Docsity
Docsity

Prepare for your exams
Prepare for your exams

Study with the several resources on Docsity


Earn points to download
Earn points to download

Earn points by helping other students or get them with a premium plan


Guidelines and tips
Guidelines and tips

Neoplasia Nomenclature and Cancer Pathogenesis, Study Guides, Projects, Research of Medical Sciences

Information on the nomenclature of different types of tumors, including mixed tumors, teratomas, choristomas, and hamartomas. It also discusses the differentiation between benign and malignant cells, dysplasia, and carcinoma in situ. The document further explains the molecular basis of multistep carcinogenesis, tumor cell kinetics, tumor angiogenesis, mechanisms of invasion and metastasis, chemical carcinogenesis, immunosurveillance, grading and staging of tumors, and laboratory diagnosis of cancer using histologic and immunohistochemistry methods.

Typology: Study Guides, Projects, Research

2022/2023

Available from 02/11/2023

professor_x
professor_x 🇮🇳

238 documents

1 / 63

Toggle sidebar

This page cannot be seen from the preview

Don't miss anything!

bg1
NEOPLASIA
pf3
pf4
pf5
pf8
pf9
pfa
pfd
pfe
pff
pf12
pf13
pf14
pf15
pf16
pf17
pf18
pf19
pf1a
pf1b
pf1c
pf1d
pf1e
pf1f
pf20
pf21
pf22
pf23
pf24
pf25
pf26
pf27
pf28
pf29
pf2a
pf2b
pf2c
pf2d
pf2e
pf2f
pf30
pf31
pf32
pf33
pf34
pf35
pf36
pf37
pf38
pf39
pf3a
pf3b
pf3c
pf3d
pf3e
pf3f

Partial preview of the text

Download Neoplasia Nomenclature and Cancer Pathogenesis and more Study Guides, Projects, Research Medical Sciences in PDF only on Docsity!

NEOPLASIA

NOMENCLATURE

 All tumors have 2 basic

components:

1. The “transformed”

neoplastic cells

2. The supporting stroma

Some tumors appear to have more

than 1 parenchymal cell types:

1. Mixed Tumors

2. Teratomas

Mixed Tumor

Derived from 1 germ cell layer that

differentiates into more than 1

parenchymal cell type.

Ex: Mixed Salivary Gland Tumor

contains epithelial cells as well as myxoid

stroma & cartilage–like tissue. All elements

arise from altered differentiation of ductal

epithelial cells

Teratomas

Made up of a variety of parenchymal cell

types representative of more than 1 germ

cell layer, usually all 3.

They arise from totipotential cells that

retain the ability to form endodermal,

ectodermal, & mesenchymal tissues.

Such tumors are principally in the testis &

ovary.

Teratomas

Choristoma

Ectopic, sometimes nodular, rests of

nontransformed tissues.

Ex: Pancreatic cells under the small

bowel mucosa

Choristoma

Hamartomas of the Lung

Characteristic Benign Malignant

  1. Differentiation Closely mimic corresponding normal cells a. Nuclear & Cellular Pleomorphism b. Hyperchromatism c. Nuclear-cytoplasmic Ratio = 1: d. Abundant Abnormal Mitotic Figures e. Tumor Giant Cells f. Presence of Nucleolus
  2. Rate of Growth Mostly slow- growing Mostly expand rapidly
  3. Local Invasion Expansile growth & do not breach capsule Invasive , infiltrating, & destroying surrounding normal tissues
  4. Metastasis No Yes

Differentiation

Histology Benign

Differentiation

Histology Malignant

Differentiation

Benign Malignant

MALIGNANT CELL ATLAS

SLIDES # 12 - 17