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Neurons and Glia, Lecture notes of Neuroanatomy

An overview of the features of neurons and glia. It discusses the morphology of neurons, their membrane composition, and the different zones of a neuron. It also covers the cytoskeleton, the classification of neurons, and the role of glial cells in supporting neurons. useful for students studying neuroscience or related fields.

Typology: Lecture notes

2020/2021

Available from 01/13/2022

nick-barber
nick-barber 🇺🇸

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Neurons and glia
What are the features of a neuron?
- Morphological diversity that accomondate for many different functions
- Create electrical signals due to specialied electric properties
- Specialized for intercellular communication
Zones of a neuron
Dendrites & soma=input zone
axon=conducting zone
Axon terminals = output zone
What are the features of a neuron’s membrane?
- ~ 5 nm thick
- A barrier enclosing cytoplasm inside neuron and excluding substances in neuron’s
external environment
- Composition varies at different locations of neuron
- Some membrane proteins push substances from inside to the outside, others create pores
to regulate substances that enter
What are the features of the cytoskeleton?
- Elements of cytoskeleton are regulated and constantly in motion
- Microtubules: big and run down neurites
- Neurofilaments: intermediate in size, function as space filling structures that contribute to
axon diameter
- Microfilaments: make two thin actin strands stuck to the membrane, and involved in
changing the cell’s shape.
What are the features of the input zone of a neuron?
Soma:
- Cell body, contain essential organelles, specifically ribosomes
- Dendrites receive information
Dendritic spines
- A storage site for synapse strength
- Help move electrical signals to soma
- Involved in many neurodevelopmental disorders
What are the features of the conductance zone?
Axon
- Key structure for transferring information at a distance, highly specialized
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Neurons and glia

What are the features of a neuron?

  • Morphological diversity that accomondate for many different functions
  • Create electrical signals due to specialied electric properties
  • Specialized for intercellular communication Zones of a neuron Dendrites & soma=input zone axon=conducting zone Axon terminals = output zone What are the features of a neuron’s membrane?
  • ~ 5 nm thick
  • A barrier enclosing cytoplasm inside neuron and excluding substances in neuron’s external environment
  • Composition varies at different locations of neuron
  • Some membrane proteins push substances from inside to the outside, others create pores to regulate substances that enter What are the features of the cytoskeleton?
  • Elements of cytoskeleton are regulated and constantly in motion
  • Microtubules: big and run down neurites
  • Neurofilaments: intermediate in size, function as space filling structures that contribute to axon diameter
  • Microfilaments: make two thin actin strands stuck to the membrane, and involved in changing the cell’s shape. What are the features of the input zone of a neuron? Soma:
  • Cell body, contain essential organelles, specifically ribosomes
  • Dendrites receive information Dendritic spines
  • A storage site for synapse strength
  • Help move electrical signals to soma
  • Involved in many neurodevelopmental disorders What are the features of the conductance zone? Axon
  • Key structure for transferring information at a distance, highly specialized
  • Begins at the region called the axon hillock: begins at the soma and form the initial segment of the axon
  • Difference from the soma = membrane composition -> translates into different functionality
  • Few ribosomes -> no protein synthesis What are the features of the output zone?
  • Axon ends at axon terminal (or terminal bouton)
  • At the terminal, axon comes into contact with neurons forming synapses
  • The collection of branches are called terminal arbor
  • Each branch forms a synapse with a dendrite or soma of another neuron
  • When a neuron makes sypase contact with another neuron, it is innervating that neuron What is grey matter? neuronal cell body (cortex) What is white matter? myelination (axons) Neurons can be classified by:
  • Structure
  • Genetic expression

What do glial cells do?

Support neurons electrical and chemical needs

  • Metabolic support
  • Insulation
  • immune /scar tissue
  • Circuit formation/synaptic plasticity
  • Form blood brain barrier What are features of astrocytes?
  • Found in grey and white matter
  • role in in extracellular homeostasis
  • role in synaptogenesis and neurogenesis
  • Take-up and process neurotransmitters from the synaptic cleft
  • Key in formation of the blood brain barrier (BBB)
  • Role in formation of scar tissue following neuronal injury
  • Vulnerable to flavivirus What is a subtype of astrocyte? glial stem cells What are their features?
  • found near the ventricles, typically close to blood vessels
  • Similar properties to somatic stem cells
  • can give rise to: