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A comprehensive overview of cell biology, focusing on the structure and function of various cellular components, including organelles, membranes, and transport mechanisms. It delves into the processes of passive and active transport, highlighting key concepts like diffusion, facilitated diffusion, and active transport. The document also includes examples of specific transport proteins and their roles in maintaining cellular homeostasis.
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Mitochondria - ANSWER Site of aerobic respiration (power house) Peroxisome -by self replication ANSWER Break down of fatty acids, and synthesis of cholesterol. Form
Endoplasmic reticulum -apparatus ANSWER Transport of synthesized proteins to the Golgi
Lysosome -Form by breaking off from Golgi apparatus and dispersing throughout cytoplasm ANSWER Contain hydrolytic enzymes involved in intracellular digestion.
Golgi apparatus -repackages them into vesicles, and distributes them vis exocytosis ANSWER Receives vesicles from smooth ER, modifies them,
Centrioles -cell division ANSWER Specialized micro tubule involved in spindle organization during
Ribosomes -molecules in the cell ANSWER Made up of RNA and proteins. Synthesize new protein
Smooth ER - ANSWER Lipid synthesis Cytoskeleton -structure for certain parts of the cell ANSWER Filament and tubular structures to act as a rigid physical
Cell membrane -Chemical and Physical Barrier (impermeable), Allows cell communication, Regulate ANSWER Separates ICF from ECF, Maintain the cell structure,
water and solute exchange (semipermeable) Inclusions -crystals ANSWER Granules of glycogen or pigments, lipid droplets, vacuoles,and
Peripheral proteins -or as controllers of transport through membrane pores. ANSWER Attached to integral proteins and function as enzymes
Glycocalyx - ANSWER Loose carbohydrate coat on entire outside surface of the cell Simple diffusion - ANSWER Nonpolar lipid‐soluble (hydrophobic) substances diffuse directly through the phospholipid bilayer Facilitated diffusion -membranes through protein channels ANSWER Movement of specific molecules across cell
Pores - ANSWER Non gated channels Porins - ANSWER In the outer membrane of mitochondria Perforin -molecules. ANSWER released by lymphocytes, allows passive flow ofions, water, small
Aquaporin - ANSWER single‐file diffusion of water. Channel-mediated - ANSWER Facilitated diffusion Un-gated or leakage channels -distribution of charge, etc ANSWER Always open. Determined by size, shape,
cytoplasm (organelles) Nucleus Membranous Organelles - ANSWER Mitochondria PeroxisomesER Lysosomes Golgi Nonmembranous Organelles - ANSWER Cytoskeleton CentriolesRibosomes
Cellular Membrane -constantly changing fluid mosaic ANSWER asymmetric bimolecular layer of lipids and proteins in a
Phospholipids -Heads- polar & hydrophilic ANSWER 75% lipids; amphipatic Tails - Nonpolar & hydrophobic glycolipids -surface ANSWER 5% of lipids; have polar sugar groups on outer membrane
Cholesterol - ANSWER 20% of lipids; increases membrane stability (non-flexible) Integral Proteins - ANSWER adhesion molecules transport proteins enzymes
receptors intracellular signaling peripheral proteins -glycoproteins on extracellular surface ANSWER supportive filaments on intracellular surface and
Membranes are impermeable to... - ANSWER charged and water-soluble molecules determinants of passive membrane transport -composition of lipid bilayer, membrane thickness, conc. gradient, membrane surface ANSWER lipid solubility, molecular size, area simple diffusion -phospholipid bilayer ANSWER hydrophobic substances diffuse directly through
lonopores -that dissolve in lipid bilayers and increase permeability to specific inorganic ions ANSWER Present in Facilitated Diffusion. They are hydrophobic molecules
porins - ANSWER Simple diffusion: located in outer membranes of mitochondria perforin -water, small molecules ANSWER simple diffusion: released by lymphocytes, allows flow of ions,
aquaporin - ANSWER simple diffusion: single-file diffusion of water channel mediated facilitated diffusion - ANSWER ungated- always open gated - controlled by chemical or electrical signals carrier mediated facilitated diffusion -change in carrier ANSWER substrate binding causes shape
Glycosides - ANSWER inhibit Na/K ATPase increase intracellular Na+increase intracelular Ca2+ can cause heart failure Vesicular Transport - ANSWER transport of LARGE particles, requires ATP Phagocytosis - ANSWER Endocytosis. Psudopods engulf solids. Phagosome is combined w/ Lysosome (phagolysosome) undigested contents remain or are ejected by exocytosis receptor-mediated endocytosis -close ANSWER CLATHRIN COATED PITS - make vesicle uptake of ligands all vesicles used get recycled Pinocytosis -solutes inside ANSWER plasma membrane infolds to bring extracellular fluid and -typical in small intestine