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A concise question-and-answer review of various medications and their uses, focusing on pharmacology. It covers topics such as migraine and tension headaches, alcohol and opioid withdrawal treatments, gout management, and fibromyalgia medications. The document also addresses specific drug mechanisms, contraindications, and black box warnings, making it a valuable resource for medical students or healthcare professionals studying or reviewing pharmacology concepts. It includes key points about drug actions, side effects, and management strategies for various conditions. This material is useful for exam preparation and quick reference.
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Describe a migraine headache - ✔✔Unilateral, throbbing, pulsatile, lasts 4 - 72 hours, includes nausea and vomiting, light sensitivity, may have auras, more common in women, and genetically linked. There are migraine variants that include focal neurologic findings Describe a tension headache - ✔✔Most common headache; treated effectively with NSAIDs Describe a cluster headache - ✔✔"Ice pick headache", unilateral, severe pain behind one eye, nasal congestion with rhinorrhea, occur in clusters over weeks to months, often at night, more common in men and blacks Describe a rebound headache - ✔✔Occur due to overuse of medications to treat headache pain. The medication causes worsening of the pain. Treatment entails discontinuing all pain medications What medications are used for abortive treatment of migraines? - ✔✔Triptans, Ergots, analgesics, NSAIDs, antiemetics, combination products What are the indications for prophylactic migraine treatment? - ✔✔>2 headaches per month, attacks last >24 hours, cause major disruption in ADLs for 3+ days a month, abortive therapies fail or are overused, use of abortive medications 2x+ per week What medications are used for prophylactic treatment of migraines? - ✔✔TCAs, BBLs, triptans, AEDs (Divalproex) Describe Serotonin 1B/1D receptor agonists - ✔✔- Sumatriptan (Imitrex)
Describe ergot alkaloids - ✔✔- Ergotamine