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Nanomilling is a proven and scalable method to prepare small particle size drug particles, which significantly increases their dissolution rate and solubility. This process is essential for improving the bioavailability and efficacy of drugs, especially those with low solubility. Cd formulation offers nanomilling services for the development of nanoparticle suspensions, providing a sterile environment and expertise in the field.
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Low dissolution rate and solubility seriously affect the bioavailability and efficacy of the drug, and are the primary factors that cause the drug development candidate compound to fail to become a drug. It is found through research that when the particle size is reduced to a certain extent (100~200 nm), its dissolution rate and solubility will increase significantly. Nanomilling method is an effective, repeatable and scalable method, which can effectively improve the bioavailability and efficacy of drugs. Fig .1 Nanomilling process from original solid to nanomilled solid CD Formulation has professional experience and technical personnel in the development of nanoparticle suspensions. Thanks to the very complete experimental equipment, we can perform nanomilling under aseptic conditions. If you choose to advance your nanomilling project, we have the personnel, facilities and equipment to produce clinical and commercial scale nanomilling formulations. If you have an insoluble API, please contact us
below to learn how nanomilling can help solve your formulation challenges and let us move your product from concept to commercialization.
As a qualified pharmaceutical preparation R&D supplier, our team has very professional pharmacy and related professionals. Our laboratory equipment meets the requirements of drug development. At the same time, we have a laboratory that provides a sterile environment to facilitate the nanomilling of drugs. Our nanomilling is mainly divided into the following steps:
Nanomilling is a proven, commercially validated process that can be used to formulate almost all poorly water-soluble APIs. The key to nanomilling is to reduce the particle size, which increases the surface area of the API and improves the dissolution rate. Compared with other solubilization methods, nanomilling has key advantages, including: