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FPGEE like questions on sulfonamides, Quizzes of Pharmacology

Contains 10 questions related to sulfonamides - can be asked in any competitive exams like gpat

Typology: Quizzes

2024/2025

Available from 05/02/2025

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1. Which of the following is the primary mechanism of action of sulphonamides?
A. Inhibition of bacterial DNA gyrase
B. Inhibition of folic acid synthesis
C. Inhibition of bacterial cell wall synthesis
D. Disruption of bacterial cell membrane
Answer: B. Inhibition of folic acid synthesis
2. Sulphonamides are structurally similar to which compound, allowing them to act as
competitive inhibitors?
A. PABA (para-aminobenzoic acid)
B. Folic acid
C. Thymidine
D. Dihydrofolate
Answer: A. PABA (para-aminobenzoic acid)
3. Which of the following sulphonamides is commonly used in combination with trimethoprim?
A. Sulfisoxazole
B. Sulfadiazine
C. Sulfamethoxazole
D. Sulfacetamide
Answer: C. Sulfamethoxazole
4. The combination of sulfamethoxazole and trimethoprim is known as:
A. Augmentin
B. Bactrim
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  1. Which of the following is the primary mechanism of action of sulphonamides? A. Inhibition of bacterial DNA gyrase B. Inhibition of folic acid synthesis C. Inhibition of bacterial cell wall synthesis D. Disruption of bacterial cell membrane Answer: B. Inhibition of folic acid synthesis
  2. Sulphonamides are structurally similar to which compound, allowing them to act as competitive inhibitors? A. PABA (para-aminobenzoic acid) B. Folic acid C. Thymidine D. Dihydrofolate Answer: A. PABA (para-aminobenzoic acid)
  3. Which of the following sulphonamides is commonly used in combination with trimethoprim? A. Sulfisoxazole B. Sulfadiazine C. Sulfamethoxazole D. Sulfacetamide Answer: C. Sulfamethoxazole
  4. The combination of sulfamethoxazole and trimethoprim is known as: A. Augmentin B. Bactrim

C. Zosyn D. Keflex Answer: B. Bactrim

  1. Which of the following is NOT a common adverse effect of sulphonamides? A. Stevens-Johnson syndrome B. Crystalluria C. Hypersensitivity reactions D. Ototoxicity Answer: D. Ototoxicity
  2. Which population should avoid sulphonamides due to the risk of kernicterus? A. Elderly B. Diabetic patients C. Pregnant women near term and neonates D. Hypertensive patients Answer: C. Pregnant women near term and neonates
  3. Sulphasalazine is mainly used for the treatment of: A. Urinary tract infections B. Malaria C. Inflammatory bowel disease D. Pneumocystis pneumonia Answer: C. Inflammatory bowel disease
  4. Resistance to sulphonamides in bacteria is most commonly due to:
  1. The triple combination of pyrimethamine, sulfadoxine, and artesunate is primarily used for: A. Urinary tract infection B. Malaria C. Toxoplasmosis D. Leprosy Answer: B. Malaria
  2. Which laboratory test is important to monitor in patients on prolonged sulphonamide therapy? A. Liver function test B. Serum amylase C. Complete blood count D. Thyroid profile Answer: C. Complete blood count
  3. Sulphonamides can potentiate the effects of which of the following drugs due to plasma protein binding displacement? A. Digoxin B. Warfarin C. Atenolol D. Metformin Answer: B. Warfarin
  4. A patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency is at increased risk of which adverse effect when taking sulphonamides? A. Stevens-Johnson syndrome B. Aplastic anemia

C. Hemolytic anemia D. Renal failure Answer: C. Hemolytic anemia