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NURS 660 Exam 4 Questions: Pharmacology and Neurobiology of ADHD and Substance Abuse, Exams of Nursing

Maryville University of Saint LouisNursing

A comprehensive set of questions and answers related to the pharmacology and neurobiology of adhd and substance abuse. It covers various aspects of these topics, including medication contraindications, mechanisms of action, side effects, and brain regions involved in these conditions. Particularly useful for students in nursing or related healthcare fields who are studying these topics.

Typology: Exams

2024/2025

Available from 01/06/2025

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NURS 660 EXAM 4 QUESTIONS
FULLY SOLVED & UPDATED.
1) Which medication is contraindicated with liver impairment? --
Answer ✔✔ Atomoxine (Strattera)
2) What is one of the birth defects associated with Lithium? --
Answer ✔✔ Ebstein's anomaly
3) Which SSRI drug causes cardiovascular malformations in the first
trimester of pregnancy? -- Answer ✔✔ Paroxetine (Paxil)
4) Mechanism of action of a stimulant for ADHD Methylphenidate
and amphetamine? -- Answer ✔✔ increases the intrasynaptic
levels of both dopamine and norepinephrine
5) What causes nicotine withdrawal symptoms? -- Answer ✔✔
Nicotine alpha 4 beta 2 post synaptic receptors desensitizes
receptors which leads to addiction. Re-sensitization of the nicotine
receptors leads to withdrawal
6) A patient diagnosed with ADHD can't stay focused or solve work-
related problems difficulty maintaining attention sustained and
problem-solving. What area of the brain is involved? -- Answer ✔✔
Dorsal lateral prefrontal cortex (CTSC loop)
7) What part of the brain is associated with selective attention? --
Answer ✔✔ Dorsal anterior singlunate
8) What part of the brain is associated with hyperactivity? -- Answer
✔✔ Prefrontal motor cortex
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Download NURS 660 Exam 4 Questions: Pharmacology and Neurobiology of ADHD and Substance Abuse and more Exams Nursing in PDF only on Docsity!

NURS 660 EXAM 4 QUESTIONS

FULLY SOLVED & UPDATED.

  1. Which medication is contraindicated with liver impairment? -- Answer ✔✔ Atomoxine (Strattera)
  2. What is one of the birth defects associated with Lithium? -- Answer ✔✔ Ebstein's anomaly
  3. Which SSRI drug causes cardiovascular malformations in the first trimester of pregnancy? -- Answer ✔✔ Paroxetine (Paxil)
  4. Mechanism of action of a stimulant for ADHD Methylphenidate and amphetamine? -- Answer ✔✔ increases the intrasynaptic levels of both dopamine and norepinephrine
  5. What causes nicotine withdrawal symptoms? -- Answer ✔✔ Nicotine alpha 4 beta 2 post synaptic receptors desensitizes receptors which leads to addiction. Re-sensitization of the nicotine receptors leads to withdrawal
  6. A patient diagnosed with ADHD can't stay focused or solve work- related problems difficulty maintaining attention sustained and problem-solving. What area of the brain is involved? -- Answer ✔✔ Dorsal lateral prefrontal cortex (CTSC loop)
  7. What part of the brain is associated with selective attention? -- Answer ✔✔ Dorsal anterior singlunate
  8. What part of the brain is associated with hyperactivity? -- Answer ✔✔ Prefrontal motor cortex
  1. What part of the brain is associated with impulsivity? -- Answer ✔✔ Orbitofrontal cortex 10)Atomoxetine (Strattera) lacks abuse potential because of what -- Answer ✔✔ increases dopamine in the dorsal prefrontal cortex and not in the nucleus accumbens 11)What fetal malformation does valproate cause? -- Answer ✔✔ Spina bifida 12)What region of the brain is hypothesized to cause impulsivity? -- Answer ✔✔ ventral striatum 13)What region of the brain controls compulsivity? -- Answer ✔✔ Dorsal striatum 14)What is the MOA of atomoxetine (Strattera)? -- Answer ✔✔ Selective Norepinephrine Reuptake Inhibitor: Boosts neurotransmitter norepinephrine/ noradrenaline and may also increase dopamine in prefrontal cortex • Blocks norepinephrine reuptake pumps, also known as norepinephrine transporters • 15)Amaloid precursor protein is first cleaved by what enzyme -- Answer ✔✔ Alpha-secretase 16)What does paroxetine do to Strattera in the body? -- Answer ✔✔ increases the effect of the drug in the body 17)If a patient is taking paroxetine and starts Strattera what should change about the Strattera dose? -- Answer ✔✔ The dose should be decreased 18)An Alzheimer's patient has been taking 4mg of rivastigmine what side effects might you anticipate and why? -- Answer ✔✔ GI side effects; inhibits peripheral uptake of ACH and butyrylcholine

29)Pleasure center pathway of the brain? Links to addiction -- Answer ✔✔ histaminergic mechanisms and increases dopamine binding to dopamine receptor 30)17 y/o girl had ADHD can't complete assignments or pay attention to what area of the cortex regulates this? -- Answer ✔✔ anterior cingulate cortex 31)Modafinil what does it treat? -- Answer ✔✔ narcolepsy and depression 32)Medication that is an NMDA receptor Antagonist -- Answer ✔✔ Memantine 33)Women present with ETOH disorder multiple drinks daily children have been removed wants to stop cold turkey but had w/d symptoms is she a good candidate for reduced drinking as a goal? -- Answer ✔✔ No. Reduced-risk drinking as a goal is controversial. However, some patients will not agree to abstinence as a goal. For these patients, it can still be beneficial to work with them to reduce their drinking. 34)What are the biomarkers indicative of Alzheimer's disease? Which is elevated and which is decreased? -- Answer ✔✔ Decreased cerebrospinal fluid (CSF) levels of amyloid beta and increased CSF levels of tau protein 35)An athlete has natural HIGH what part of the brain is stimulated? Dopamine increase where? -- Answer ✔✔ Amygdala mesolimbic pathway 36)What is the treatment for a Vicodin OD? -- Answer ✔✔ Narcan 37)What does alcohol do in the ventral tegmental part of the brain? -- Answer ✔✔ causes release of endogenous opioids, inhibits

glutamate release, enhances GABA release by blocking presynaptic GABA b receptors 38)What two neurotransmitters are affected by alcohol? What is increased what is decreased? -- Answer ✔✔ GABA and Glutamate. Increase GABA and decreases glutamate. 39)What role does the amygdala play in substance abuse? -- Answer ✔✔ Communicates to the VTA when cues related to drugs of abuse are present. 40)Which a lipoprotein Genotype that predicts a faster progression of mild cognitive impairment to Alzheimer's to dementia? -- Answer ✔✔ APEO 41)Someone wants to quit smoking what receptors reinforce these effects why you can't stop? What area of the brain is the alpha postsynaptic receptor? -- Answer ✔✔ Alpha 4 beta 2 postsynaptic receptors in the VTA. 42)Someone tried MDMDA at a party. What is the key binding site for this hallucinogen? -- Answer ✔✔ serotonin 2a 43)Child on stimulant what is black box warning for pediatric population? -- Answer ✔✔ cardiovascular; ECG prior to starting therapy with Ritalin (methylphenidate). 44)The most common adverse side effect of Donepezil? -- Answer ✔✔ GI side effects 45)MOA of Amantadine -- Answer ✔✔ Symmetrel: The mechanism of action in PD is poorly understood but animal studies suggest either that it induces release or decreases reuptake of dopamine.