location (Fig. 23.3, pg. 909)
  10. Against posterior abdominal wall at the level of T 12 -L 3
  11. Retroperitoneal B. Layers (Fig. 23.3, pg. 909)
  12. Renal fascia โ€“ Fibrous Connective tissue that binds the kidney to the abdominal wall.
  13. Perirenal fat capsule โ€“ cushions the kidney and holds it in place
  14. Fibrous capsule โ€“ encloses the kidney and protects it C. Renal parenchyma (Fig. 23.4, pg. 909)
  15. Tissue that forms urine
  16. Renal sinus โ€“ medial cavity occupied by blood vessels, lymph vessels, nerves, and urine-collecting structures
  17. Renal cortex โ€“ outer zone
  18. Renal medulla โ€“ inner zone a. Renal columns โ€“ extensions of the renal cortex that divide the renal medulla b. Renal pyramids โ€“ tissues that contains urine producing structures c. Renal papilla โ€“ blunt point of the renal pyramid
  19. Minor calyx โ€“ cusped
  20. Major calyx โ€“ convergence of minor calyces forming a urine passageway
  21. Renal pelvis โ€“ convergence of major calyces forming funnel-like drain for urine D. Renal circulation (Fig. 23.5, pg. 910)
  22. Arteries โ€“ renal artery ๏ƒ  segmental artery ๏ƒ  interlobar artery ๏ƒ  arcuate artery ๏ƒ  interlobular artery
  23. Finer branches (Fig. 23.6, pg. 911)

a. Afferent arterioles โ€“ arise from the interlobular artery and supplies blood to a nephron b. Glomerulus โ€“ balls of capillaries that filter plasma and produces filtrate c. Efferent arteriole โ€“ the way blood leaves the glomerulus d. Peritubular capillaries โ€“ network around renal tubules, absorb water and solutes filtered out of the blood by the glomerulus e. Vasa recta โ€“ arise from an efferent arteriole and run parallel to nephron loops in the renal medulla

  1. Veins โ€“ interlobular vein ๏ƒ  arcuate vein ๏ƒ  interlobar vein ๏ƒ  renal vein E. Nephron โ€“ (1.2 million / kidney) โ€“ carries out the processes that form urine
  2. Renal corpuscle โ€“ filters blood plasma a. Glomerulus โ€“ filters plasma and produces filtrate b. Glomerular capsule โ€“ encloses glomerulus and collects filtrate c. Podocytes โ€“ cells that wrap around the glomerulus (Fig. 23.10)
  3. Renal tubule โ€“ converts filtrate to urine a. A duct that leads away from the glomerular capsule b. Proximal convoluted tubule (PCT) ๏ƒ  nephron loop (descending limb and ascending limb) ๏ƒ  distal convoluted tubule (DCT) ๏ƒ  Collecting duct (CD) c. Collecting ducts merge to form a papillary duct
  4. Cortical nephrons have short nephron loops located just beneath the renal capsule (Fig. 23.6, pg. 911)
  5. Juxtamedullary nephrons have long nephron loops that begin close to the medulla and extend to the pyramid apex III. Urine formation โ€“ Glomerular filtration A. Stages of urine formation (Fig. 23.9, p. 915)
  6. Glomerular filtration โ€“ water and some solutes in the blood pass from the capillaries to the capsular space of the nephron (creates a plasma like filtrate of the blood from the renal corpsule to cap)
  7. Tubular reabsorption โ€“ useful solutes from filtrate that are returned to the blood (Removes useful solutes from the filtrate, returns them to the blood and)
  8. Tubular secretion โ€“ wastes from the blood are added to the filtrate (Removes additional wastes from the blood and adds them to fifltrate)
  9. Water conservation โ€“ water from the urine is returned to the blood ( removes h20 from the urine and returns it to the blood, concentrates waste) B. Filtration membrane (Fig. 23.12, pg. 915)
  10. Glomerular capillary endothelium โ€“ Fenestrated with lg. filtration pores
  11. Basement membrane โ€“ holds back most large molecules
  12. Filtration slits โ€“ pedicels of podocytes interdigitate forming filtration slits
  13. Proteinuria โ€“ protein in urine
  14. Hematuria โ€“ blood in urine

d. Water and solutes leave the tubule cells and are reabsorbed into the blood by peritubular capillaries

