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Pheochromocytoma: Characteristics and Diagnosis, Study notes of Pathology

Banaras Hindu UniversityPathology

Information on pheochromocytoma, a tumor that arises from chromaffin cells in the adrenal medulla. It discusses the age group affected, the tumor's benign nature, and its unilateral etiology. The document also explains the Rule of 10, which highlights the different types of pheochromocytoma. It describes the morphology of the tumor, including its circumscribed and well-demarcated appearance, and the positive chromaffin reaction. The document also mentions the definitive diagnosis of pheochromocytoma when metastasis is present.

Typology: Study notes

2022/2023

Available from 12/29/2023

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*
PHEOCHROMOCYTOMA
:
↳
is
catcholamine
secreting
tumor
arises
from
chromaffin
cells
in
adrenal
medulla
↳
L
Age
:
3-5
decade
.
Benign
,
unilateral
atiology
:
VH
gen
S
pheochromocytoma
Rule
of
10
:
↳
10
%
are
extra-adrenal
(paragangliomas)
↳
10
%
sporadic
are
bilateral
↳
10
%
are
malignant
a
metastasize
10
%
are
not
/W
HiN
*
Morphology
:
circumscribed
Usion
well
demarcated
,
lobular
pattern
↳
cut
surface
:
yellow
tan
area
of
hemorrhage
&
necrosis
chromaflin
reaction
positive
-
↳
Tumo r
ussue
+
KCR20 -
↓
dark
brown
colour
Cytoplasm
:
fine
granular
↳
Silver
stain
nuclei
:
salt
a
pepper
appearance
IHC
:
Comogamin
a
definitive
diagnosis
:
When
metastasis
Ent
pf2

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* PHEOCHROMOCYTOMA^ :

is (^) catcholamine (^) secreting tumor (^) arises (^) from chromaffin cells (^) in adrenal medulla L Age^ : (^) 3-5 decade. Benign ,^ unilateral atiology :

VH gen S^ pheochromocytoma

Rule (^) of 10 : 10 % (^) are extra-adrenal (^) (paragangliomas)

10 %^ sporadic are bilateral

10 % (^) are (^) malignant a metastasize 10 %^ are not^ /W HiN

  • (^) Morphology :^ circumscribed (^) Usion

well demarcated , lobular pattern

cut (^) surface : yellow tan area (^) of hemorrhage & necrosis chromaflin reaction^ positive Tumor - ussue + KCR20-

dark brown colour

Cytoplasm :^ fine^ granular Silver (^) stain nuclei :^ salt a (^) pepper (^) appearance IHC

:Comogamin

a

definitive diagnosis :^ When^ metastasis^ Ent