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This document serves as a final study guide for mn650, covering key pharmacological concepts and clinical considerations relevant to medication management. It includes information on various medications, their mechanisms of action, potential adverse effects, and important monitoring parameters. The guide emphasizes practical knowledge for healthcare professionals, such as understanding drug interactions, managing specific conditions like diabetes and hypertension, and addressing special populations like older adults. It also covers essential topics like antibiotic resistance, appropriate antibiotic use, and the management of common infections and chronic diseases. This study guide is designed to help students and practitioners consolidate their understanding of pharmacology and apply it effectively in clinical practice. (447 characters)
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Ginseng - Answer Modulates blood glucose levels by improving β-cell function and enhancing insulin sensitivity Saw palmetto - Answer Utilized for improving urinary production/health, especially with BPH Valerian tea - Answer Used for relaxation Antibiotics - Answer Needed promptly for immunocompromised patients such as diabetics and HIV/AIDS patients, and those who sustained a human/animal bite Alternative ABX treatments - Answer Used for PCN allergy when a patient has an animal bite Animal bite care - Answer Includes thorough cleaning and possible debridement Organism of animal bites - Answer Includes Pasteurella, Fusobacterium, Streptococci aureus, etc. Appropriate response to sepsis - Answer Includes crystalloid fluids and appropriate use of antibiotics Common STI treatment - Answer Includes Herpes, Gonorrhea, Chlamydia Beta blockers - Answer May cause bradycardia if over prescribed, especially in those on HTN therapy or taken as an ophthalmic solution Heparin drug monitoring - Answer Includes ptt/pt; Serial anti-factor Xa assessment for dose adjustment should be considered for all pregnant women receiving low molecular weight heparin INR level - Answer Best time to draw for patients on coumadin is usually in the morning in the hospital for dose adjustments Higher doses of coumadin - Answer May be required in certain populations, even though the usual starting dose is 5mg Aspirin toxicity symptoms - Answer Should be understood Simultaneous use of coumadin and heparin - Answer Done in the hospital setting, important to understand and educate patients Antibiogram - Answer Used to understand antibiotic resistance patterns Vitamin B6 supplementation - Answer Necessary during isoniazid (INH) therapy to
prevent peripheral neuropathy Antifungal medications - Answer Can cause hepatotoxicity, monitor relevant labs Antibiotics interfering with birth control - Answer Should be understood, along with management strategies NSAID and aspirin adverse effects - Answer Should be understood, especially when used with other medications Medications for stomach ulcers and heartburn - Answer Should be understood Prednisone tapering - Answer Doses over 40mg are tapered, not abruptly discontinued, to protect adrenal function and cortisol secretion Dosing of oral and parental glucocorticoids - Answer Is equivalent due to rapid and complete absorption in the GI tract Appropriate treatment for uncomplicated UTI - Answer Should be understood, along with identifying who will benefit from this treatment ABX and interference with antiseizure medications - Answer Should be understood Lithium toxicity - Answer Includes tremors, nausea, visual changes, mental status changes, vomiting; commonly prescribed for certain mental health issues Beta blockers and hypoglycemia symptoms - Answer May cause and alter symptoms like hypoglycemia Creatine clearance level - Answer Should be understood Tapering of beta blockers - Answer Should be done gradually, taper by half Ace inhibitors - Answer Prescribed for renal protection in diabetics with HTN, but may cause renal function decline and may need to be tapered Outcome of long-term use of PPI's - Answer Should be understood Prescribing considerations in older adults - Answer Should be understood Geriatric pharmacodynamics/pharmacokinetics - Answer Drugs may last longer and cause toxicity Hyperkalemia treatment - Answer Includes urgent treatment and non-emergent treatment Potassium levels with metabolic alkalosis - Answer Should be understood Calculation of corrected calcium - Answer Corrected calcium = serum calcium + 0.8 (4 - serum albumin)