Pharmacy Hematinic Inorganic Chemistry Unit -4 PPT, Slides of Pharmacy

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Haematin

ics



These are substances required

in the formation of blood & are

used for treatment of anaemias.



Improving the condition of

the blood.



Also called haematinic & agent

that stimulates the production

of red blood cells or increase

the amount of haemoglobin in



Adult male : 0.5-1 mg.



Adult female : 1-2 mg.



Infants : 60 /kg.



Children : 25 /kg.

 Pregnancy (last 2 trimesters) : 3-

mg.

Ferrous sulfate

0 Iron(II) sulfate or iron(II) sulphate ) or ferrous sulfate denotes a range of salts with the formula FeSO 4 · x H 2 O. 0 These compounds exist most commonly as the heptahydrate ( x = 7) but are known for several values of x. 0 FeSO4.H2O (Mineral, relatively rare) 0 FeSO4.4H2O (Mineral, relatively common, white) 0 FeSO4.5H2O (Mineral, relatively rare) 0 FeSO4.6H2O (Mineral, relatively rare) 0 FeSO4.7H2O (Mineral, relatively common, blue-green)

Occurrence

0 All mentioned mineral forms are connected with oxidation zones of iron-bearing ore beds (pyrite, marcasite, chalcopyrite, etc.) and related environments (like coal fire sites). Many undergo rapid dehydration and sometimes oxidation.

Molecular formula FeSO4• 7H2O

Molar mass :278.02 g/mol

Synonym :Green vitriol, Iron vitriol, Copperas

PHYSICAL PROPERTIES

Appearance: It occurs in greenish crystals or crystalline

powder

Odor: Odorless

Density: 1.895 g/cm3 (heptahydrate)

Solubility: soluble in water. Salt dissolve in 1-5 times of

its wt of water at 25 C & about less than half of its weight

of boiling water to form solution and Negligible in

alcohol.

Melting Point: 60–64 °C (heptahydrate) decomposes

PH: Acidic

Ferrous sulfate

Chemical

properties

0 On heating, iron(II) sulfate first loses its water of crystallization and the original green crystals are converted into a brown colored anhydrous solid. When further heated, the anhydrous material releases sulfur dioxide and white fumes of sulfur trioxide, leaving a reddish-brown iron(III) oxide. Decomposition of iron(II) sulfate begins at about 680 °C (1,256 °F). 2 FeSO 4 → Fe 2 O 3 + SO 2 + SO 3

Cont….

0 Like all iron(II) salts, iron(II) sulfate is a reducing agent. 0 For example, it reduces nitric acid to nitrogen monoxide and chlorine to chloride: 6 FeSO 4 + 3 H 2 SO 4 + 2 HNO 3 → 3 Fe 2 (SO 4 ) 3 + 4 H 2 O + 2 NO 6 FeSO 4 + 3 Cl 2 → 2 Fe 2 (SO 4 ) 3 + 2 FeCl 3 0 Upon exposure to air, it oxidizes to form a corrosive brown- yellow coating of "basic ferric sulfate", which is an adduct of iron(III) oxide and iron(III) sulfate: 12 FeSO 4 + 3 O 2 → 4 Fe 2 (SO 4 ) 3 + 2 Fe 2 O 3

Assay

Assay based on oxidation-reduction titration methods.

• (^) Weight accurate about 0.5 gm of ferrous sulfate,

dissolved in a mixture of 25 m of dilute sulfuric acid

and 25 ml of

• (^) freshly boiled and cooled water, and titrate with 0.02M

Potassium permanganate.

• (^) Each ml 0.02M Potassium permanganate is equivalent

to 27.802 mg of FeSO4•7H2O (ferrous sulfate

heptahydrate)

• (^) Each ml 0.02M Potassium permanganate is equivalent

to 27.802 mg of FeSO4 (Anhydrous ferrous sulfate)

Cont…

0 Green vitriol is also a useful reagent in the identification of mushrooms 0 It has been used in the purification of water by flocculation and for phosphate removal in municipal and industrial sewage treatment plants to prevent eutrophication of surface water bodies. 0 Ferrous sulfate can also be used to stain concrete and some limestones and sandstones a yellowish rust color

FERROUS

GLUCONATE

Fine yellowish-grey or pale greenish-yellow powder or granules having a Slight caramel odor Taste : Caramel test

Melting point : 188

0

C

Solubility : Freely but slowly soluble in water giving a

greenish-brown solution, more readily soluble in hot

water, practically insoluble in alcohol, but soluble in

glycerin.

 (^) Molecular formula C 12 H 22 FeO 14 • x H 2 O  (^) Molar mass FeSO 4 •7H 2 O^ 446. (anhydrous)  Synonym (^) Ferrosigluconas

Gluconic acid is first prepared by oxidation of glucose by dilute nitric acid, Preparation:

and then barium carbonate is added to get barium gluconate. This is treated with ferrous sulfate which gives ferrous gluconate Uses

• (^) Ferrous gluconate is effectively used in the treatment of hypochromic anemia.
• (^) Ferrous gluconate is also used as a food additive when processing black olives

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