Midterms
Angel Javier | PIP | SEM 01 2022
1
DEFINITION OF TERMS
Pharmaceutics
- is the study of the preparations of drug
dosage forms and drug delivery systems
with their use in patient care.
- It is a branch of pharmacy that includes the
study of formulation of drugs into dosage
forms.
- It provides the knowledge of
interrelationship between physical
pharmacy, biopharmaceutics,
pharmacokinetics, dosage form design,
formulation, small and large scale
manufacture and the clinical application of
dosage forms in patient care.
Drug
- is an agent used for the diagnosis,
mitigation, treatment, cure or prevention of
diseases in humans or animals. Dosage
forms
- Barium enema for radiocontrast media
Dosage Form
- are the means through which drugs are
delivered in the body towards its site of
action.
- They are the final product containing drugs
that are administered to the patients.
-Dosage forms (medicine) include/consist
of active drug ingredients and
pharmaceutical excipients.
API - gives therapeutic effect on body; main
ingredient
Excipients - cannot be seen on the generic name
but are in the medicine; used as a bulky ingredient;
starch, lubricants
IMPORTANCE OF DIFFERENT DOSAGE FORMS
1. To provide accurate dose
2. To deliver in a convenient form to the patient
3. To Increase the stability of the drug
- Medications are more stable if there
is no water in the ingredient because
water permits or promotes the
growth of microbial microorganisms
- Drugs last for 7 days in room
temperature and 14 days in
refrigerator
4. To enhance therapeutic activity of the drug
substance
THE NEED FOR DOSAGE FORMS
Besides providing the mechanism for the safe and
convenient delivery of accurate dosage,
pharmaceutical dosage forms are needed for the
following additional reasons:
1. To provide drug products that bypass the
first-pass metabolism
- When the drug arrived at the liver
where it will be metabolized, first
pass effect will occur; usually, orally
administered medicines will undergo
first pass metabolism
- LADMER (liberation, absorption,
distribution, metabolism, elimination,
and response)
- e.g., injections, topical dosage forms
etc.
2. To protect the drug substance from the
destructive influence of atmospheric oxygen
or humidity
- e.g., coated tablets.
