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Information on three medications used to reduce or prevent postpartum bleeding: oxytocin (pitocin), misoprostol (cytotec), and methylergonovine (methergine). For each medication, the document lists the name, purpose, safe dosage, side effects, and patient education. Nurses can use this list to make clinical judgments about medication administration and monitor clients for adverse reactions.
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List specific findings (assessments/cues, VS, labs, etc.) that support the need for this medication.
Medication name
Purpose of the medication for THIS client
How will the nurse know there is a problem, or the client is not tolerating the medication?
How will the nurse know the medication is effective? Patient/ Family Education
oxytocin (synthetic injection)
TRADE: Pitocin
CLASSIFICATION: Therapeutic class: Oxytocic Pharmacologic class: Exogenous hormones
Is the dose safe? YES
To reduce postpartum bleeding after expulsion of placenta Adults: 10 to 40 units IV infused at rate needed to sustain uterine contraction and control uterine atony. Also, may give 10 units IM after delivery of placenta
Monitor fluid intake and output. Antidiuretic effect may lead to fluid overload, seizures, and coma from water intoxication. Increase amount of bleeding
Reduces amount of bleeding
Instruct patient to promptly report adverse reactions (site irritation, nausea, bleeding, blurred vision, difficulty speaking, wheezing, itching, swelling)
Misoprostol
TRADE: Cytotec CLASSIFICATION: Therapeutic class: Antiulcer drugs Pharmacologic class: Prostaglandin E1 analogues
Is the dose safe? NO
To prevent NSAID- induced gastric ulcer in patients at high risk for complications from gastric ulcer and in patients with history of NSAID-induced ulcer Misoprostol is another prostaglandin that increases uterine tone and decreases postpartum bleeding. Misoprostol is effective in the treatment of postpartum
Associated side effects may include shivering and fever Vaginal bleeding or spotting may occur
Postpartum hemorrhage should decrease within minutes of use
Remind female patient who is pregnant that drug may cause miscarriage, premature birth, or birth defects, often with potentially life-threatening bleeding
List specific findings (assessments/cues, VS, labs, etc.) that support the need for this medication.
Medication name
Purpose of the medication for THIS client
How will the nurse know there is a problem, or the client is not tolerating the medication?
How will the nurse know the medication is effective? Patient/ Family Education
hemorrhage, but side effects may limit its use. It can be administered sublingually, orally, vaginally, and rectally
Methylergonovine
TRADE: METHERGINE CLASSIFICATION: Ergot alkaloids
Is the dose safe? NO
It is used to stop or treat bleeding that happens after a birth.
Increased amount of bleeding with use
Prevention/ Reduction of postpartum bleeding
It works by increasing the rate and strength of contractions and the stiffness of the uterus muscles. These effects help to decrease bleeding. Do not drive, use machinery, or do anything that needs alertness until you can do it safely Do not breast-feed within 12 hours after taking methylergonovine. Methylergonovine may pass into breast milk in small amounts and could affect a nursing baby.
GENERIC:
TRADE:
CLASSIFICATION:
Is the dose safe?