  1. Tubular secretion a. Waste โ€“ urea, uric acid, ammonia, creatine b. Drugs โ€“ morphine, penicillin, aspirin c. H+- pumped into tubule using Na+-H+^ pump B. Nephron loop
  2. Generates a salinity gradient that allows the CD to concentrate urine
  3. Descending limb โ€“ reabsorbs water
  4. Ascending limb โ€“ reabsorbs Na+, K+, Cl- C. Distal convoluted tubule and collecting duct
  5. Fluid still contains 20% of the water and 7% of the salts
  6. Tubular reabsorption a. DCT reabsorbs Na+, Cl-, water b. CD reabsorbs water
  7. Tubular secretion - DCT and CD secrete H+, K+, NH 4 +
  8. Aldosterone โ€“ stimulates DCT and CD to reabsorb more Na+^ and secrete K+, water and Cl-^ follow the Na+
  9. ANP โ€“ inhibits NaCl reabsorption by the CD and inhibits renin, aldosterone, and ADH secretion
  10. ADH โ€“ increases CD permeability to water ----Glucose, Amino Acids, Protein, Vitamins, Lactate, Urea, Uric acid, Na+, K+, Ca, Mg, Cl, ChO 3 -, H 2 O -------At the PCT ------------------ In - H 2 O, Urea โ€“ secretion-----------Na, K+, Cl-, ---DCT----- Na+ Cl- HCO 3 -----------, H 2 O (resabsoprtion), Na+, Cl, HCO 3 ------- HK, NH 4 -------------into collecting duct------Water + Urea into the tube----- figure 23.20 for FULL DETAILS Tubular Reabsorption Tubular Secretion In which part of the tubule we have sodium secrete/absorption? Can you tell me which ones? KNOW THIS DIAGRAM ๏Œ - (multiple choice ๏Š) โ€“ 5 questionsโ€ฆish. V. Urine A. Properties of urine
  11. Color โ€“
  12. Clear โ€“
  13. Odor โ€“ upon standing bacteria degrades urea to ammonia
  14. pH โ€“ 4.5-8.
  15. Chemical composition โ€“ 95% water, urea, NaCl, KCl, creatinine, uric acid, etc. B. Urine volume
  16. Polyuria โ€“
  1. Oliguria โ€“
  2. Anuria โ€“ 0-100 mL / day
  3. Diuretic โ€“ a. Caffeine โ€“ b. Alcohol โ€“ inhibits ADH secretion c. Lasix โ€“ inhibits sodium reabsorption d. Glucose โ€“ in diabetics it acts as a diuretic by requiring water for its excretion VI. Other urinary structures and elimination A. Ureters (Fig. 23.23, pg. 932)
  4. Open onto the floor of the urinary bladder
  5. Urine moves through the ureters by peristalsis B. Urinary bladder (Fig. 23.23, pg. 932)
  6. Mucosa has transitional epithelium that thins from 5-6 layers to 2- layers as bladder fills
  7. Rugae โ€“ wrinkles in mucosa when relaxed (empty)
  8. Trigone โ€“ triangle marked by openings of ureters and urethra C. Urethra (Fig. 23.23, pg. 932)
  9. Female - 3-4 cm long, male โ€“ 18 cm long
  10. Internal urethral sphincter retains urine in bladder
  11. External urethral sphincter provides voluntary control over urination D. Urination (voiding, micturition) (Fig. 23.24, pg. 934)
  12. When the urinary bladder is filled to 200 mL or more it excites stretch receptors
  13. Stretch receptors in bladder wall transmit signals to the CNS
  14. Signals from the CNS relax the internal urethral sphincter and excite detrusor muscles to contract
  15. The external urethral sphincter is voluntarily relaxed E. Urinary problems
  16. Kidney stones โ€“ hard granules of calcium, phosphate, uric acid, and protein
  17. Urinary tract infection โ€“
  18. Acute glomerulonephritis โ€“ autoimmune disease causing inflammation of the glomeruli
  19. Renal failure โ€“ decline in renal function due to damage or loss of nephrons
  20. Urinary incontinence โ€“ inability to hold urine
  21. Hydronephrosis โ€“ increase in fluid pressure in the renal pelvis and calyces from obstruction of the ureter