Malignant Tumors of Kidney, Study Guides, Projects, Research of Medical Sciences

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Malignant Tumors of Kidney I- Wilm's tumour (Embryoma or Nephroblastoma) II- Renal cell carcinoma (Hypernephroma) * Incidence : 1- 10% of childhood malignancy 2- Usually below 4 years. 3- More in males. 4- May be bilateral in 10% . 1- 80% of renal tumours. 2- Usually above 40 years. 3- More in males. 4- Bilateral (2%) * Predisposing Factors : 1-Use of tobacco products . 2- Defect in chromosome 3 3-Von Hipple-Lindau disease ( renal & pancreatic cyst , cerebellar haemangio- blastoma , retinal angioma & pheochromocytoma ) * Pathology : Arise from embryonic 1- Origin: = From the epithelium of the nephrogenic multipotent . proximal convoluted mesodermal cells. tubules. 2- Site: = In one pole of the kidney, usually the upper pole. 3-Gross picture = Large smooth mass infiltrates & destroys the renal parenchyma > early loss of renal function = The pelvicalyceal system resists and becomes stretched and compressed > haematuria is late. = A mass variable in size. Compresses the renal parenchyma late loss of renal functions * Early infiltration of the pelvicalyceal system and early haematuria.