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A comprehensive overview of the mechanism of allograft rejection, a complex process involving the immune system's response to transplanted organs or tissues. It delves into the different types of transplants, the immunologic basis of rejection, and the various mechanisms involved, including cell-mediated immunity, humoral immunity, and the role of nk cells. The document also explores the classification of allograft rejection, including hyperacute, acute, and chronic rejection, and discusses the graft versus host reaction (gvhr) that can occur after bone marrow transplantation. Finally, it outlines prevention and therapy strategies for allograft rejection, emphasizing the importance of tissue typing and immunosuppressive therapy.
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Transplantation:
donor site. Organ donors can be living or deceased Organs that can be transplanted:
Tissues that can be transplanted:
Immunologic Basis of Allograft Rejection Grafts rejection
I. Major histocompatibility antigens (MHC molecules)
Humoral immunity
Classification of Allograft Rejection
Host versus graft reaction (HVGR)
**1. Hyperacute rejection
Acute rejection
Chronic rejection
Prevention and Therapy of Allograft Rejection